EWS--ERG

Hyperlinks to databases below
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1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
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GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

EWS ERG

COSMIC

The fusion gene pair EWS--ERG information is not available in COSMIC database.

ChimerKB

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The fusion gene pair EWS--ERG information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair EWS--ERG information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
EWS_ERGt(11;22)(q24;q12) / t(2;11;22) / t(12;22) / 9242212ewing sarcoma FISH - Using fluorescence in situ hybridization (FISH) on interphase nuclei or metaphases, we report here the characterization of particular karyotypes in Ewing tumors, namely a complex t(2;11;22) translocation, a variant t(12;22) translocation, and one Ewing tumor without specific rearrangements but with an EWS/ERG fusion gene demonstrated by molecular analysis. /// and (4) to show that the generation of an EWS/ERG fusion gene cannot be obtained through a simple balanced translocation.. /// Multiple chromosomal mechanisms generate an EWS/FLI1 or an EWS/ERG fusion gene in Ewing tumors..
EWS_ERGt(19;22) / 18295659ewing sarcoma;sarcoma FISH - We report an unusually aggressive case of ES with an EWS-ERG fusion gene that appeared to be a result of a simple balanced and reciprocal translocation, t(19;22)(q13.2;q12.2). /// EWS-ERG Ewing sarcoma (ES) gene fusions often result from complex chromosomal rearrangements. /// "Complex rearrangement of chromosomes 19, 21, and 22 in Ewing sarcoma involving a novel reciprocal inversion-insertion mechanism of EWS-ERG fusion gene formation: a case analysis and literature review.. " /// "Molecular cytogenetic investigation, using systematic analysis with locus-specific probes, identified the cognate genomic breakpoints within chromosome 21 and 22, mandatory for the excision and exchange of both 3'ERG and 3'EWS, resulting in the formation of the EWS-ERG fusion gene present on the der(22). " /// "Subsequent molecular investigation of the primary tumor, the metastasis, and a cell line generated from this ES permitted reconstruction of each genomic step in the evolution of this complex EWS-ERG fusion. "
EWS_ERGt(21;22) / t(11;22)(q23;q12) / t(21;22)(q22;q12) / t(7;22)(p22;q12) / 15899394ewing sarcoma;sarcoma FISH - This finding suggests that the insertion of chromosome 21 is another mechanism that could lead to EWS-ERG gene fusion.
EWS_ERGt(1;16) / t(11;22)(q24q12) / t(11;22) / t(1;16) / t(21;22) / 8625264ewing sarcoma;sarcoma FISH;PCR;RT-PCR - Using the RT-PCR technique, a variant EWS/ERG fusion transcript was noted, resulting from a t(21;22) chromosomal rearrangement which recently demonstrated in roughly 10% of ET. /// Association of the additional translocation der(16)t(1;16) with the variant EWS/ERG rearrangement in a case of cytogenetically inconspicuous chromosome 22.. /// This is the first reported combination of t(1;16) with the EWS/ERG rearrangement. /// "However, data on possible biologic differences in EWS/FLI-1 versus EWS/ERG expressing ET are as yet unavailable. "
EWS_ERGt(21;22)(q22;q12) / 9071576ewing sarcoma;leukemia;sarcoma FISH;PCR;RT-PCR - Although 10% of Ewing-family tumors express the EWS-ERG fusion transcript, there have been no reports on tumors with t(21;22)(q22;q12) identified by banding cytogenetics. /// Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis performed on the tumor and direct sequencing of the products identified the EWS-ERG fusion transcript. /// EWS-ERG fusion transcript produced by chromosomal insertion in a Ewing sarcoma..
EWS_ERGt(11;22)(q24;q12) / 10574242esthesioneuroblastoma FISH - Neither EWS/FLI-I, EWS/ERG and EWS/FEV fusion genes nor MIC2 expression were found in any tumour, whereas trisomy 8 was found in one case only.
EWS_ERGt(11;22)(q24;q12) / t(21;22)(q22;q12) / 15714060neuroectodermal tumor;ewing sarcoma;sarcoma FISH;PCR;RT-PCR - RT-PCR detected 13 (72%) EWS-FLI-1 fusions (type I=10, type II=3) and 2 (11%) EWS-ERG fusions.
EWS_ERGt(11;22)(q24;q12) / t(21;22)(q22;q12) / 9496833neuroectodermal tumor - - Ewing sarcoma and other peripheral primitive neuroectodermal tumors (pPNETs) display limited neural differentiation and are thought to have a neural crest origin Greater than 95% of these tumors share common t(11;22)(q24;q12) ort(21;22)(q22;q12) chromosomal translocations leading to ES/FLI1 or EWS/ERG gene fusions, respectively.
EWS_ERG- 19013896ewing sarcoma;sarcoma - - ES, a tumor characterized by chromosomal translocations that originate gene fusions (EWS-FLI1, EWS-ERG), is an example of a good chemotherapy responder tumor whose survival rate shows a plateau in recent years.
EWS_ERGt(16;21) / t(16;21)(p11;q22) / t(12;16)(q13;p11) / 8187069liposarcoma;myeloid leukemia;leukemia;ewing sarcoma;sarcoma - - Thus, the TLS/FUS-ERG gene fusion in t(16;21) leukemia is predicted to produce a protein that is very similar to the EWS-ERG chimeric protein responsible for Ewing's sarcoma..
EWS_ERGt(11;22) / t(21;22) / 9586882ewing sarcoma PCR;RT-PCR - RNA was extracted from nucleated cells from PB and BM and a nested reverse-transcriptase polymerase chain reaction (RT-PCR) was performed to search for EWS-FLI-1 or EWS-ERG fusion transcripts that resulted from the t(11;22) or t(21;22) translocations, respectively.
EWS_ERG- 10561219synovial sarcoma;rhabdomyosarcoma;ewing sarcoma;sarcoma - - We selected 30 cases of Ewing's sarcoma with the EWS-ERG gene fusion and 106 cases with the EWS-FLI1 fusion. /// EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma.. /// "We investigated whether the two alternative gene fusion products, EWS-FLI1 and EWS-ERG, define different clinical subsets within the Ewing's sarcoma family of tumors. "
EWS_ERG- 10749119ewing sarcoma - - We show that relative to the control, NIH-3T3 cell lines stably transfected with the EWS-FLI1, EWS-ERG, or EWS-ETV1 gene fusion express reduced levels of TGF-beta RII mRNA and protein, and that these cell lines have reduced TGF-beta sensitivity. /// "EWS-FLI1, EWS-ERG, and EWS-ETV1 oncoproteins of Ewing tumor family all suppress transcription of transforming growth factor beta type II receptor gene.. " /// "Here, we also examined effects of EWS-ETV1 and EWS-ERG on expression of the TGF-beta RII gene. " /// "These results indicate that transcriptional repression of TGF-beta RII is an important target of the EWS-FLI1, EWS-ERG, or EWS-ETV1 oncogene, and that EWS-ets fusion proteins may function as dominant negative forms of ets transcription factors.. "
EWS_ERGt(2;13) / t(11;22) / t(21;22) / 17431644ewing sarcoma;rhabdomyosarcoma;sarcoma;medulloblastoma PCR;RT-PCR - Standard cytogenetic analyses and RT-PCR testing for the classic gene rearrangements seen in RMS [t(2;13)-PAX3/FKHR] and EWS ([t(11;22) & t(21;22)-EWS/FLI-1 & EWS/ERG), were used for characterization of the MEM, with gene expression microarray analyses on all tumor types.
EWS_ERGt(11;22)(q24;q12) / t(2;22)(p25;q12) / 11474174ewing tumor FISH;PCR;RT-PCR - In contrast to the EWS/FLI1 fusion which is represented by a t(11;22)(q24;q12), EWS/ERG fusions are frequently cytogenetically not detectable. /// EWS/ERG transcripts were detected by RT-PCR in all cases. /// Fine-mapping of cytogenetically undetectable EWS/ERG fusions on DNA fibers of Ewing tumors.. /// This finding suggests that EWS/ERG fusions in ETs may be generated by an inversion of the ERG gene or a part thereof followed by an insertion into the EWS gene on the der(22). /// "In contrast, co-hybridization of probe PT1526 containing the ERG breakpoint region with G9 revealed the juxtaposition of two signals per interphase nucleus in all three cases indicating the EWS/ERG fusions. "
EWS_ERGt(11;22)(q24;q12) / t(22;21)(q22;q12) / 19243895ewing sarcoma;sarcoma - - However, molecular analyses failed to show the presence of the EWS/FLI-1 and EWS/ERG fusion transcripts, indicative of the most common translocations, i.e., t(11;22)(q24;q12) and t(22;21)(q22;q12), occurring in this tumor family.
EWS_ERGt(15;22) / 10209495- - - A novel EWS-ERG rearrangement generating two hybrid mRNAs in a peripheral primitive neuroectodermal tumour (pPNET) with a t(15;22) translocation.. /// "To the authors' knowledge, this is the first report of the detection of two hybrid EWS-ERG mRNAs within the same tumour.. "
EWS_ERGt(11;22)(q24;q12) / t(21;22)(q21;q12) / 9646032ewing sarcoma;neuroectodermal tumor;sarcoma PCR;RT-PCR - Most Ewing tumors (ET), including Ewing sarcomas, peripheral primitive neuroectodermal tumors (PNET), and Askin's tumors, can be defined according to the specific chromosomal translocations t(11;22)(q24;q12) (EWS-FLI-1) or t(21;22)(q21;q12) (EWS-ERG). /// Molecular diagnosis of Ewing tumors: improved detection of EWS-FLI-1 and EWS-ERG chimeric transcripts and rapid determination of exon combinations..
EWS_ERGt(11;22)(q24;q12) / 8076344ewing sarcoma;sarcoma - - Elevated steady state levels of the EWS/ERG fusion gene transcript were detected in the #5838 cell line.
EWS_ERGt(1;16) / t(11,22)(q24;q12) / t(1;16) / t(1;16) / / 9049824- - - The cytogenetic hallmark of the Ewing family of tumors is t(11,22)(q24;q12) in its simple, complex or variant forms and/or its molecular equivalent EWS/FLI, EWS/ERG rearrangement.
EWS_ERGt(21;22)(q22;q12) / 15974803sarcoma - - The EWS-ERG fusion protein is found in human sarcomas with the chromosomal translocation t(21;22)(q22;q12), where the translocation is considered to be an initiating event in sarcoma formation within uncommitted mesenchymal cells, probably long-lived progenitors capable of self renewal. /// "To assess whether EWS-ERG can be a tumour initiator in cells other than mesenchymal cells, we have analysed Ews-ERG fusion protein function in a cellular environment not typical of that found in human cancers, namely, committed lymphoid cells. "
EWS_ERG- 18459906intestinal cancer - - The authors report on a child who presented with intracranial bleeding secondary to a nonmetastatic tentorial ESFT confirmed by detection of the fusion gene EWS-ERG.
EWS_ERG- 15643511ewing sarcoma;sarcoma - - Although fusion genes EWS-FLI1 and EWS-ERG were undetectable, PES was still considered to be the most likely diagnosis.
EWS_ERGt(11;22)(q24;q12) / t(21;22)(q22;q12) / t(11;22) / t(21;22) / 8617485neuroectodermal tumor;ewing sarcoma;sarcoma PCR;RT-PCR - In the same material, the authors have evaluated the presence of t(11;22) or t(21;22) transcripts (EWS/FLI-1 and EWS/ERG, respectively) by RT-PCR.
EWS_ERGt(21;22) / 12554743ewing sarcoma;sarcoma - - A specific t(21;22) chromosomal translocation creates the chimeric EWS/ERG gene in some cases of Ewing's sarcoma. /// "We found that expression of EWS/ERG, but not wild-type ERG, transactivated the COL11A2 promoter and that this transactivation required not only the N-terminal region of EWS but also an intact DNA-binding domain from ERG. " /// "Taken together, these findings indicate that the COL11A2 gene is regulated both by potential ERG association with a histone deacetylase complex and by direct EWS/ERG recruitment of RNA polymerase II.. " /// "Treatment of cells with the histone deacetylase inhibitor trichostatin A enabled ERG to transactivate the COL11A2 promoter, therefore abolishing the differential effects of EWS/ERG and ERG. " /// "We found that both the EWS/ERG and COL11A2 genes are expressed in the Ewing's sarcoma cell line, CADO-ES1. " /// "EWS/ERG, but not wild-type ERG, bound to RNA polymerase II. " /// COL11A2 collagen gene transcription is differentially regulated by EWS/ERG sarcoma fusion protein and wild-type ERG.. /// "Electrophoretic mobility shift assay using COL11A2 promoter sequence showed involvement of EWS/ERG in the formation of DNA-protein complexes, and chromatin immunoprecipitation assay revealed direct interaction between COL11A2 promoter and EWS/ERG fusion protein in vivo. " /// "To investigate a potential role for EWS/ERG in COL11A2 gene expression, we characterized the COL11A2 promoter and tested the ability of wild-type ERG and EWS/ERG sarcoma fusion protein to transactivate COL11A2 promoter using a luciferase assay. " /// "In the resultant EWS/ERG fusion protein, the N-terminal part of the ETS family protein ERG is replaced by the N terminus of the RNA-binding protein EWS. "
EWS_ERGt(16;21)(p11;q22) / t(16;21) / 10523652acute myeloid leukemia;myeloid leukemia;leukemia;ewing sarcoma;sarcoma - - The FUS (TLS)-ERG chimeric protein associated with t(16;21)(p11;q22) acute myeloid leukemia is structurally similar to the Ewing's sarcoma chimeric transcription factor EWS-ERG. /// "Although EWS intrinsically possessed the TR2 domain, the EWS-ERG construct employed lacked the EWS sequence containing this domain. " /// We found that both FUS-ERG and EWS-ERG could induce anchorage-independent proliferation of the mouse fibroblast cell line NIH 3T3.
EWS_ERGt(11;22)(q24;q12) / t(21;22)(q22;q12) / 8605035ewing sarcoma;sarcoma - - Furthermore, the expression of EWS/FLI-1 or EWS/ERG chimeric genes was found to be generated through a t(11;22)(q24;q12) or a t(21;22)(q22;q12) translocation.
EWS_ERGt(21;22)(q22;q12) / 11441341ewing sarcoma;sarcoma FISH;PCR;RT-PCR - By RT-PCR, the EWS-ERG fusion transcript was defined as type 9e.
EWS_ERGt(21;22)(q22;q12) / 8707406ewing tumor PCR;RT-PCR - No EWS/ERG fusion transcript could be detected with previously reported RT-PCR primers. /// An EWS/ERG fusion with a truncated N-terminal domain of EWS in a Ewing's tumor..
EWS_ERG- 24293381ewing sarcoma FISH;PCR;RT-PCR - The aims of this study were (1) to present the diverse clinicopathological and molecular profile of EFTs in our settings, (2) to identify a pragmatic approach for diagnosing EFTs, especially for application of ancillary techniques, namely RT-PCR for specific transcripts (EWS-FLI1, EWS-ERG) and FISH for EWSR1 gene rearrangement, in certain cases and (3) to show the utility of tissue microarray in establishing a new FISH test. /// "Fifty five tumors were EWS-FLI1 positive, while a single tumor was EWS-ERG positive. "
EWS_ERG- 9706984neuroectodermal tumor;desmoplastic small round cell tumor;ewing sarcoma;sarcoma - - This is the third report of a hybrid tumor with features of the desmoplastic small round cell tumor and Ewing's sarcoma/peripheral primitive neuroectodermal tumor, and the first one with the EWS/ERG fusion gene. /// Intraabdominal desmoplastic small round cell tumor with EWS/ERG fusion transcript.. /// "Reverse transcription polymerase chain reaction revealed a EWS/ERG fusion transcript characteristic of the Ewing's sarcoma/peripheral primitive neuroectodermal tumor group of tumors, rather than the EWS/WT1 chimeric transcript typical of the desmoplastic small round cell tumor. "
EWS_ERG- 7524604ewing sarcoma;sarcoma PCR;RT-PCR - Two tumours expressed EWS/ERG fusion transcripts involving EWS exon 7 and ERG exon 6. /// We have analysed tumour-derived material from 30 ET patients with well-documented clinical course (18 with localised and 12 with metastatic disease at diagnosis) for the presence of EWS/FLI-1 or EWS/ERG RNA.
EWS_ERG- 16834905neuroectodermal tumor;ewing sarcoma;sarcoma FISH;PCR;RT-PCR - EWS-ERG fusion transcript was not detected in any of the cases.
EWS_ERG- 21384537ewing sarcoma;leukemia;sarcoma - - EWS-FLI1 fusion genes were detected in 17 cases (74%) and EWS-ERG in six cases (26%).
EWS_ERG- 15500711leiomyosarcoma PCR;RT-PCR - Of the 25 cases of ES/pPNET, 19 were positive for EWS-FLI1 fusion transcript and 1 for EWS-ERG fusion transcript.
EWS_ERG- 11064357histiocytoma;soft tissue sarcoma PCR;RT-PCR - Of the four cases of Ewing sarcoma, two had an EWS-FLI1 fusion transcript and one had an EWS-ERG fusion transcript.
EWS_ERG- 16157025small cell carcinoma;rhabdomyosarcoma;neuroectodermal tumor;desmoplastic small round cell tumor;ewing sarcoma PCR;RT-PCR - To apply these molecular markers to commonly available archival materials, we evaluated the feasibility of detecting EWS-Ets including EWS-Fli1 and EWS-ERG fusion transcripts in paraffin-embedded tissues and its diagnostic value for detecting ES/pPNET. /// A nested reverse transcriptase-polymerase chain reaction (RT-PCR)-based assay was performed to detect the EWS-Fli1 and EWS-ERG fusion transcripts.
EWS_ERGt(11;22)(q24;q12) / t(21;22)(q22;q12) / t(11;22)(p13;q12) / t(2;13)(q35;q14) / t(1;13)(p36;q14) / p11;q11 / t(11;22) / t(21;22) / t(2;13) / t(1;13) / 9293447desmoplastic small round cell tumor PCR;RT-PCR - 3 ETs were lacking EWS/FLI-1 or EWS-ERG fusion products.
EWS_ERG- 20231617neuroblastoma PCR;RT-PCR - The detection of the EWS-FLI1 (20/25) and EWS-ERG (4/25) fusion transcripts resolved 24 of 25 cases of Ewing sarcoma/PNET.
EWS_ERG- 8648380ewing sarcoma;sarcoma PCR;RT-PCR - Fifteen cases of EWS-ERG rearrangement were identified.
EWS_ERGt(21;22) / t(11;22)(q24;q12) / t(21;22)(q22;q12) / 8162068ewing sarcoma;sarcoma - - Identical EWS nucleotide sequences found in the EWS/FLI-1 fusion transcripts are fused to portions of ERG encoding an ETS DNA-binding domain resulting in expression of a hybrid EWS/ERG protein.
EWS_ERG- 11471459- PCR - With this method we have correctly determined known as well as unknown ET-associated EWS-FLI and EWS-ERG translocations in appropriate specimens. /// "Use of our consensus primers eliminates the need for separate PCRs to amplify EWS-FLI and EWS-ERG translocation junctions, and because direct sequencing is used for confirming the identity of the amplification product, the accuracy of detection becomes 100%. " /// The method might also accurately diagnose ET-associated translocations other than EWS-FLI and EWS-ERG translocations..
EWS_ERG- 17334332synovial sarcoma;rhabdomyosarcoma;ewing sarcoma;sarcoma PCR;RT-PCR - Of the 43 samples with translocations detected, 26 (60%) had an EWS-FLI1 type 1 translocation, 13 (30%) had an EWS-FLI1 type 2 translocation, 3 (7%) had an EWS-ERG translocation, 1 had an EWS-ETV1 translocation, and 1 sample had both an EWS-FLI1 type 1 and type 2 translocation. /// "Real-time RT-PCR assays specific for Ewing's sarcoma (EWS-FLI1, EWS-ERG, EWS-ETV1, EWS-ETV4, and EWS-FEV), synovial sarcoma (SYT-SSX1 and SYT-SSX2), and rhabdomyosarcoma (PAX3-FKHR and PAX7-FKHR) were tested across the samples. "
EWS_ERGt(7;22)(p22;q12) / 7700648neuroectodermal tumor;ewing sarcoma;sarcoma - - Identical EWS nucleotide sequences found in the majority of EWS-FLI1 and EWS-ERG chimeric transcripts are fused to a portion of ETV1 encoding an ETS domain with sequence specific DNA-binding activity.
EWS_ERG- 17700534ewing sarcoma;sarcoma - - siRNA targeting EWS-Fli1 attenuated fenretinide-induced cell death in cell lines expressing EWS-Fli1, but not EWS-ERG.
EWS_ERG- 21623206small cell carcinoma - - This was excluded by molecular studies that showed no evidence of EWS/FLI-1 or EWS/ERG translocation..
EWS_ERG- 9475198neuroectodermal tumor;ewing sarcoma;sarcoma PCR;RT-PCR - This diagnosis was established by detection of EWS/ERG fusion transcript through reverse transcription polymerase chain reaction (RT-PCR) with nested primers.
EWS_ERG- 15628889ewing sarcoma;neuroectodermal tumor;sarcoma - - A multiplex real-time polymerase chain reaction assay detected an EWS-ERG fusion.
EWS_ERG- 7530783rhabdomyosarcoma;desmoplastic small round cell tumor;ewing sarcoma;sarcoma - - EWS-FLI1 or EWS-ERG fusions were detected in six of eight Ewing's sarcomas and one of seven undifferentiated sarcomas. /// "These assays detect PAX3-FKHR and PAX7-FKHR chimeric transcripts in alveolar rhabdomyosarcoma, EWS-FLI1 and EWS-ERG chimeric transcripts in Ewing's sarcoma, and EWS-WT1 chimeric transcripts in desmoplastic small round cell tumor. "
EWS_ERG- 17690209- - - EFTs show fusions of EWS with a gene of the ETS family of transcription factors, either EWS-FLI1 (90 to 95%) or EWS-ERG (5 to 10%).
EWS_ERGt(11;22)(q24;q12) / t(21;22)(q22;q12) / 7591257neuroectodermal tumor;ewing sarcoma;sarcoma PCR;RT-PCR - We detected 2 types of EWS-ERG chimeric mRNA in 2 ES cell lines and 1 PNET tumor sample in addition to 4 types of EWS-FLI-1 chimeric mRNA in 11 ESs (4 cell lines and 7 tumor samples) and 4 PNETs (2 cell lines and 2 tumor samples). /// EWS-FLI-1 and EWS-ERG chimeric mRNAs in Ewing's sarcoma and primitive neuroectodermal tumor..
EWS_ERG- 9738976ewing sarcoma;sarcoma - - EWS-FLI-1, EWS-ERG, EWS-ETV1 and EWS-FEV.
EWS_ERG- 7599072- - - EWS/FLI-1 and EWS/ERG transcripts being observed in eight and two cases respectively.
EWS_ERG- 12736494neuroectodermal tumor;ewing sarcoma;sarcoma PCR;RT-PCR - Different chimeric genes, EWS-ERG and EWS-ETV1, were detected in the other two ES samples.
EWS_ERG- 15846078fibrosarcoma;sarcoma - - Additionally through use of an antisense oligonucleotide for EWS-ERG in the W-ES EFT cell line, laminin beta3 protein was reduced coordinately with EWS-ERG fusion protein expression.
EWS_ERG- 20308673neuroectodermal tumor;ewing sarcoma;sarcoma - - Results After exclusion of noninformative patients, 565 patients were entered into the prognostic factor analysis comparing type 1 (n = 296), type 2 (n = 133), nontype 1/nontype 2 EWS-FLI1 (n = 91) and EWS-ERG fusions (n = 45).

ChimerSEQ

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The fusion gene pair EWS--ERG information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair EWS--ERG information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair EWS--ERG information is not available in FARE-CAFE.

TicDB

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The fusion gene pair EWS--ERG information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair EWS--ERG information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair EWS--ERG information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair EWS--ERG information is not available in ConjoinG Database.

1000Genome

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Fusion gene EWS--ERG has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene EWS--ERG is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene EWS--ERG is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene EWS--ERG is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene EWS--ERG was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair EWS--ERG information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene EWS--ERG is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene EWS--ERG has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene EWS is a known oncogene according to ONGENE database.


The tail gene ERG is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene EWS is cancer associated according to Bushman Cancer Gene database.


The tail gene ERG is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene EWS is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene ERG is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene EWS--ERG is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene EWS--ERG is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair EWS--ERG information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene EWS--ERG is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene EWS--ERG has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair EWS--ERG information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair EWS--ERG information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair EWS--ERG information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene EWS--ERG is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair EWS--ERG information is not available in ChromothripsisDB database.