GOPC--ROS1

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

GOPC ROS1

COSMIC

The fusion gene pair GOPC--ROS1 information is available in COSMIC database.

Link
GOPC--ROS1

ChimerKB

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The fusion gene pair GOPC--ROS1 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
GOPC_ROS1-/1334/ -/5841/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
GOPC_ROS1-/1334+2304/ -/5841-2355/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
GOPC_ROS1-/726/ -/5977/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
GOPC_ROS1-/1334+2402/ -/5841-621/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
GOPC_ROS1-/726+822/ -/5977-563/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
GOPC_ROS1-/-/ -/-/ - hg19 glioma - 12661006 Oncogene; Cosmic_nonrecurrent
GOPC_ROS1-/-/ -/-/ - hg19 cholangiocarcinoma - 21253578 Oncogene; Cosmic_nonrecurrent
GOPC_ROS1-/-/ -/-/ - hg19 low malignant potential tumour - 22163003 Oncogene; Cosmic_nonrecurrent
GOPC_ROS1-/-/ -/-/ - hg19 non small cell lung cancer - 22661537 Oncogene; Cosmic_nonrecurrent
GOPC_ROS1-/-/ -/-/ - hg18 astrocytoma - - Oncogene; Mitelman
GOPC_ROS1-/2304/ -/583/ Exonic hg18 - - - Oncogene; TICdb

ChimerPUB

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The fusion gene pair GOPC--ROS1 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
GOPC_ROS1- 23052255lung cancer;adenocarcinoma FISH;PCR;RT-PCR - RACE isolated a GOPC-ROS1 (FIG-ROS1) fusion in the former and a KIF5B-RET fusion in the latter, both confirmed by RT-PCR. /// We also report in lung cancer the GOPC-ROS1 fusion originally discovered and characterized in a glioma cell line.. /// "RACE isolated a GOPC-ROS1 (FIG-ROS1) fusion in the former and a KIF5B-RET fusion in the latter, both confirmed by RT-PCR. " /// Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions..
GOPC_ROS1- 24999209- - - Lack of GOPC-ROS1 (FIG-ROS1) rearrangement in adult human gliomas. /// Lack of GOPC-ROS1 (FIG-ROS1) rearrangement in adult human gliomas..

ChimerSEQ

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The fusion gene pair GOPC--ROS1 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair GOPC--ROS1 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair GOPC--ROS1 information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
GOPC-ROS1 Glioblastoma _ (6)(q21q21) PubMed:12661006

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
GOPC-ROS1 GOPC-ROS1 GOPC _ _ 0 ROS1 _ 0 _ TTTATAGATATATATATcGTAGATAGAAAGCTATTT 12661006 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
GOPC-ROS1 GOPC-ROS1 - - - -GOPC 1) PDZ
1) EBP50_C-term , PID , SAM_1 , fn3 , Metallophos , Porin_1 , SH3_2 , PDZ , RIIa , Trypsin , PDZ_2 , Ras , Trypsin_2 , DUF4136 , V-set
ROS1 1) fn3
2) Pkinase_Tyr
1) RGM_N , SH2 , CH , HH_signal , IL12p40_C , IL6Ra-bind , Lipocalin , EPO_TPO , Hormone_1 , IL2 , IL7 , PDZ , Rad60-SLD , V-set , EpoR_lig-bind , Hormone_recep , IL4 , Ig_2 , Pkinase , Recep_L_domain , fn3 , Glyco_hydro_28 , I-set , IL6 , Lectin_C , RGM_C , SBP_bac_1
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) PDZ
2) fn3
3) Pkinase_Tyr
1) EBP50_C-term , PID , SAM_1 , fn3 , Metallophos , Porin_1 , SH3_2 , PDZ , RIIa , Trypsin , PDZ_2 , Ras , Trypsin_2 , DUF4136 , V-set
2) RGM_N , SH2 , CH , HH_signal , IL12p40_C , IL6Ra-bind , Lipocalin , EPO_TPO , Hormone_1 , IL2 , IL7 , PDZ , Rad60-SLD , V-set , EpoR_lig-bind , Hormone_recep , IL4 , Ig_2 , Pkinase , Recep_L_domain , fn3 , Glyco_hydro_28 , I-set , IL6 , Lectin_C , RGM_C , SBP_bac_1
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
GOPC-ROS1 hsa-miR-26b-5p hsa-miR-130b-3phsa-miR-103a-3p Microarray

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
GOPC-ROS1 NM_001017408.2 1) STAT1_HUMAN
2) RB1_HUMAN
3) RBL2_HUMAN
4) ETS1_HUMAN
5) FOS_HUMAN
6) GATA3_HUMAN
7) E2F1_HUMAN
8) CTCF_HUMAN
9) BRG1_HUMAN
10) HNF4A_HUMAN
11) TFAP2C_HUMAN
12) FOXA1_HUMAN
13) CEBPA_HUMAN
14) TRIM24_HUMAN
15) VDR_HUMAN
1) EGR1_HUMAN
2) AR_HUMAN
1) 19122651
2) 20385362
3) 20385362
4) 20019798
5) 20139302
6) 21878914
7) 21310950
8) 21795385
9) 19505939
10) 21646355
11) 21572391
12) 21572391
13) 20219941
14) 21164480
15) 21846776

TicDB

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The fusion gene pair GOPC--ROS1 information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
GOPC ROS1 12661006 TTTATAGATATATATATcGTAGATAGAAAGCTATTT

TUMOR FUSION Gene Data Portal

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The fusion gene pair GOPC--ROS1 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair GOPC--ROS1 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair GOPC--ROS1 information is available in ConjoinG Database.
ConjoinG_IDChromosomemRNA_EST_AccessionsParent_Genes
CGHSA0278 6X51619 GOPC ROS1

1000Genome

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Fusion gene GOPC--ROS1 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene GOPC--ROS1 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene GOPC--ROS1 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene GOPC--ROS1 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene GOPC--ROS1 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair GOPC--ROS1 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene GOPC--ROS1 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene GOPC--ROS1 has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene GOPC is a known oncogene according to ONGENE database.


The tail gene ROS1 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene GOPC is cancer associated according to Bushman Cancer Gene database.


The tail gene ROS1 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene GOPC is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene ROS1 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene GOPC--ROS1 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene GOPC--ROS1 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair GOPC--ROS1 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene GOPC--ROS1 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene GOPC--ROS1 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair GOPC--ROS1 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair GOPC--ROS1 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair GOPC--ROS1 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene GOPC--ROS1 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair GOPC--ROS1 information is not available in ChromothripsisDB database.