HIP1--ALK

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

HIP1 ALK

COSMIC

The fusion gene pair HIP1--ALK information is available in COSMIC database.

Link
HIP1--ALK

ChimerKB

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The fusion gene pair HIP1--ALK information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
HIP1_ALK-/2917/ -/4080/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
HIP1_ALK-/3088/ -/4080/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
HIP1_ALK-/2185+79/ -/4080-1017/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
HIP1_ALK-/-/ -/-/ - hg19 lung adenocarcinoma - 24518094 Oncogene; Cosmic_nonrecurrent
HIP1_ALK-/-/ -/-/ - hg19 non small cell lung cancer - 24496003 Oncogene; Cosmic_nonrecurrent
HIP1_ALK-/-/ -/-/ - hg19 non small cell lung cancer - 25393796 Oncogene; Cosmic_nonrecurrent

ChimerPUB

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The fusion gene pair HIP1--ALK information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
HIP1_ALKt(2;7) / p23;q11.23 / 24518094non small cell lung cancer;adenocarcinoma FISH - The novel fusion gene and its protein HIP1-ALK harboring epsin N-terminal homology, coiled-coil, juxtamembrane, and kinase domains, which could play a role in carcinogenesis, could become diagnostic and therapeutic target of the lung adenocarcinoma and deserve a further study in the future.. /// "The novel fusion gene and its protein HIP1-ALK harboring epsin N-terminal homology, coiled-coil, juxtamembrane, and kinase domains, which could play a role in carcinogenesis, could become diagnostic and therapeutic target of the lung adenocarcinoma and deserve a further study in the future.." /// "HIP1-ALK, a novel fusion protein identified in lung adenocarcinoma.. "
HIP1_ALKt(2;7) / p23;q11.23 / 24518094non small cell lung cancer;adenocarcinoma FISH - In this article, we report a novel fusion gene huntingtin interacting protein 1 (HIP1)-ALK, which is conjoined between the huntingtin-interacting protein 1 gene HIP1 and ALK.
HIP1_ALK- 25393796non small cell lung cancer;lung cancer - - However, the response of patients with NSCLC harboring HIP1-ALK to ALK inhibitors and potential resistance mechanisms to such remain unknown. /// "To date, two variants of HIP1-ALK (H21. " /// Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib.. /// "Here, we report a patient with NSCLC harboring a novel HIP1-ALK fusion variant (H30. " /// "Here, we report a patient with NSCLC harboring a novel HIP1-ALK fusion variant (H30; A20)."
HIP1_ALK- 24496003non small cell lung cancer;squamous cell carcinoma;non small cell lung cancer;small cell lung cancer - - Two ALK-rearranged NSCLC PDX models were identified: one carried a well-known EML4-ALK variant 3a/b and the other harbored a novel huntingtin interacting protein 1 (HIP1)-ALK fusion gene.
HIP1_ALK- 25567908adenocarcinoma - - Actionable genomic alterations with a targeted agent based on NCCN guidelines were identified in 26% [8 of 31: EGFR G719A, BRAF V600E, SOCS5-ALK, HIP1-ALK, CD74-ROS1, KIF5B-RET (n = 2), CCDC6-RET].
HIP1_ALK- 24496003non small cell lung cancer;squamous cell carcinoma;non small cell lung cancer;small cell lung cancer - - HIP1-ALK, a novel ALK fusion variant that responds to crizotinib.. /// "HIP1-ALK, a novel ALK fusion variant that responds to crizotinib."

ChimerSEQ

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The fusion gene pair HIP1--ALK information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair HIP1--ALK information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair HIP1--ALK information is not available in FARE-CAFE.

TicDB

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The fusion gene pair HIP1--ALK information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair HIP1--ALK information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair HIP1--ALK information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair HIP1--ALK information is not available in ConjoinG Database.

1000Genome

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Fusion gene HIP1--ALK has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene HIP1--ALK is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene HIP1--ALK is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene HIP1--ALK is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene HIP1--ALK was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair HIP1--ALK information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene HIP1--ALK is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene HIP1--ALK has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene HIP1 is not a known oncogene according to ONGENE database.


The tail gene ALK is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene HIP1 is cancer associated according to Bushman Cancer Gene database.


The tail gene ALK is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene HIP1 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene ALK is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene HIP1--ALK is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene HIP1--ALK is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair HIP1--ALK information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene HIP1--ALK is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene HIP1--ALK has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair HIP1--ALK information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair HIP1--ALK information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair HIP1--ALK information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene HIP1--ALK is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair HIP1--ALK information is not available in ChromothripsisDB database.