FLI1--EWSR1

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

FLI1 EWSR1

COSMIC

The fusion gene pair FLI1--EWSR1 information is not available in COSMIC database.

ChimerKB

Top
The fusion gene pair FLI1--EWSR1 information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

Top
The fusion gene pair FLI1--EWSR1 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
FLI1_EWSR1t(11;22) / 16944972ewing sarcoma;neuroectodermal tumor;neuroblastoma;sarcoma FISH - Interphase and metaphase fluorescent in situ hybridization (FISH) studies performed on the pretreatment and posttreatment samples showed the presence of a t(11;22) rearrangement resulting in EWSR1/FLI1 gene fusion consistent with pPNET/EWS in both specimens.
FLI1_EWSR1t(11;22)(q24;q12) / 20513536ewing sarcoma;sarcoma FISH;PCR;RT-PCR - Reverse-transcriptase polymerase chain reaction (RT-PCR) analysis, however, identified EWSR1-FLI1 fusion transcripts in both tumors, and the gene fusions were corroborated by FISH analysis with "in house" probes and confirmed by sequencing RT-PCR products. /// Cryptic EWSR1-FLI1 fusions in Ewing sarcoma: potential pitfalls in the diagnostic use of fluorescence in situ hybridization probes.. /// "The occurrence of cryptic EWSR1-FLI1 fusions mandates that RT-PCR should be performed, particularly in those cases in which the genetic findings are not in agreement with the histologic picture.. "
FLI1_EWSR1t(11;22) / t(2;13) / 19214114synovial sarcoma;rhabdomyosarcoma;neuroblastoma;sarcoma FISH - Karyotype on fresh tissue represents a genome-wide screen of gross chromosomal alterations, whereas fluorescence in situ hybridization and polymerase chain reaction detect specific defects that are characteristic of a given tumor type such as t(11;22) EWSR1-FLI1 in Ewing family tumors, t(X;18) SS18-SSX1 in synovial sarcoma, t(2;13) PAX3-FOXO1A in alveolar rhabdomyosarcoma, and MYCN gene amplification in neuroblastoma.
FLI1_EWSR1t(4;22)(q31;q12) / 21113140ewing sarcoma;neuroectodermal tumor;sarcoma FISH;PCR;RT-PCR - Over 90% of Ewing sarcoma/primitive neuroectodermal tumors (PNETs) feature an 11;22 translocation leading to an EWSR1-FLI1 fusion.
FLI1_EWSR1t(11;22) / t(21;22) / 23706910ewing sarcoma;sarcoma FISH;PCR;RT-PCR - RT-PCR was positive in 27 (84.4%) of 32 patients, including 24 EWSR1-FLI1 and 3 EWSR1-ERG.
FLI1_EWSR1- 24675777chronic myeloid leukemia;myeloid leukemia;leukemia;ewing sarcoma;sarcoma;lymphoma FISH - We demonstrate this method by detecting the BCR-ABL fusion transcripts that occur in chronic myeloid leukemia cells, and by detecting the EWSR1-FLI1 fusion transcripts that occur in Ewing's sarcoma cells.
FLI1_EWSR1- 18615675ewing tumor; nephroblastoma FISH - This approach revealed several submicroscopic chromosomal aberrations and three different seemingly balanced translocations, resulting in a heterozygous deletion of HACE1, an EWSR1/ERG fusion, and an EWSR1/FLI1 fusion, respectively.
FLI1_EWSR1- 12522555ewing sarcoma;sarcoma FISH - Comparing results obtained for the EWSR1/FLI1 and ABL1/BCR genes in samples of patients suffering from Ewing sarcoma or chronic myelogenous leukaemia, it can be concluded that the mean positions of the fusion genes are determined by the final structure of the chimeric chromosomes and do not depend on the location of the translocation event..
FLI1_EWSR1- 26675070clear cell sarcoma;ewing sarcoma;sarcoma FISH - However, polymerase chain reaction testing for ES-specific rearrangements (EWSR1/FLI1, EWSR1/ERG, EWSR1/ETV1, EWSR1/ETV4, EWS/FEV) failed to confirm the ES origin of the neoplastic tissue.
FLI1_EWSR1- 24498265ewing sarcoma PCR;RT-PCR - We determined that MSC-P lack the most prevalent gene fusion, EWSR1-FLI1 as well as EWSR1 gene rearrangements.
FLI1_EWSR1t(11;22) (q24;q12) / 25948942ewing sarcoma;sarcoma - - We report a case of primary renal ES in a young male, which had a t(11;22) (q24;q12) chromosome translocation encoding a type2 EWSR1/FLI1 fusion transcript. /// "Upregulation of NKX2.2, a target of EWSR1/FLI1 fusion transcript, in primary renal Ewing sarcoma.. " /// "The tumor cells showed diffuse cytoplasmic immunoreactivity for CD99 and diffuse nuclear immunoreactivity for NKX2.2, an important oncogenic transcriptional target of EWSR1/FLI1, not only in the histological, but also in the cytological specimens. "
FLI1_EWSR1- 10508522ewing sarcoma;sarcoma - - Introduction of EWSR1-FLI1 into cells lacking the EWSR1-FLI1 fusion suppresses TGF-beta RII expression, whereas antisense to EWSR1-FLI1 in ES cell lines positive for this gene fusion restores TGF-beta RII expression. /// "It has been shown that transduction of the gene EWSR1-FLI1 (encoding EWS-FLI1 protein) can transform NIH3T3 cells, and that mutants containing a deletion in either the EWS domain or the DNA-binding domain in FLI1 lose this ability. " /// "Co-transfection of FLI1 and the TGFBR2 promoter induces promoter activity, whereas EWSR1-FLI1 leads to suppression of TGFBR2 promoter activity and FLI1-induced promoter activity. " /// "We show here that Ewing sarcoma [corrected] (ES) cell lines with the EWSR1-FLI1 fusion have reduced TGF-beta sensitivity, and that fusion-positive ES cells and primary tumours both express low or undetectable levels of TGFBR2 mRNA and protein product. "
FLI1_EWSR1- 24898918ewing sarcoma;sarcoma FISH;PCR;RT-PCR - Tumours were investigated by means of immunohistochemistry, RT-PCR (EWSR1-FLI1, EWSR1-ERG and EWSR1-FEV transcripts), FISH analysis (EWSR1 break-apart and specific EWSR1-FEV translocation) and spectral karyotyping (SKY). /// "FISH identified EWSR1 rearrangement in all cases, with EWSR1-FLI1 transcripts being detected in all but one tumour showing the uncommon EWSR1-FEV rearrangement, with SKY, RT-PCR and FISH confirmation. " /// "Most primary Ewing sarcomas of the ileum show the common EWSR1-FLI1 translocation, but EWSR1-FEV could be specific for tumours arising in the ileum and showing better prognosis.. " /// "The mean survival of EWSR1-FLI1 patients was 14?months, whereas the EWSR1-FEV patient was alive after 15?years despite several recurrences controlled by surgery alone. "
FLI1_EWSR1t(11;22)(q24;q12) / t(2;5)(p23;q35) / 23568838anaplastic large cell lymphoma;ewing sarcoma;sarcoma;lymphoma - - We recovered both translocations with high efficiency, resulting in the expression of the EWSR1-FLI1 and NPM1-ALK fusions.
FLI1_EWSR1- 25591392cardiac failure;dilated cardiomyopathy - - As a result Ewsr1-Fli1 fusion transcripts were expressed, suggesting a functional Ews-Fli1 protein might be synthesized in vivo.
FLI1_EWSR1- 24735198ewing sarcoma;sarcoma PCR;RT-PCR - However, reverse transcription-polymerase chain reaction (RT-PCR) analysis confirmed the presence of a rare variant of the EWSR1-FLI1 fusion transcript, featuring fusion of EWSR1 exon 10 to FLI1 exon 6. /// Primary subcutaneous spindle cell Ewing sarcoma with strong S100 expression and EWSR1-FLI1 fusion: a case report.. /// "Ewing sarcoma most often is characterized by a fusion of the Ewing sarcoma breakpoint region 1 (EWSR1) and the Friend leukemia virus integration 1 (FLI1) genes, forming an EWSR1-FLI1 fusion transcript. "
FLI1_EWSR1- 23015660ewing sarcoma;sarcoma PCR;RT-PCR - Our aim was to establish a sensitive method which is able to identify all combinatorially possible EWSR1-FLI1 and EWSR1-ERG translocation transcripts in FFPE tissue samples despite significant RNA-degradation. /// "Using this method, we processed 60 FFPE samples of Ewing sarcoma family of tumours, and identified six types EWSR1-FLI1 and one type EWSR1-ERG chimeric transcripts acceptable for RT-PCR analysis in 27 out of 45 samples. " /// "The combination of fluorescent multiplex PCR with laser-induced capillary electrophoresis was used to detect and identify EWSR1-FLI1 and EWSR1-ERG chimeric transcripts on the basis of amplicon size, and forward primers labelled by distinct fluorophores. "
FLI1_EWSR1- 23185447rhabdomyosarcoma;ewing sarcoma;sarcoma - - We crossed a publicly available list of all putative EWSR1-FLI1 target genes in ESFT with our microarray expression data on 24 PCa and 6 non-malignant prostate tissues (NPT) and choose four genes among the top-most differentially expressed between PCa with (PCa ERG+) and without (PCa ETS-) ETS fusion genes (HIST1H4L, KCNN2, ECRG4 and LDOC1), as well as four well-validated direct targets of the EWSR1-FLI1 chimeric protein in ESFT (NR0B1, CAV1, IGFBP3 and TGFBR2). /// "Using quantitative expression analysis in 16 ESFT and seven alveolar rhabdomyosarcomas (ARMS), we were able to validate the four genes previously described as direct targets of the EWSR1-FLI1 oncoprotein, showing overexpression of CAV1 and NR0B1 and underexpression of IGFBP3 and TGFBR2 in ESFT as compared to ARMS. "
FLI1_EWSR1- 24993903bone cancer - - Ewing sarcoma is molecularly defined by a fusion of the EWSR1 gene (or rarely the related FUS gene) to a member of the E26 transformation-specific (ETS) family of transcription factors, frequently the EWSR1-FLI1 fusion.
FLI1_EWSR1- 26847175myoepithelioma - - NKX2-2, a homeodomain transcription factor involved in neuroendocrine/glial differentiation and a downstream target of EWSR1-FLI1, has been reported as an immunohistochemical marker for Ewing sarcoma. /// "NKX2-2 was positive in 37/40 (93%) Ewing sarcomas, including all atypical Ewing sarcomas and cases with known EWSR1-FLI1 or EWSR1-ERG fusion. "
FLI1_EWSR1- 23940108ewing sarcoma;prostate cancer;sarcoma - - We performed an integrative study of genome-wide DNA-binding and transcription data in EWSR1/FLI1 expressing ES and TMPRSS2/ERG containing PC cells. /// "Thus, EWSR1/FLI1 appears to promote oncogenesis by simultaneously promoting cell proliferation and perturbing differentiation. " /// "While synergistic regulation in concert with E2F in the promoter of target genes has a generally activating effect, EWSR1/FLI1 binding independent of E2F3 is predominantly associated with repressed differentiation genes. " /// "Additionally, a detailed analysis of the regulatory targets of the characteristic EWSR1/FLI1 fusion in ES identifies two functionally distinct gene sets. "
FLI1_EWSR1- 26765686ewing sarcoma;sarcoma - - IGF-1R: The IGF-1R pathway is known to be deregulated by the EWSR1-FLI1 translocation which makes it a potential target for therapy.
FLI1_EWSR1- 22460902ewing sarcoma;sarcoma - - Unexpected relationships were revealed, including the marked sensitivity of Ewing's sarcoma cells harbouring the EWS (also known as EWSR1)-FLI1 gene translocation to poly(ADP-ribose) polymerase (PARP) inhibitors.
FLI1_EWSR1- 26056084ewing sarcoma;sarcoma - - Trabectedin is an antitumoral agent that modulates EWSR1-FLI1 transcriptional functions, causing DNA damage. /// "Interestingly, PARP1 is also a transcriptional regulator of EWSR1-FLI1, and PARPinh disrupts the DDR machinery. " /// "The drug combination also enhanced ?H2AX intranuclear accumulation as a result of DNA damage induction, DNA fragmentation and global DDR deregulation, while EWSR1-FLI1 target expression remained unaffected." /// "Thus, given the impact and apparent specificity of both agents with regard to the DNA damage/DDR system and EWSR1-FLI1 activity in ES, we decided to explore the activity of combining PARPinh and Trabectedin in in vitro and in vivo experiments. " /// "The drug combination also enhanced ?H2AX intranuclear accumulation as a result of DNA damage induction, DNA fragmentation and global DDR deregulation, while EWSR1-FLI1 target expression remained unaffected. "
FLI1_EWSR1t(14;22)(q32;q12) / 23630070mesothelioma - - The EWSR1 breakpoint in exon 8 in the EWSR1-YY1 chimeric transcript is similar to what is found in other fusions involving EWSR1 such as EWSR1-FLI1, EWSR1-DDIT3, and EWSR1-ATF1. /// "The EWSR1 breakpoint in exon 8 in the EWSR1-YY1 chimeric transcript is similar to what is found in other fusions involving EWSR1 such as EWSR1-FLI1, EWSR1-DDIT3, and EWSR1-ATF1."
FLI1_EWSR1- 11823984ewing sarcoma;sarcoma - - This type of tumor is well characterized by recurrent chromosomal translocation such as t (11;22) (q24;q12) (EWSR1/FLI1) or t (21;22) (q22;q12) (EWSR1/ERG) and overexpression of MIC2/CD99 on tumor cell membrane.
FLI1_EWSR1t(11;22) / t(21;22) / t(2;22) / 21458383- - - We found five distinct types of EWSR1-FLI1 fusion transcripts resulting from translocation t(11;22), three types of EWSR1-ERG transcripts resulting from t(21;22), and one type of t(2;22) resulting in EWSR1-FEV fusion.
FLI1_EWSR1t(11;22) / t(21;22) / 22703924ewing sarcoma;neuroectodermal tumor;neuroblastoma;sarcoma ISH - Fluorescence in situ hybridization analysis revealed the presence of EWSR1/FLI1 translocation in both histologic distinct components. /// Extraosseous Ewing sarcoma with foci of neuroblastoma-like differentiation associated with EWSR1(Ewing sarcoma breakpoint region 1)/FLI1 translocation without prior chemotherapy..

ChimerSEQ

Top
The fusion gene pair FLI1--EWSR1 information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
FLI1_EWSR1chr11/128667504/ chr22/29684300/ 11q24.3 22q12.2 Exonic hg19 - Inter-chr NA JX266518 - ChiTaRs
FLI1_EWSR1chr11/128660607/ chr22/29684449/ 11q24.3 22q12.2 Exonic hg19 - Inter-chr NA JX266523 - ChiTaRs
FLI1_EWSR1chr11/128667041/ chr22/29684818/ 11q24.3 22q12.2 Exonic hg19 - Inter-chr NA JX266510 - ChiTaRs
FLI1_EWSR1chr11/128652200/ chr22/29685275/ 11q24.3 22q12.2 Exonic hg19 - Inter-chr NA JX266528 - ChiTaRs
FLI1_EWSR1chr11/128650068/ chr22/29683677/ 11q24.3 22q12.2 Exonic hg19 - Inter-chr NA JX266512 - ChiTaRs
FLI1_EWSR1chr11/128678882/ chr22/29684048/ 11q24.3 22q12.2 Exonic hg19 - Inter-chr NA JX266514 - ChiTaRs
FLI1_EWSR1chr11/128675063/ chr22/29683875/ 11q24.3 22q12.2 Exonic hg19 - Inter-chr NA JX266516 - ChiTaRs
FLI1_EWSR1chr11/128659606/ chr22/29683933/ 11q24.3 22q12.2 Exonic hg19 - Inter-chr NA AJ229260 - ChiTaRs
FLI1_EWSR1chr11/128653521/ chr22/29683664/ 11q24.3 22q12.2 Exonic hg19 - Inter-chr NA AJ229265 - ChiTaRs
FLI1_EWSR1chr11/128647310/ chr22/29684764/ 11q24.3 22q12.2 Exonic hg19 - Inter-chr NA AJ229263 - ChiTaRs
FLI1_EWSR1chr11/128646994/ chr22/29684685/ 11q24.3 22q12.2 Exonic hg19 - Inter-chr NA AJ229256 - ChiTaRs

ChiTaRS 2.1

Top
The fusion gene pair FLI1--EWSR1 information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human JX266518FLI1--EWSR1 FLI111 128667441 128667504 + 1 64 98.5 EWSR122 29684300 29684460 + 65 225 99.4
Human JX266523FLI1--EWSR1 FLI111 128660468 128660607 + 1 140 100 EWSR122 29684449 29684536 + 139 225 100
Human JX266510FLI1--EWSR1 FLI111 128666894 128667041 + 1 148 99.4 EWSR122 29684818 29684894 + 149 225 100
Human JX266528FLI1--EWSR1 FLI111 128652054 128652200 + 1 147 100 EWSR122 29685275 29685353 + 147 225 100
Human JX266512FLI1--EWSR1 FLI111 128649944 128650068 + 1 119 99.2 EWSR122 29683677 29683782 + 120 225 100
Human JX266514FLI1--EWSR1 FLI111 128678738 128678882 + 1 145 100 EWSR122 29684048 29684130 + 143 225 100
Human JX266516FLI1--EWSR1 FLI111 128674984 128675063 + 1 80 100 EWSR122 29683875 29684021 + 79 225 100
Human AJ229260FLI1--EWSR1 FLI111 128659497 128659606 + 1 102 99 EWSR122 29683933 29684020 + 93 180 100
Human AJ229265FLI1--EWSR1 FLI111 128653438 128653521 + 1 84 100 EWSR122 29683664 29683759 + 85 180 100
Human AJ229263FLI1--EWSR1 FLI111 128647199 128647310 + 1 112 100 EWSR122 29684764 29684832 + 112 180 100
Human AJ229256FLI1--EWSR1 FLI111 128646899 128646994 + 1 96 100 EWSR122 29684685 29684768 + 97 180 100

FARE-CAFE

Top
The fusion gene pair FLI1--EWSR1 information is not available in FARE-CAFE.

TicDB

Top
The fusion gene pair FLI1--EWSR1 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

Top
The fusion gene pair FLI1--EWSR1 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

Top
The fusion gene pair FLI1--EWSR1 information is not available in FusionCancer Database.

ConjoinG

Top
The fusion gene pair FLI1--EWSR1 information is not available in ConjoinG Database.

1000Genome

Top
Fusion gene FLI1--EWSR1 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

Top
Fusion gene FLI1--EWSR1 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

Top
Fusion gene FLI1--EWSR1 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

Top
Fusion gene FLI1--EWSR1 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

Top
Fusion gene FLI1--EWSR1 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

Top
The fusion gene pair FLI1--EWSR1 information is not available in Babiceanu_Dataset.

Banned_Dataset

Top
Fusion gene FLI1--EWSR1 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

Top
Fusion gene FLI1--EWSR1 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

Top
The head gene FLI1 is a known oncogene according to ONGENE database.


The tail gene EWSR1 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

Top
The head gene FLI1 is cancer associated according to Bushman Cancer Gene database.


The tail gene EWSR1 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

Top
The head gene FLI1 is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene EWSR1 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

Top
Fusion gene FLI1--EWSR1 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

Top
Fusion gene FLI1--EWSR1 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

Top
The fusion gene pair FLI1--EWSR1 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

Top
Fusion gene FLI1--EWSR1 is not found in pancreatic tumor dataset, published here.

GTEx

Top
Fusion gene FLI1--EWSR1 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

Top
The fusion gene pair FLI1--EWSR1 information is available in Klijn Dataset.

Cell lineGene 5'Gene 3'Read evidenceKinaseChromosome 5'Position 5'Chromosome 3'Position 3'Fusion type DNAFusion type RNAFusion protein lengthTissueKnown Fusion
A-673FLI1EWSR19N111286519182229688126TranslocinFrame537Sarcomatoid3-prime known

Fimereli_Dataset

Top
The fusion gene pair FLI1--EWSR1 information is not found in Fimereli_Dataset.

Literature

Top
The fusion gene pair FLI1--EWSR1 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

Top
Fusion gene FLI1--EWSR1 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

Top
The fusion gene pair FLI1--EWSR1 information is not available in ChromothripsisDB database.