EWSR1--CREB3L1

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

EWSR1 CREB3L1

COSMIC

The fusion gene pair EWSR1--CREB3L1 information is not available in COSMIC database.

ChimerKB

Top
The fusion gene pair EWSR1--CREB3L1 information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

Top
The fusion gene pair EWSR1--CREB3L1 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
EWSR1_CREB3L1- 24441665sarcoma FISH - Recurrent EWSR1-CREB3L1 gene fusions in sclerosing epithelioid fibrosarcoma.. /// "Using FISH, reverse transcription polymerase chain reaction, and/or mRNA sequencing in selected cases, we found recurrent EWSR1-CREB3L1 fusion transcripts by reverse transcription polymerase chain reaction in 3/10 pure SEF cases and splits and deletions of the EWSR1 and/or CREB3L1 genes by FISH in 6 additional cases. "
EWSR1_CREB3L1- 23588368sarcoma FISH - We report 2 cases of LGFMS serendipitously found to harbor a novel alternative EWSR1-CREB3L1 gene fusion, as confirmed by DNA sequencing of reverse transcriptase-polymerase chain reaction products and fluorescence in situ hybridization. /// EWSR1-CREB3L1 gene fusion: a novel alternative molecular aberration of low-grade fibromyxoid sarcoma..
EWSR1_CREB3L1- 25231134fibrosarcoma;sarcoma FISH - While the majority of LGFMS cases are characterized by a FUS-CREB3L1 fusion, both FUS-CREB3L2 and EWSR1-CREB3L1 fusions were recently demonstrated in a small number of LGFMS and SEF/LGFMS hybrid tumors.
EWSR1_CREB3L1- 26449317fibrosarcoma;sarcoma FISH - Fluorescence in situ hybridization assay using dual staining probes detected EWSR1-CREB3L1 fusion in each lesion, which is characteristic molecular findings of SEF.
EWSR1_CREB3L1t(7;16) / 24896634sarcoma - - We present the case of a 6-year-old boy with a deceptively bland spindle cell renal neoplasm found to harbor the EWSR1-CREB3L1 gene fusion. /// Primary low-grade fibromyxoid sarcoma of the kidney in a child with the alternative EWSR1-CREB3L1 gene fusion..
EWSR1_CREB3L1- 25353281solitary fibrous tumor;clear cell sarcoma;sarcoma - - Primary renal sclerosing epithelioid fibrosarcoma: report of 2 cases with EWSR1-CREB3L1 gene fusion..
EWSR1_CREB3L1- 21987447osteosarcoma PCR;ISH - Rapid amplification of cDNA ends revealed exon 6 of the cAMP-responsive element binding protein 3-like 1 gene (CREB3L1, also known as "OASIS," NM_52854.2) fused in-frame to the EWSR1 exon 11, consistent with the EWSR1-CREB3L1 fusion transcript expressed in tumor tissue. /// A novel EWSR1-CREB3L1 fusion transcript in a case of small cell osteosarcoma.. /// "The 3'-end partner and the inferred structure of EWSR1-CREB3L1, however, are different from those of Ewing sarcoma, suggesting different targets of the new oncogene.. " /// "Immunohistochemistry with the same antibody showed signal translocation from the physiologic perinuclear compartment observed in glia and unrelated osteoblasts to nuclei of tumor cells, consistent with the likely function of EWSR1-CREB3L1 as a transcriptional regulator predicted by its structure. "
EWSR1_CREB3L1p11.2;q12.2 / 11p11.2 / 25123073fibrosarcoma;sarcoma ISH - Sclerosing epithelioid fibrosarcoma presenting as intraabdominal sarcomatosis with a novel EWSR1-CREB3L1 gene fusion.. /// We report a case of intraabdominal sclerosing epithelioid fibrosarcoma (SEF) with a t (11;22)(p11.2;q12.2) Ewing sarcoma breakpoint region 1-cAMP-responsive element-binding protein 3-like 1 translocation. /// "This is the first report of ""pure"" or true SEF presenting as intraabdominal sarcomatosis with confirmation of the recently described unique Ewing sarcoma breakpoint region 1-cAMP-responsive element-binding protein 3-like 1 gene fusion in SEF without areas of low-grade fibromyxoid sarcoma. "
EWSR1_CREB3L1- 25990776fibrosarcoma;sarcoma ISH - Sclerosing epithelioid fibrosarcoma (SEF) is a rare fibrosarcoma variant with specific histomorphology and consistent translocation (EWSR1-CREB3L1/2).

ChimerSEQ

Top
The fusion gene pair EWSR1--CREB3L1 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

Top
The fusion gene pair EWSR1--CREB3L1 information is not available in CHITARS database.

FARE-CAFE

Top
The fusion gene pair EWSR1--CREB3L1 information is not available in FARE-CAFE.

TicDB

Top
The fusion gene pair EWSR1--CREB3L1 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

Top
The fusion gene pair EWSR1--CREB3L1 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

Top
The fusion gene pair EWSR1--CREB3L1 information is not available in FusionCancer Database.

ConjoinG

Top
The fusion gene pair EWSR1--CREB3L1 information is not available in ConjoinG Database.

1000Genome

Top
Fusion gene EWSR1--CREB3L1 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

Top
Fusion gene EWSR1--CREB3L1 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

Top
Fusion gene EWSR1--CREB3L1 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

Top
Fusion gene EWSR1--CREB3L1 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

Top
Fusion gene EWSR1--CREB3L1 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

Top
The fusion gene pair EWSR1--CREB3L1 information is not available in Babiceanu_Dataset.

Banned_Dataset

Top
Fusion gene EWSR1--CREB3L1 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

Top
Fusion gene EWSR1--CREB3L1 has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

Top
The head gene EWSR1 is a known oncogene according to ONGENE database.
The tail gene CREB3L1 is not a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

Top
The head gene EWSR1 is cancer associated according to Bushman Cancer Gene database.


The tail gene CREB3L1 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

Top
The head gene EWSR1 is proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene CREB3L1 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

Top
Fusion gene EWSR1--CREB3L1 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

Top
Fusion gene EWSR1--CREB3L1 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

Top
The fusion gene pair EWSR1--CREB3L1 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

Top
Fusion gene EWSR1--CREB3L1 is not found in pancreatic tumor dataset, published here.

GTEx

Top
Fusion gene EWSR1--CREB3L1 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

Top
The fusion gene pair EWSR1--CREB3L1 information is not available in Klijn Dataset.

Fimereli_Dataset

Top
The fusion gene pair EWSR1--CREB3L1 information is not found in Fimereli_Dataset.

Literature

Top
The fusion gene pair EWSR1--CREB3L1 is found in known fusion genelist compiled from literature.

FusionGeneArticleLink
EWSR1--CREB3L1The pathology of soft tissue sarcomas (Marta Sbaraglia and Angelo P. Dei Tos; ONCOLOGY IMAGING)https://doi.org/10.1007/s11547-018-0882-7
EWSR1--CREB3L1The pathology of soft tissue sarcomas (Marta Sbaraglia and Angelo P. Dei Tos; ONCOLOGY IMAGING)https://doi.org/10.1007/s11547-018-0882-7

Cortex_Dataset

Top
Fusion gene EWSR1--CREB3L1 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

Top
The fusion gene pair EWSR1--CREB3L1 information is not available in ChromothripsisDB database.