EWSR1--CREB1

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

EWSR1 CREB1

COSMIC

The fusion gene pair EWSR1--CREB1 information is available in COSMIC database.

Link
EWSR1--CREB1

ChimerKB

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The fusion gene pair EWSR1--CREB1 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
EWSR1_CREB1-/1112/ -/799/ Exonic hg19 - - - Transcription_Factor Cosmic_recurrent
EWSR1_CREB1-/1112+1204/ -/799-992/ Exonic hg19 - - - Transcription_Factor Cosmic_recurrent
EWSR1_CREB1-/1112+1052/ -/799-913/ Exonic hg19 - - - Transcription_Factor Cosmic_recurrent
EWSR1_CREB1-/-/ -/-/ - hg19 clear cell sarcoma - 17000668 Transcription_Factor Cosmic_nonrecurrent
EWSR1_CREB1-/-/ -/-/ - hg19 dermatofibroma - 18094413 Transcription_Factor Cosmic_nonrecurrent
EWSR1_CREB1-/-/ -/-/ - hg19 dermatofibroma - 17724745 Transcription_Factor Cosmic_nonrecurrent
EWSR1_CREB1-/-/ -/-/ - hg19 clear cell sarcoma - 18300804 Transcription_Factor Cosmic_nonrecurrent
EWSR1_CREB1-/-/ -/-/ - hg19 clear cell sarcoma - 19561568 Transcription_Factor Cosmic_nonrecurrent
EWSR1_CREB1-/-/ -/-/ - hg19 clear cell sarcoma - 20598147 Transcription_Factor Cosmic_nonrecurrent

ChimerPUB

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The fusion gene pair EWSR1--CREB1 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
EWSR1_CREB1t(12;16)(q13;p11) / t(12;22)(q13;q12) / t(2;22)(q33;q12) / 19801966ewing sarcoma;histiocytoma;neuroectodermal tumor FISH - Angiomatoid fibrous histiocytoma has been found to harbor three related translocations, a t(12;16)(q13;p11) resulting in a FUS/ATF1 fusion gene, t(12;22)(q13;q12) resulting in a EWSR1/ATF1 fusion, and t(2;22)(q33;q12) resulting in a EWSR1/CREB1 fusion.
EWSR1_CREB1- 22038502fibrous histiocytoma;histiocytoma FISH - Vast majority of the soft tissue cases share the same translocation and the resulting EWSR1-CREB1 gene fusion as background pathogenetic alteration. /// Vast majority of the soft tissue cases share the same translocation and the resulting EWSR1-CREB1 gene fusion as background pathogenetic alteration. /// "Histological, immunohistochemical and FISH analyses of the case revealed pleomorphic phenotype, characteristic immunophenotype and multiplication of the EWSR1-CREB1 fusion gene in the nuclei of the tumor cells." /// "Histological, immunohistochemical and FISH analyses of the case revealed pleomorphic phenotype, characteristic immunophenotype and multiplication of the EWSR1-CREB1 fusion gene in the nuclei of the tumor cells. " /// Angiomatoid fibrous histiocytoma: pleomorphic variant associated with multiplication of EWSR1-CREB1 fusion gene..
EWSR1_CREB1t(12;22)(q13;q12) / 20087159clear cell sarcoma;melanoma;sarcoma FISH - This traditional view is put into perspective by the description of primary CCS of the gastrointestinal tract that may have a variant fusion gene EWSR1-CREB1.
EWSR1_CREB1- 18094413clear cell sarcoma;fibrous histiocytoma;sarcoma;histiocytoma FISH;PCR - EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma.. /// Reverse transcription-PCR showed EWSR1-CREB1 transcript in the case analyzed. /// "We investigated the presence of EWSR1-CREB1, recently found in gastrointestinal clear cell sarcoma, and FUS-CREB1, as well as the already reported FUS-ATF1 and EWSR1-ATF1 in a series of AFH. " /// "We identified the presence of either EWSR1-CREB1 or EWSR1-ATF1 in all the cases, strengthening the concept of chromosomal promiscuity between AFH and clear cell sarcoma. " /// "We investigated the presence of EWSR1-CREB1, recently found in gastrointestinal clear cell sarcoma, and FUS-CREB1, as well as the already reported FUS-ATF1 and EWSR1-ATF1 in a series of AFH."
EWSR1_CREB1- 22588066fibrous histiocytoma;histiocytoma FISH - We describe 2 cases arising endobronchially harboring EWSR1 gene rearrangements by fluorescence in situ hybridization and, respectively, EWSR1-CREB1 and EWSR1-ATF1 gene fusions by reverse transcription polymerase chain reaction. /// Endobronchial pulmonary angiomatoid fibrous histiocytoma: two cases with EWSR1-CREB1 and EWSR1-ATF1 fusions..
EWSR1_CREB1- 25804255fibrous histiocytoma;histiocytoma FISH;PCR;RT-PCR - Angiomatoid fibrous histiocytoma is associated with recurrent chromosomal translocations, leading to characteristic EWSR1-CREB1, EWSR1-ATF1, and, rarely, FUS-ATF1 gene fusions. /// "fluorescence in situ hybridization (FISH), detecting EWSR1 or FUS rearrangements, and reverse transcription-polymerase chain reaction (RT-PCR) for EWSR1-CREB1 and EWSR1-ATF1 fusion transcripts have become routine ancillary tools. " /// "Of 16, 14 (87.5%) had detectable EWSR1-CREB1 or EWSR1-ATF1 fusion transcripts by RT-PCR, whereas 13 (76.5%) of 17 had positive EWSR1 rearrangement with FISH. " /// Seventeen neoplasms (from 16 patients) histologically diagnosed as AFH were assessed for EWSR1 rearrangements or EWSR1-CREB1 and EWSR1-ATF1 fusion transcripts. /// "All 13 of 13 non-AFH control neoplasms failed to show EWSR1-CREB1 or EWSR1-ATF1 fusion transcripts, whereas EWSR1 rearrangement was present in 2 of these 13 cases (which were histopathologically myoepithelial neoplasms). " /// This study shows that EWSR1-CREB1 or EWSR1-ATF1 fusions predominate in AFH (supporting previous reports that FUS rearrangement is rare in AFH) and that RT-PCR has a comparable detection rate to FISH for AFH.
EWSR1_CREB1- 24378390ewing sarcoma;sarcoma FISH;PCR;RT-PCR - Furthermore, the presence of identical gene fusions in completely different sarcoma types (i.e., EWSR1-ATF1, EWSR1-CREB1) or in non-mesenchymal malignancies (epithelial or haematological) has raised skepticism as to their diagnostic utility, and their lack of specificity has been compared to the limitations of other ancillary techniques, in particular immunohistochemistry.
EWSR1_CREB1- 24043718fibrous histiocytoma;histiocytoma FISH - Besides EWSR1 gene rearrangement detected in four cases by fluorescence in situ hybridisation (FISH), EWSR1-CREB1 fusion was confirmed in nine cases, including a schwannoma-like AFH, and EWSR1-ATF1 fusion detected in a myoepithelioma-like AFH. /// "Besides EWSR1 gene rearrangement detected in four cases by fluorescence in situ hybridisation (FISH), EWSR1-CREB1 fusion was confirmed in nine cases, including a schwannoma-like AFH, and EWSR1-ATF1 fusion detected in a myoepithelioma-like AFH. "
EWSR1_CREB1- 25134518sarcoma FISH;PCR - The EWSR1-CREB1 fusion transcript was detected in all cases by reverse-transcription PCR. /// Primary pulmonary myxoid sarcomas with EWSR1-CREB1 translocation might originate from primitive peribronchial mesenchymal cells undergoing (myo)fibroblastic differentiation. /// Primary pulmonary myxoid sarcomas with EWSR1-CREB1 translocation might originate from primitive peribronchial mesenchymal cells undergoing (myo)fibroblastic differentiation.. /// Primary pulmonary myxoid sarcoma (PPMS) is a very rare lung tumor that has recently been shown to harbor an EWSR1-CREB1 translocation.
EWSR1_CREB1- 21997693chondrosarcoma FISH - Of 9 tumors, 7 were shown to harbor a specific EWSR1-CREB1 fusion by reverse transcription-polymerase chain reaction and direct sequencing, with 7 of 10 showing EWSR1 rearrangement by fluorescence in situ hybridization. /// Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion: a new tumor entity. /// Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion: a new tumor entity..
EWSR1_CREB1t(2;22)(q33;q12) / 17724745clear cell sarcoma;fibrous histiocytoma;sarcoma;histiocytoma FISH;PCR;RT-PCR - EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma.. /// "We report for the first time the presence of EWSR1-CREB1 in AFH, which now appears to be the most frequent gene fusion in this tumor. " /// EWSR1-CREB1 is a novel translocation recently described in clear cell sarcoma of the GI tract. /// "By RT-PCR, eight out of nine tumors showed the presence of the EWSR1-CREB1 fusion, while one had an EWSR1-ATF1 transcript. " /// "By RT-PCR, eight out of nine tumors showed the presence of the EWSR1-CREB1 fusion, while one had an EWSR1-ATF1 transcript." /// All cases were subjected to RT-PCR for EWSR1-ATF1 and EWSR1-CREB1. /// Transcriptional profiling was performed in three tumors and their gene expression was compared to five clear cell sarcomas expressing either the EWSR1-ATF1 or EWSR1-CREB1 fusion. /// "To address this, we investigated the presence of FUS-ATF1, EWSR1-ATF1, and the highly related EWSR1-CREB1 fusion in a group of nine AFHs. "
EWSR1_CREB1- 26163185clear cell sarcoma - - EWSR1 gene rearrangements including EWSR1-ATF1 or EWSR1-CREB1 GENE fusions are typically assessed in these tumors.
EWSR1_CREB1- 24715928abdominal neoplasm - - Histologically, it is composed of relatively monomorphic ovoid or round cells with clear to eosinophilic cytoplasm, arranged in sheets and sometimes papillary or alveolar architectures, often with CD68-positive osteoclast-like giant cells in variable numbers, and is associated with EWSR1-CREB1 gene fusions. /// "Histologically, it is composed of relatively monomorphic ovoid or round cells with clear to eosinophilic cytoplasm, arranged in sheets and sometimes papillary or alveolar architectures, often with CD68-positive osteoclast-like giant cells in variable numbers, and is associated with EWSR1-CREB1 gene fusions. "
EWSR1_CREB1- 22510762clear cell sarcoma;fibrous histiocytoma;sarcoma;histiocytoma - - EWSR1-CREB1 and EWSR1-ATF1 are gene fusions of which one or both have now been consistently described in 5 histopathologically and behaviorally diverse neoplasms: angiomatoid fibrous histiocytoma, conventional clear cell sarcoma (of tendons and aponeuroses), clear cell sarcoma-like tumor of the gastrointestinal tract, hyalinizing clear cell carcinoma of the salivary gland, and primary pulmonary myxoid sarcoma. /// " EWSR1-CREB1 and EWSR1-ATF1 are gene fusions of which one or both have now been consistently described in 5 histopathologically and behaviorally diverse neoplasms: angiomatoid fibrous histiocytoma, conventional clear cell sarcoma (of tendons and aponeuroses), clear cell sarcoma-like tumor of the gastrointestinal tract, hyalinizing clear cell carcinoma of the salivary gland, and primary pulmonary myxoid sarcoma. " /// Tumors with EWSR1-CREB1 and EWSR1-ATF1 fusions: the current status.. /// We review the clinicopathologic and molecular features of this group of neoplasms unified by the presence of EWSR1-CREB1 and EWSR1-ATF1 genetic fusions.. /// "yet, the increasing frequency with which EWSR1-CREB1 and EWSR1-ATF1 fusions are being described in separate entities is noteworthy. "
EWSR1_CREB1- 25724038clear cell sarcoma;sarcoma - - The etiology of CCSLGT is unknown, but many studies have shown associations with EWSR1-CREB1 gene fusions and, less frequently, with EWSR1-ATF1 fusions.
EWSR1_CREB1- 25927151fibrous histiocytoma;histiocytoma - - Angiomatoid fibrous histiocytoma is associated with 3 characteristic gene fusions, EWSR1-CREB1 and EWSR1-ATF1, which are also described in other neoplasms, and rarely FUS-ATF1. /// "To review the current status of AFH, discussing putative etiology, histopathology with variant morphology and differential diagnosis, and current genetics, including overlap with other tumors harboring EWSR1-CREB1 and EWSR1-ATF1 fusions. "
EWSR1_CREB1- 23199525fibrous histiocytoma;histiocytoma - - Metastatic angiomatoid fibrous histiocytoma of the scalp, with EWSR1-CREB1 gene fusions in primary tumor and nodal metastasis.. /// Reverse transcription-polymerase chain reaction showed EWSR1-CREB1 fusion transcripts in both primary and metastasis.
EWSR1_CREB1t(12;22)(q13;q12) / t(2;22)(q34;q12) / 19561568clear cell sarcoma FISH;PCR;RT-PCR - Fluorescence in situ hybridization (FISH) analysis using the LSI EWSR1 break-apart probe and a reverse transcription polymerase chain reaction (RT-PCR) assay optimized for formalin-fixed paraffin-embedded tissue to detect all four reported EWSR1/ATF1 clear cell sarcoma chimeric types and the EWSR1/CREB1 variant was performed. /// One case carried a type 2 transcript alone and one case contained an EWSR1/CREB1 transcript. /// Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in clear cell sarcoma (melanoma of soft parts).. /// "In addition, EWSR1-CREB1 was identified in a clear cell sarcoma of soft tissue providing further evidence that this chimeric variant is not exclusive to gastrointestinal clear cell sarcomas and should be included in RT-PCR assays of soft tissue clear cell sarcomas.. "
EWSR1_CREB1- 23320232melanoma;fibrous histiocytoma;histiocytoma - - So far three translocations have been reported to arise in angiomatoid fibrous histiocytoma: FUS-ATF1, EWSR1-CREB1, or EWSR1-ATF1. /// "Revision of the pathology revealed an angiomatoid fibrous histiocytoma, which was later confirmed by a EWSR1-CREB1 translocation with molecular diagnostics. "
EWSR1_CREB1- 23953591clear cell sarcoma;sarcoma - - We examined EWSR1-ATF1 and EWSR1-CREB1 fusions in a single case of clear cell sarcoma with lung metastasis in a 36-year-old Japanese man. /// Clear cell sarcoma is a unique tumor which has EWSR1-ATF1 or EWSR1-CREB1 fusion. /// Clear cell sarcoma is a unique tumor which has EWSR1-ATF1 or EWSR1-CREB1 fusion.
EWSR1_CREB1t(12;22)(q13;q12) / 22406360clear cell sarcoma;melanoma;sarcoma ISH - The presence of type 1, 2, and 3 EWSR1/ATF1 fusion gene transcripts was confirmed by reverse transcriptase polymerase chain reaction analysis, but type 4 and EWSR1/CREB1 fusion gene transcripts were not found.
EWSR1_CREB1t(12;22)(q13;q12) / 18300804clear cell sarcoma;malignant meningioma;microphthalmia - - Reverse transcription-polymerase chain reaction using RNA extracted from formalin-fixed, paraffin-embedded tissues demonstrated transcripts of the EWSR1-ATF1 (31/33) or EWSR1-CREB1 fusion gene (2/33). /// "In addition, the tumors occurring in the gastrointestinal tract may have a variant fusion gene EWSR1-CREB1. "
EWSR1_CREB1- 23252871chondrosarcoma;sarcoma - - Our reverse transcription-polymerase chain reaction using the formalin-fixed, paraffin-embedded tumor tissues detected EWSR1-CREB1 fusion transcript, but could not demonstrate EWSR1-ATF1 fusion or EWSR1/TAF15/TFG-NR4A3 fusion. /// "Our reverse transcription-polymerase chain reaction using the formalin-fixed, paraffin-embedded tumor tissues detected EWSR1-CREB1 fusion transcript, but could not demonstrate EWSR1-ATF1 fusion or EWSR1/TAF15/TFG-NR4A3 fusion. " /// "Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion, resembling extraskeletal myxoid chondrosarcoma: Case report with a review of Literature.. "

ChimerSEQ

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The fusion gene pair EWSR1--CREB1 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair EWSR1--CREB1 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair EWSR1--CREB1 information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
EWSR1-CREB1 Angiomatoid fibrous histiocytoma RT-PCR,FISH _ PubMed:17724745

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
EWSR1-CREB1 EWSR1-CREB1-Isoform1 EWSR1 _ _ 1 CREB1 208439002 1 0 gaaccctataaactActcagttaaaatcagttttgtagttttatat 17000668 _
EWSR1-CREB1 EWSR1-CREB1-Isoform2 EWSR1 _ _ 1 CREB1 _ 1 _ tacgggcagcagaTtgccattacccaggga 17000668 _
EWSR1-CREB1 EWSR1-CREB1-Isoform3 EWSR1 29684175 0 1 CREB1 _ 1 _ ttacattctatccacggggatttctAcagggagaattgtc 17000668 _
EWSR1-CREB1 EWSR1-CREB1-Isoform4 EWSR1 _ _ 1 CREB1 _ 1 _ gggcagcagaTtgccattac 19561568 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
EWSR1-CREB1 EWSR1-CREB1-Isoform1 - - - -EWSR1 1) RRM_6
2) zf-RanBP
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
CREB1 1) pKID
2) bZIP_1
1) KIX
2) bZIP_Maf , bZIP_2 , bZIP_1 , RHD , IRF
1) RRM_6
2) zf-RanBP
3) pKID
4) bZIP_1
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
3) KIX
4) bZIP_Maf , bZIP_2 , bZIP_1 , RHD , IRF
EWSR1-CREB1 EWSR1-CREB1-Isoform2 - - - -EWSR1 1) RRM_6
2) zf-RanBP
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
CREB1 1) pKID
2) bZIP_1
1) KIX
2) bZIP_Maf , bZIP_2 , bZIP_1 , RHD , IRF
1) RRM_6
2) zf-RanBP
3) pKID
4) bZIP_1
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
3) KIX
4) bZIP_Maf , bZIP_2 , bZIP_1 , RHD , IRF
EWSR1-CREB1 EWSR1-CREB1-Isoform3 - - - -EWSR1 1) RRM_6
2) zf-RanBP
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
CREB1 1) pKID
2) bZIP_1
1) KIX
2) bZIP_Maf , bZIP_2 , bZIP_1 , RHD , IRF
1) RRM_6
2) zf-RanBP
3) pKID
4) bZIP_1
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
3) KIX
4) bZIP_Maf , bZIP_2 , bZIP_1 , RHD , IRF
EWSR1-CREB1 EWSR1-CREB1-Isoform4 - - - -EWSR1 1) RRM_6
2) zf-RanBP
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
CREB1 1) pKID
2) bZIP_1
1) KIX
2) bZIP_Maf , bZIP_2 , bZIP_1 , RHD , IRF
1) RRM_6
2) zf-RanBP
3) pKID
4) bZIP_1
1) RRM_6 , RRM_5 , RRM_1 , NUDIX_2 , Vinculin , zf-RNPHF
2) ubiquitin , Ras
3) KIX
4) bZIP_Maf , bZIP_2 , bZIP_1 , RHD , IRF

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
EWSR1-CREB1 hsa-miR-34b-5phsa-miR-103a-3phsa-miR-182-5phsa-miR-203ahsa-miR-200b-3phsa-miR-34b-3phsa-miR-122-5p hsa-let-7a-5phsa-miR-877-3phsa-miR-615-3phsa-miR-423-3phsa-miR-328-3phsa-miR-362-5phsa-miR-320ahsa-miR-149-5phsa-miR-23b-3phsa-miR-196a-5phsa-miR-100-5phsa-let-7c-5p Report assay,Western Blot,Microarray,qPCR

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
EWSR1-CREB1 NM_001163285.1 - 1) MITF_HUMAN
2) RB1_HUMAN
3) STAT1_HUMAN
4) RBL2_HUMAN
5) E2F4_HUMAN
6) PRDM14_HUMAN
7) ESTROGEN RECEPTOR ALPHA_HUMAN
8) ETS1_HUMAN
9) EGR1_HUMAN
10) FOS_HUMAN
11) GATA2_HUMAN
12) E2F1_HUMAN
13) CTCF_HUMAN
14) BRG1_HUMAN
15) TFAP2C_HUMAN
16) FOXA1_HUMAN
17) CEBPA_HUMAN
18) ESR1_HUMAN
19) FOXP1_HUMAN
20) SPI1_HUMAN
-

TicDB

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The fusion gene pair EWSR1--CREB1 information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
EWSR1 CREB1 17000668 gaaccctataaactActcagttaaaatcagttttgtagttttatat
EWSR1 CREB1 17000668 tacgggcagcagaTtgccattacccaggga
EWSR1 CREB1 17000668 ttacattctatccacggggatttctAcagggagaattgtc
EWSR1 CREB1 19561568 gggcagcagaTtgccattac

TUMOR FUSION Gene Data Portal

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The fusion gene pair EWSR1--CREB1 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair EWSR1--CREB1 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair EWSR1--CREB1 information is not available in ConjoinG Database.

1000Genome

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Fusion gene EWSR1--CREB1 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene EWSR1--CREB1 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene EWSR1--CREB1 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene EWSR1--CREB1 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene EWSR1--CREB1 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair EWSR1--CREB1 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene EWSR1--CREB1 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene EWSR1--CREB1 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene EWSR1 is a known oncogene according to ONGENE database.


The tail gene CREB1 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene EWSR1 is cancer associated according to Bushman Cancer Gene database.


The tail gene CREB1 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene EWSR1 is proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene CREB1 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene EWSR1--CREB1 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene EWSR1--CREB1 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair EWSR1--CREB1 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene EWSR1--CREB1 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene EWSR1--CREB1 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair EWSR1--CREB1 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair EWSR1--CREB1 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair EWSR1--CREB1 is found in known fusion genelist compiled from literature.

FusionGeneArticleLink
EWSR1--CREB1The pathology of soft tissue sarcomas (Marta Sbaraglia and Angelo P. Dei Tos; ONCOLOGY IMAGING)https://doi.org/10.1007/s11547-018-0882-7
EWSR1--CREB1The pathology of soft tissue sarcomas (Marta Sbaraglia and Angelo P. Dei Tos; ONCOLOGY IMAGING)https://doi.org/10.1007/s11547-018-0882-7

Cortex_Dataset

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Fusion gene EWSR1--CREB1 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair EWSR1--CREB1 information is not available in ChromothripsisDB database.