EWSR1--NR4A3

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

EWSR1 NR4A3

COSMIC

The fusion gene pair EWSR1--NR4A3 information is available in COSMIC database.

Link
EWSR1--NR4A3

ChimerKB

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The fusion gene pair EWSR1--NR4A3 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
EWSR1_NR4A3-/1613/ -/728/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/1112/ -/554/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/1736+340/ -/728-1696/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/1543/ -/728/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/1543/ -/728-816/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/1736/ -/728/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/1613+309/ -/728-5/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/1613+1052/ -/728-1754/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/1613+1443/ -/728-1542/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/1613+1150/ -/728-286/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/1613+647/ -/728-1438/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/1613+430/ -/728-368/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/1112+1373/ -/554-1631/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/1364/ -/728-1311/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/1483/ -/550/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/1613+1304/ -/554-1806/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/1613+774/ -/728-1056/ Exonic hg19 - - - Receptor; Transcription_Factor Cosmic_recurrent
EWSR1_NR4A3-/-/ -/-/ - hg19 chondrosarcoma - 11679947 Receptor; Transcription_Factor Cosmic_nonrecurrent
EWSR1_NR4A3-/-/ -/-/ - hg19 chondrosarcoma - 9781944 Receptor; Transcription_Factor Cosmic_nonrecurrent
EWSR1_NR4A3-/-/ -/-/ - hg19 chondrosarcoma - 12378528 Receptor; Transcription_Factor Cosmic_nonrecurrent
EWSR1_NR4A3-/-/ -/-/ - hg19 chondrosarcoma - 12598313 Receptor; Transcription_Factor Cosmic_nonrecurrent
EWSR1_NR4A3-/-/ -/-/ - hg19 chondrosarcoma - 8634690 Receptor; Transcription_Factor Cosmic_nonrecurrent
EWSR1_NR4A3-/-/ -/-/ - hg19 chondrosarcoma - 8570200 Receptor; Transcription_Factor Cosmic_nonrecurrent
EWSR1_NR4A3-/-/ -/-/ - hg19 chondrosarcoma - 9060841 Receptor; Transcription_Factor Cosmic_nonrecurrent
EWSR1_NR4A3-/-/ -/-/ - hg19 chondrosarcoma - 16220270 Receptor; Transcription_Factor Cosmic_nonrecurrent
EWSR1_NR4A3-/-/ -/-/ - hg19 chondrosarcoma - 18925568 Receptor; Transcription_Factor Cosmic_nonrecurrent
EWSR1_NR4A3-/-/ -/-/ - hg19 chondrosarcoma - 18587326 Receptor; Transcription_Factor Cosmic_nonrecurrent
EWSR1_NR4A3-/-/ -/-/ - hg19 chondrosarcoma - 18580682 Receptor; Transcription_Factor Cosmic_nonrecurrent
EWSR1_NR4A3-/-/ -/-/ - hg19 chondrosarcoma - 11981607 Receptor; Transcription_Factor Cosmic_nonrecurrent
EWSR1_NR4A3-/-/ -/-/ - hg19 chondrosarcoma - 22743288 Receptor; Transcription_Factor Cosmic_nonrecurrent
EWSR1_NR4A3-/13/ -/650/ Exonic hg18 - - - Receptor; Transcription_Factor TICdb
EWSR1_NR4A3-/60/ -/1393/ Exonic hg18 - - - Receptor; Transcription_Factor TICdb
EWSR1_NR4A3-/338/ -/510/ Exonic hg18 - - - Receptor; Transcription_Factor TICdb
EWSR1_NR4A3-/429/ -/1840/ Exonic hg18 - - - Receptor; Transcription_Factor TICdb
EWSR1_NR4A3-/647/ -/771/ Exonic hg18 - - - Receptor; Transcription_Factor TICdb
EWSR1_NR4A3-/774/ -/1153/ Exonic hg18 - - - Receptor; Transcription_Factor TICdb
EWSR1_NR4A3-/1052/ -/455/ Exonic hg18 - - - Receptor; Transcription_Factor TICdb
EWSR1_NR4A3-/1149/ -/1923/ Exonic hg18 - - - Receptor; Transcription_Factor TICdb
EWSR1_NR4A3-/1303/ -/1545/ Exonic hg18 - - - Receptor; Transcription_Factor TICdb
EWSR1_NR4A3-/1372/ -/1620/ Exonic hg18 - - - Receptor; Transcription_Factor TICdb
EWSR1_NR4A3-/1443/ -/667/ Exonic hg18 - - - Receptor; Transcription_Factor TICdb
EWSR1_NR4A3-/-/ -/-/ - hg18 extraskeletal myxoid chondrosarcoma - 10359536 Receptor; Transcription_Factor OMIM

ChimerPUB

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The fusion gene pair EWSR1--NR4A3 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
EWSR1_NR4A3t(9;22)(q22;q12) / t(9;17)(q22;q11) / / 15262426chondrosarcoma;sarcoma FISH;PCR;RT-PCR - Extraskeletal myxoid chondrosarcoma (EMC) is a rare mesenchymal tumor cytogenetically characterized by reciprocal translocations, such as t(9;22)(q22;q12) and t(9;17)(q22;q11), which result in EWSR1/NR4A3 and TAF15/NR4A3 fusion genes (alias EWS/NOR1, TAF2N/NOR1), respectively. /// " Extraskeletal myxoid chondrosarcoma (EMC) is a rare mesenchymal tumor cytogenetically characterized by reciprocal translocations, such as t(9;22)(q22;q12) and t(9;17)(q22;q11), which result in EWSR1/NR4A3 and TAF15/NR4A3 fusion genes (alias EWS/NOR1, TAF2N/NOR1), respectively. " /// Fourteen tumors with detectable NR4A3 fusion genes (EWSR1-NR4A3.

ChimerSEQ

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The fusion gene pair EWSR1--NR4A3 information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
EWSR1_NR4A3chr22/29683123/ chr9/102587941/ 22q12.2 9q22.33 Exonic hg19 - Inter-chr NA S81242 Receptor; Transcription_Factor ChiTaRs
EWSR1_NR4A3chr22/29688159/ chr9/102589010/ 22q12.2 9q22.33 Exonic hg19 - Inter-chr chomdrosarcoma AF524261 Receptor; Transcription_Factor ChiTaRs

ChiTaRS 2.1

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The fusion gene pair EWSR1--NR4A3 information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human AF524261EWSR1--NR4A3 EWSR122 29683039 29688159 + 1 338 100 NR4A39 102589010 102590480 + 336 567 100
Human S81242EWSR1--NR4A3 EWSR122 29683084 29683123 + 1 40 100 NR4A39 102587941 102588075 + 41 175 99.3

FARE-CAFE

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The fusion gene pair EWSR1--NR4A3 information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
EWSR1-NR4A3 Extraskeletal myxoid chondrosarcoma FISH,PCR t(9;22)(q22-31;q11-12) PubMed:7539287,12378528

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
EWSR1-NR4A3 EWSR1-NR4A3-Isoform1 EWSR1 29692288 1 1 NR4A3 102589506 1 0 AACCCATGATCCACATCTACCTGGACAAGGAAACAGGAAaGATATGTTTTATTAGTTAGAATTGGGATATATATATGTGT 12378528 _
EWSR1-NR4A3 EWSR1-NR4A3-Isoform10 EWSR1 29693410 0 1 NR4A3 102588569 1 0 TTAAGTGTATTTAAGTATGGCCTTTTTCTGGCCAGGCACaCAAAGAGTAAATTTGAGTTTGGCAAAAGAACAGATTGCAC 12378528 _
EWSR1-NR4A3 EWSR1-NR4A3-Isoform2 EWSR1 29693005 0 1 NR4A3 102588885 1 0 AGAGTTTGAAGCTCCAGTGAGCTGAGATTGCACCACTGCaGATTTCATCCCAACAACTGGACAGCAAGATAAGTAACTGG 12378528 _
EWSR1-NR4A3 EWSR1-NR4A3-Isoform3 EWSR1 29692667 0 1 NR4A3 102590303 1 0 ATCTTAACCAGTGTACATTTGCATATAGATAAAACCTTtTCTCTTGTCCCCTATGCAGATATGCCCTGCGTCCAAGCCCAATA 12378528 _
EWSR1-NR4A3 EWSR1-NR4A3-Isoform4 EWSR1 29693508 0 1 NR4A3 102590037 1 0 CCAAGGAGTTCACTAGCAGCCTGGGCAACCTAGTGAGACaGACTTCAAGTTTCCCAAATCTAGTGGAGGACAGGGCAAGG 12378528 _
EWSR1-NR4A3 EWSR1-NR4A3-Isoform5 EWSR1 29693662 0 1 NR4A3 102586234 1 0 CCACTGCACTCCAGCCCGGGCAACAGAGTGAGACTCCCaTTCACGGTTTCCTCCACACACTTCACCACCGGGAGGGAAC 12378528 _
EWSR1-NR4A3 EWSR1-NR4A3-Isoform6 EWSR1 29684496 0 1 NR4A3 102586309 1 0 GATGCTTTATCGTGATGTAAAGAAGATGGTGCCTTGGTTaAAGGGGCTTTGACAGAGGTAGTTATTTCTTCCTAATTTACAAC 12378528 _
EWSR1-NR4A3 EWSR1-NR4A3-Isoform7 EWSR1 29693132 0 1 NR4A3 102589267 1 0 GCTTCCCACCAGCTTATTTTCCTCCTTATGGTAGACAGTgAAATCATCCACTACATCCAATAATTCTCAGCGCCTTCTCACTC 12378528 _
EWSR1-NR4A3 EWSR1-NR4A3-Isoform8 EWSR1 29692788 0 1 NR4A3 102589954 1 0 GGCCATGTCCAGTGGCTTGCACCTGTAATCCCAGCACTTtAGGTTATAGCTGAGGAGCCCACTCCAATTAGTTTATAGGA 12378528 _
EWSR1-NR4A3 EWSR1-NR4A3-Isoform9 EWSR1 29693805 0 1 NR4A3 102588781 1 0 GTGAACAGGGAGTACAGGGGAGTAATTGATGTTCtTGTTGAATGACAGAAAAGAGTAATGGAGAAATCCTAGCGGTGCTG 12378528 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
EWSR1-NR4A3 EWSR1-NR4A3-Isoform1 - - 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
EWSR1 1) RRM_6
2) zf-RanBP
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
NR4A3 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
1) RRM_6
2) zf-RanBP
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
EWSR1-NR4A3 EWSR1-NR4A3-Isoform10 1) RRM_6
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
EWSR1 1) RRM_6
2) zf-RanBP
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
NR4A3 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
1) zf-RanBP
1) ubiquitin , Ras
EWSR1-NR4A3 EWSR1-NR4A3-Isoform2 1) RRM_6
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
EWSR1 1) RRM_6
2) zf-RanBP
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
NR4A3 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
1) zf-RanBP
1) ubiquitin , Ras
EWSR1-NR4A3 EWSR1-NR4A3-Isoform3 1) RRM_6
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
EWSR1 1) RRM_6
2) zf-RanBP
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
NR4A3 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
1) zf-RanBP
1) ubiquitin , Ras
EWSR1-NR4A3 EWSR1-NR4A3-Isoform4 1) RRM_6
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
EWSR1 1) RRM_6
2) zf-RanBP
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
NR4A3 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
1) zf-RanBP
1) ubiquitin , Ras
EWSR1-NR4A3 EWSR1-NR4A3-Isoform5 1) RRM_6
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
EWSR1 1) RRM_6
2) zf-RanBP
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
NR4A3 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
1) zf-RanBP
1) ubiquitin , Ras
EWSR1-NR4A3 EWSR1-NR4A3-Isoform6 - - 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
EWSR1 1) RRM_6
2) zf-RanBP
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
NR4A3 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
1) RRM_6
2) zf-RanBP
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
EWSR1-NR4A3 EWSR1-NR4A3-Isoform7 1) RRM_6
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
EWSR1 1) RRM_6
2) zf-RanBP
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
NR4A3 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
1) zf-RanBP
1) ubiquitin , Ras
EWSR1-NR4A3 EWSR1-NR4A3-Isoform8 1) RRM_6
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
EWSR1 1) RRM_6
2) zf-RanBP
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
NR4A3 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
1) zf-RanBP
1) ubiquitin , Ras
EWSR1-NR4A3 EWSR1-NR4A3-Isoform9 1) RRM_6
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
EWSR1 1) RRM_6
2) zf-RanBP
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
NR4A3 1) zf-C4
2) Hormone_recep
1) zf-C4 , Hormone_recep
2) zf-C4 , Hormone_recep , fn3 , Arm , SRC-1
1) zf-RanBP
1) ubiquitin , Ras

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
EWSR1-NR4A3 hsa-miR-124-3phsa-miR-10b-5phsa-miR-26b-5p hsa-let-7a-5phsa-miR-877-3phsa-miR-615-3phsa-miR-423-3phsa-miR-328-3phsa-miR-362-5phsa-miR-320ahsa-miR-149-5phsa-miR-23b-3phsa-miR-196a-5phsa-miR-100-5phsa-let-7c-5p Report assay,Microarray

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
EWSR1-NR4A3 NM_001163285.1 - 1) HIFALPHA
2) TRIM28_HUMAN
3) MITF_HUMAN
4) STAT1_HUMAN
5) RB1_HUMAN
6) RBL2_HUMAN
7) E2F4_HUMAN
8) PRDM14_HUMAN
9) ETS1_HUMAN
10) EGR1_HUMAN
11) FOS_HUMAN
12) GATA3_HUMAN
13) E2F1_HUMAN
14) TAL1_HUMAN
15) CTCF_HUMAN
16) BRG1_HUMAN
17) HNF4A_HUMAN
18) TFAP2C_HUMAN
19) FOXA1_HUMAN
20) CEBPA_HUMAN
21) ESR1_HUMAN
22) ESR2_HUMAN
23) MEIS1_HUMAN
24) FOXP1_HUMAN
-

TicDB

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The fusion gene pair EWSR1--NR4A3 information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
EWSR1 NR4A3 12378528 AACCCATGATCCACATCTACCTGGACAAGGAAACAGGAAaGATATGTTTTATTAGTTAGAATTGGGATATATATATGTGT
EWSR1 NR4A3 12378528 AGAGTTTGAAGCTCCAGTGAGCTGAGATTGCACCACTGCaGATTTCATCCCAACAACTGGACAGCAAGATAAGTAACTGG
EWSR1 NR4A3 12378528 ATCTTAACCAGTGTACATTTGCATATAGATAAAACCTTtTCTCTTGTCCCCTATGCAGATATGCCCTGCGTCCAAGCCCAATA
EWSR1 NR4A3 12378528 CCAAGGAGTTCACTAGCAGCCTGGGCAACCTAGTGAGACaGACTTCAAGTTTCCCAAATCTAGTGGAGGACAGGGCAAGG
EWSR1 NR4A3 12378528 CCACTGCACTCCAGCCCGGGCAACAGAGTGAGACTCCCaTTCACGGTTTCCTCCACACACTTCACCACCGGGAGGGAAC
EWSR1 NR4A3 12378528 GATGCTTTATCGTGATGTAAAGAAGATGGTGCCTTGGTTaAAGGGGCTTTGACAGAGGTAGTTATTTCTTCCTAATTTACAAC
EWSR1 NR4A3 12378528 GCTTCCCACCAGCTTATTTTCCTCCTTATGGTAGACAGTgAAATCATCCACTACATCCAATAATTCTCAGCGCCTTCTCACTC
EWSR1 NR4A3 12378528 GGCCATGTCCAGTGGCTTGCACCTGTAATCCCAGCACTTtAGGTTATAGCTGAGGAGCCCACTCCAATTAGTTTATAGGA
EWSR1 NR4A3 12378528 GTGAACAGGGAGTACAGGGGAGTAATTGATGTTCtTGTTGAATGACAGAAAAGAGTAATGGAGAAATCCTAGCGGTGCTG
EWSR1 NR4A3 12378528 TCTAGCTAGAAACCTCAGAAAGACACAAATAAGAGCAGTAAAAaGGGAGCAAACTTAAAGTCTCCCTTGCTCGGAAAGAAGC
EWSR1 NR4A3 12378528 TTAAGTGTATTTAAGTATGGCCTTTTTCTGGCCAGGCACaCAAAGAGTAAATTTGAGTTTGGCAAAAGAACAGATTGCAC

TUMOR FUSION Gene Data Portal

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The fusion gene pair EWSR1--NR4A3 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair EWSR1--NR4A3 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair EWSR1--NR4A3 information is not available in ConjoinG Database.

1000Genome

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Fusion gene EWSR1--NR4A3 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene EWSR1--NR4A3 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene EWSR1--NR4A3 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene EWSR1--NR4A3 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene EWSR1--NR4A3 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair EWSR1--NR4A3 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene EWSR1--NR4A3 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene EWSR1--NR4A3 has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene EWSR1 is a known oncogene according to ONGENE database.
The tail gene NR4A3 is not a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene EWSR1 is cancer associated according to Bushman Cancer Gene database.


The tail gene NR4A3 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene EWSR1 is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene NR4A3 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene EWSR1--NR4A3 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene EWSR1--NR4A3 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair EWSR1--NR4A3 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene EWSR1--NR4A3 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene EWSR1--NR4A3 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair EWSR1--NR4A3 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair EWSR1--NR4A3 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair EWSR1--NR4A3 is found in known fusion genelist compiled from literature.

FusionGeneArticleLink
EWSR1--NR4A3The pathology of soft tissue sarcomas (Marta Sbaraglia and Angelo P. Dei Tos; ONCOLOGY IMAGING)https://doi.org/10.1007/s11547-018-0882-7
EWSR1--NR4A3Development and Verification of an RNA Sequencing (RNA-Seq) Assay for the Detection of Gene Fusions in Tumorshttps://doi.org/10.1016/j.jmoldx.2018.03.007

Cortex_Dataset

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Fusion gene EWSR1--NR4A3 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair EWSR1--NR4A3 information is not available in ChromothripsisDB database.