FGFR3--TACC3

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

FGFR3 TACC3

COSMIC

The fusion gene pair FGFR3--TACC3 information is available in COSMIC database.

Link
FGFR3--TACC3

ChimerKB

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The fusion gene pair FGFR3--TACC3 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
FGFR3_TACC3-/2530+38/ -/2048-1459/ Exonic hg19 - - - Kinase; Cosmic_recurrent
FGFR3_TACC3-/2530/ -/1943/ Exonic hg19 - - - Kinase; Cosmic_recurrent
FGFR3_TACC3-/2654/ -/1751-371/ Exonic hg19 - - - Kinase; Cosmic_recurrent
FGFR3_TACC3-/2530+136/ -/2048-1830/ Exonic hg19 - - - Kinase; Cosmic_recurrent
FGFR3_TACC3-/2530+63/ -/1877/ Exonic hg19 - - - Kinase; Cosmic_recurrent
FGFR3_TACC3-/2530+104/ -/541/ Exonic hg19 - - - Kinase; Cosmic_recurrent
FGFR3_TACC3-/2530+27/ -/2048-1511/ Exonic hg19 - - - Kinase; Cosmic_recurrent
FGFR3_TACC3-/2530/ -/1751/ Exonic hg19 - - - Kinase; Cosmic_recurrent
FGFR3_TACC3-/-/ -/-/ - hg19 bladder cancer - 23175443 Kinase; Cosmic_nonrecurrent
FGFR3_TACC3-/-/ -/-/ - hg19 glioma - 22837387 Kinase; Cosmic_nonrecurrent
FGFR3_TACC3-/-/ -/-/ - hg19 lung adenocarcinoma - 23661334 Kinase; Cosmic_nonrecurrent
FGFR3_TACC3-/-/ -/-/ - hg19 urothelial carcinoma - 23887298 Kinase; Cosmic_nonrecurrent
FGFR3_TACC3chr4/1808661/ chr4/1741429/ Genomic hg19 head and neck squamous cell carcinoma RT-PCR;Sanger sequencing 26949921 Kinase; Literature_Curation

ChimerPUB

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The fusion gene pair FGFR3--TACC3 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
FGFR3_TACC3- 24452392squamous cell carcinoma;lung cancer PCR;RT-PCR - We also examined 190 LCs for the FGFR3-TACC3 and FGFR3-BAIAP2L1 fusion transcripts using reverse transcription-polymerase chain reaction (RT-PCR) analysis. /// "Although the expression of FGFR3-TACC3 and FGFR3-BAIAP2L1 fusion transcripts was not detected in any of the carcinomas, somatic FGFR3 mutations were detected in two (0.9%) LCs. "
FGFR3_TACC3- 24850843non small cell lung cancer;lung cancer PCR;RT-PCR - Of 1,328 tumors screened, two (0.2%) were BAG4-FGFR1 fusion and 15 (1.1%) were FGFR3-TACC3 fusion. /// "Of 1,328 tumors screened, two (0.2%) were BAG4-FGFR1 fusion and 15 (1.1%) were FGFR3-TACC3 fusion. " /// "Six of 1,016 patients with lung adenocarcinoma were FGFR3-TACC3 fusions and 11 of 312 lung squamous cell carcinoma harbored BAG4-FGFR1 or FGFR3-TACC3 fusions. "
FGFR3_TACC3- 25950492breast cancer - - Of 391 patients, 56 (14.3%) had aberrant FGF (N = 38, all amplifications) and/or FGFR (N = 22 including 5 mutations and one FGFR3-TACC3 fusion).

ChimerSEQ

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The fusion gene pair FGFR3--TACC3 information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
FGFR3_TACC3chr4/1808661/+ chr4/1741428/+ 4p16.3 4p16.3 Exonic hg19 In-Frame Intra-chr LUSC TCGA-39-5024-01A Kinase; FusionScan
FGFR3_TACC3chr4/1808660/+ chr4/1732898/+ 4p16.3 4p16.3 Exonic hg19 In-Frame Intra-chr LGG TCGA-P5-A72U-01A Kinase; TopHat-Fusion
FGFR3_TACC3chr4/1808660/+ chr4/1741428/+ 4p16.3 4p16.3 Exonic hg19 In-Frame Intra-chr LGG TCGA-FG-7643-01A Kinase; TopHat-Fusion
FGFR3_TACC3chr4/1808660/+ chr4/1737457/+ 4p16.3 4p16.3 Exonic hg19 In-Frame Intra-chr CESC TCGA-WL-A834-01A Kinase; TopHat-Fusion
FGFR3_TACC3chr4/1808660/+ chr4/1741428/+ 4p16.3 4p16.3 Exonic hg19 In-Frame Intra-chr BLCA TCGA-E7-A5KE-01A Kinase; TopHat-Fusion
FGFR3_TACC3chr4/1808660/+ chr4/1737457/+ 4p16.3 4p16.3 Exonic hg19 In-Frame Intra-chr BLCA TCGA-CF-A8HY-01A Kinase; TopHat-Fusion
FGFR3_TACC3chr4/1808650/+ chr4/1737483/+ 4p16.3 4p16.3 Exonic hg19 In-Frame Intra-chr LUSC TCGA-39-5024-01A Kinase; TopHat-Fusion
FGFR3_TACC3chr4/1808660/+ chr4/1741428/+ 4p16.3 4p16.3 Exonic hg19 In-Frame Intra-chr LUSC TCGA-39-5024-01A Kinase; TopHat-Fusion
FGFR3_TACC3chr4/1808660/+ chr4/1741428/+ 4p16.3 4p16.3 Exonic hg19 In-Frame Intra-chr LUSC TCGA-66-2786-01A Kinase; TopHat-Fusion
FGFR3_TACC3chr4/1808661/+ chr4/1741429/+ 4p16.3 4p16.3 Exonic hg19 In-frame Intra-chr BLCA TCGA-CF-A3MF-01A Kinase; PRADA
FGFR3_TACC3chr4/1808661/+ chr4/1741429/+ 4p16.3 4p16.3 Exonic hg19 In-frame Intra-chr BLCA TCGA-CF-A3MG-01A Kinase; PRADA
FGFR3_TACC3chr4/1808661/+ chr4/1741429/+ 4p16.3 4p16.3 Exonic hg19 In-frame Intra-chr BLCA TCGA-CF-A3MH-01A Kinase; PRADA
FGFR3_TACC3chr4/1808661/+ chr4/1741429/+ 4p16.3 4p16.3 Exonic hg19 In-frame Intra-chr GBM TCGA-06-2567-01A Kinase; PRADA
FGFR3_TACC3chr4/1808661/+ chr4/1741429/+ 4p16.3 4p16.3 Exonic hg19 In-frame Intra-chr GBM TCGA-14-0789-01A Kinase; PRADA
FGFR3_TACC3chr4/1808661/+ chr4/1741429/+ 4p16.3 4p16.3 Exonic hg19 In-frame Intra-chr GBM TCGA-14-1823-01A Kinase; PRADA
FGFR3_TACC3chr4/1808661/+ chr4/1741429/+ 4p16.3 4p16.3 Exonic hg19 In-frame Intra-chr GBM TCGA-14-1829-01A Kinase; PRADA
FGFR3_TACC3chr4/1808661/+ chr4/1741429/+ 4p16.3 4p16.3 Exonic hg19 In-frame Intra-chr GBM TCGA-27-1835-01A Kinase; PRADA
FGFR3_TACC3chr4/1808661/+ chr4/1739325/+ 4p16.3 4p16.3 Exonic hg19 In-frame Intra-chr GBM TCGA-76-4925-01A Kinase; PRADA
FGFR3_TACC3chr4/1808661/+ chr4/1739325/+ 4p16.3 4p16.3 Exonic hg19 In-frame Intra-chr HNSC TCGA-CR-6473-01A Kinase; PRADA
FGFR3_TACC3chr4/1808661/+ chr4/1741429/+ 4p16.3 4p16.3 Exonic hg19 In-frame Intra-chr HNSC TCGA-CV-7100-01A Kinase; PRADA
FGFR3_TACC3chr4/1808661/+ chr4/1741429/+ 4p16.3 4p16.3 Exonic hg19 In-frame Intra-chr LGG TCGA-FG-7643-01A Kinase; PRADA
FGFR3_TACC3chr4/1808661/+ chr4/1737000/+ 4p16.3 4p16.3 Exonic hg19 Out-of-frame Intra-chr LUSC TCGA-22-4607-01A Kinase; PRADA
FGFR3_TACC3chr4/1808661/+ chr4/1741429/+ 4p16.3 4p16.3 Exonic hg19 In-frame Intra-chr LUSC TCGA-34-2608-01A Kinase; PRADA
FGFR3_TACC3chr4/1808661/+ chr4/1741429/+ 4p16.3 4p16.3 Exonic hg19 In-frame Intra-chr LUSC TCGA-39-5024-01A Kinase; PRADA
FGFR3_TACC3chr4/1808661/+ chr4/1746245/+ 4p16.3 4p16.3 Exonic hg19 In-frame Intra-chr LUSC TCGA-63-7022-01A Kinase; PRADA
FGFR3_TACC3chr4/1808661/+ chr4/1741429/+ 4p16.3 4p16.3 Exonic hg19 In-frame Intra-chr LUSC TCGA-66-2786-01A Kinase; PRADA

ChiTaRS 2.1

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The fusion gene pair FGFR3--TACC3 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair FGFR3--TACC3 information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
FGFR3-TACC3 bladder cancer FISH,RT-PCR t(4;7) PubMed: 23175443

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
FGFR3-TACC3 FGFR3-TACC3-Isoform1 FGFR3 _ _ 1 TACC3 _ 1 _ GTGACGTCCACCGAcgTAAAGGCGACACAG 23175443 _
FGFR3-TACC3 FGFR3-TACC3-Isoform2 FGFR3 _ _ 1 TACC3 _ 1 _ TGGGGCGGGCCTTCtgGCCCAGGTGCCCTG 23175443 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
FGFR3-TACC3 FGFR3-TACC3-Isoform1 - - - -FGFR3 1) ig
2) I-set
3) Pkinase_Tyr
1) C1-set , IL1 , MHC_I , C2-set , IL34 , SCF , Flt3_lig , Ig_2 , V-set , GP120 , MAM , ig
2) C2-set , FGF , Ig_3 , Pkinase , V-set , C2-set_2 , I-set , LRR_8 , SBP_bac_1 , fn3 , CSF-1 , IL34 , NGF , SCF , Carb_anhydrase , Ig_2 , PDGF , Telethonin
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
TACC3 1) TACC
1) TACC , PAS_3
1) ig
2) I-set
3) Pkinase_Tyr
4) TACC
1) C1-set , IL1 , MHC_I , C2-set , IL34 , SCF , Flt3_lig , Ig_2 , V-set , GP120 , MAM , ig
2) C2-set , FGF , Ig_3 , Pkinase , V-set , C2-set_2 , I-set , LRR_8 , SBP_bac_1 , fn3 , CSF-1 , IL34 , NGF , SCF , Carb_anhydrase , Ig_2 , PDGF , Telethonin
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
4) TACC , PAS_3
FGFR3-TACC3 FGFR3-TACC3-Isoform2 - - - -FGFR3 1) ig
2) I-set
3) Pkinase_Tyr
1) C1-set , IL1 , MHC_I , C2-set , IL34 , SCF , Flt3_lig , Ig_2 , V-set , GP120 , MAM , ig
2) C2-set , FGF , Ig_3 , Pkinase , V-set , C2-set_2 , I-set , LRR_8 , SBP_bac_1 , fn3 , CSF-1 , IL34 , NGF , SCF , Carb_anhydrase , Ig_2 , PDGF , Telethonin
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
TACC3 1) TACC
1) TACC , PAS_3
1) ig
2) I-set
3) Pkinase_Tyr
4) TACC
1) C1-set , IL1 , MHC_I , C2-set , IL34 , SCF , Flt3_lig , Ig_2 , V-set , GP120 , MAM , ig
2) C2-set , FGF , Ig_3 , Pkinase , V-set , C2-set_2 , I-set , LRR_8 , SBP_bac_1 , fn3 , CSF-1 , IL34 , NGF , SCF , Carb_anhydrase , Ig_2 , PDGF , Telethonin
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
4) TACC , PAS_3

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
FGFR3-TACC3 hsa-miR-193b-3phsa-miR-744-5phsa-miR-769-3phsa-miR-18a-3phsa-miR-324-3phsa-miR-324-5phsa-miR-149-5p hsa-miR-100-5phsa-miR-99a-5phsa-miR-26b-5p Microarray,NGS

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
FGFR3-TACC3 NM_000142.4 1) STAT1_HUMAN
2) ZNF263_HUMAN
3) EGR1_HUMAN
4) CTCF_HUMAN
5) HNF4A_HUMAN
6) TFAP2C_HUMAN
7) FOXA1_HUMAN
8) CEBPA_HUMAN
9) ESR1_HUMAN
1) MITF_HUMAN
2) RBL2_HUMAN
3) E2F4_HUMAN
4) ETS1_HUMAN
5) FOS_HUMAN
6) BRG1_HUMAN
7) NR1H3_HUMAN
8) TRIM24_HUMAN
9) VDR_HUMAN
1) 19122651
2) 19887448
3) 20690147
4) 21795385
5) 21646355
6) 21572391
7) 21572391
8) 20219941
9) 21566084

TicDB

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The fusion gene pair FGFR3--TACC3 information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
FGFR3 TACC3 23175443 GTGACGTCCACCGAcgTAAAGGCGACACAG
FGFR3 TACC3 23175443 TGGGGCGGGCCTTCtgGCCCAGGTGCCCTG

TUMOR FUSION Gene Data Portal

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The fusion gene pair FGFR3--TACC3 information is available in TUMOR FUSION Gene Data Portal.
CancerTCGA_barcodeFusionPairEvalue5'Gene_Junction3'Gene_JunctionTierFrameTNWGS_validation
GBM 06-2567-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier4 In-frame 6476 NA
GBM 14-0789-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6477 NA
GBM 14-1823-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6478 non-validated
GBM 14-1829-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6479 NA
LUSC 22-4607-01A FGFR3__TACC3 0.12 4:1808661/1 4:1737000/1 tier1 Out-of-frame 6480 NA
GBM 27-1835-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6481 NA
LUSC 34-2608-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6482 NA
LUAD 38-4630-01A FGFR3__TACC3 0.12 4:1803470/1 4:1746245/1 tier1 Out-of-frame 6483 non-validated
LUSC 39-5024-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6484 NA
LUSC 63-7022-01A FGFR3__TACC3 0.12 4:1808661/1 4:1746245/1 tier3 In-frame 6485 NA
LUSC 66-2786-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6486 NA
GBM 76-4925-01A FGFR3__TACC3 0.12 4:1808661/1 4:1739325/1 tier1 In-frame 6487 NA
LUSC 92-8065-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6488 NA
KIRP A4-7287-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6489 NA
BLCA CF-A3MF-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6490 non-validated
BLCA CF-A3MG-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6491 NA
BLCA CF-A3MH-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6492 NA
BLCA CF-A47S-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6493 NA
BLCA CF-A47T-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6494 NA
BLCA CF-A8HY-01A FGFR3__TACC3 0.12 4:1808661/1 4:1737458/1 tier1 In-frame 6495 NA
HNSC CR-6473-01A FGFR3__TACC3 0.12 4:1808661/1 4:1739325/1 tier1 In-frame 6496 NA
HNSC CV-7100-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6497 non-validated
LIHC DD-A1EK-01A FGFR3__TACC3 0.12 4:1801539/1 4:1746245/1 tier1 Out-of-frame 6498 NA
CESC DS-A3LQ-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6499 NA
KIRP DW-7839-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6500 NA
BLCA E7-A5KE-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6501 NA
LGG FG-7643-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6502 validated
ESCA LN-A5U5-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6503 non-validated
ESCA LN-A9FO-01A FGFR3__TACC3 0.12 4:1808661/1 4:1737458/1 tier1 In-frame 6504 NA
CESC LP-A7HU-01A FGFR3__TACC3 0.12 4:1808661/1 4:1737458/1 tier3 In-frame 6505 NA
LGG P5-A72U-01A FGFR3__TACC3 0.12 4:1808661/1 4:1732899/1 tier1 In-frame 6506 NA
CESC VS-A9UD-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6507 NA
CESC WL-A834-01A FGFR3__TACC3 0.12 4:1808661/1 4:1737458/1 tier1 In-frame 6508 NA
BLCA XF-AAMX-01A FGFR3__TACC3 0.12 4:1795770/1 4:1746245/1 tier1 Out-of-frame 6509 NA
BLCA XF-AAMZ-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier4 In-frame 6510 NA
CESC ZJ-AAXT-01A FGFR3__TACC3 0.12 4:1808661/1 4:1741429/1 tier1 In-frame 6511 NA

FusionCancer

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The fusion gene pair FGFR3--TACC3 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair FGFR3--TACC3 information is not available in ConjoinG Database.

1000Genome

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Fusion gene FGFR3--TACC3 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene FGFR3--TACC3 is found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016)

Bodymap2

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Fusion gene FGFR3--TACC3 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene FGFR3--TACC3 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene FGFR3--TACC3 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair FGFR3--TACC3 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene FGFR3--TACC3 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene FGFR3--TACC3 has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene FGFR3 is a known oncogene according to ONGENE database.
The tail gene TACC3 is not a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene FGFR3 is cancer associated according to Bushman Cancer Gene database.


The tail gene TACC3 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene FGFR3 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene TACC3 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene FGFR3--TACC3 is found in a oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene FGFR3--TACC3 is found in a RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair FGFR3--TACC3 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene FGFR3--TACC3 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene FGFR3--TACC3 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair FGFR3--TACC3 information is available in Klijn Dataset.

Cell lineGene 5'Gene 3'Read evidenceKinaseChromosome 5'Position 5'Chromosome 3'Position 3'Fusion type DNAFusion type RNAFusion protein lengthTissueKnown Fusion
RT-112FGFR3TACC3271Y4180866141741429ScrambleinFrame951Urinary BladderFull fusion known
Hep G2FGFR3TACC32Y4180866141741429ScrambleinFrame951LiverFull fusion known

Fimereli_Dataset

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The fusion gene pair FGFR3--TACC3 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair FGFR3--TACC3 is found in known fusion genelist compiled from literature.

FusionGeneArticleLink
FGFR3--TACC3Development and Verification of an RNA Sequencing (RNA-Seq) Assay for the Detection of Gene Fusions in Tumorshttps://doi.org/10.1016/j.jmoldx.2018.03.007

Cortex_Dataset

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Fusion gene FGFR3--TACC3 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair FGFR3--TACC3 information is not available in ChromothripsisDB database.