ETV6--ABL2

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

ETV6 ABL2

COSMIC

The fusion gene pair ETV6--ABL2 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair ETV6--ABL2 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
ETV6_ABL2-/0/ -/0/ Exonic hg18 - - - Kinase; Oncogene; TICdb
ETV6_ABL2-/-/ -/-/ - hg18 acute myeloblastic leukemia - 10706884 Kinase; Oncogene; OMIM

ChimerPUB

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The fusion gene pair ETV6--ABL2 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
ETV6_ABL2t(1;10;12) / t(15;17)(q22;q21) / t(1;12)(q25;p13) / 12406085T ALL - - Identical ETV6-ABL2 fusion transcripts have been reported in an acute myeloid leukaemia (AML) M3 cell line, carrying both a t(15;17)(q22;q21) and a t(1;12)(q25;p13) with unusual inducible differentiation to eosinophils, and in a patient with AML-M4eo. /// Identification of an ETV6-ABL2 fusion transcript in combination with an ETV6 point mutation in a T-cell acute lymphoblastic leukaemia cell line.. /// "Using reverse transcription polymerase chain reaction with primers complementary to ETV6 and ABL2, two ETV6-ABL2 fusion transcripts were identified in MT-ALL which resulted from alternative splicing of an ABL2 exon. " /// "The fusion transcripts code for putative ETV6-ABL2 fusion proteins containing the pointed domain of ETV6 and almost the complete ABL2 protein, including the SH2, SH3 domains and the protein tyrosine kinase domain (PTK). "
ETV6_ABL2- 22373549acute lymphoblastic leukemia;T ALL;lymphoblastic leukemia;leukemia PCR;RT-PCR - ETV6-RUNX1 were observed in six cases (3.4%), ETV6-JAK2 in three cases (1.7%), ETV6-ABL1 in two cases (1.1%), and ETV6-ABL2, ETV6-NCOA2, ETV6-SYK, and PAX5-ETV6 each in one case (0.6%).

ChimerSEQ

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The fusion gene pair ETV6--ABL2 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair ETV6--ABL2 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair ETV6--ABL2 information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
ETV6-ABL2 acute myeloid leukemia M4 RT-PCR t(1;12)(q25;p13) PubMed: 10590083

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
ETV6-ABL2 ETV6-ABL2 ETV6 12022903 0 1 ABL2 179102475 0 1 CCTGAAGAGCACGCCATGCCCATTGGGAGAATAGCAgATCACTTTGCCAGCTGTGTGGAGGATGGATTTGAG 10706884 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
ETV6-ABL2 ETV6-ABL2 1) SAM_PNT
1) SAM_PNT , Phage_lysozyme
- -ETV6 1) SAM_PNT
2) Ets
1) SAM_PNT , Phage_lysozyme
2) SRF-TF , Ank_2 , PAX , Ets
ABL2 1) SH3_1
2) SH2
3) Pkinase_Tyr
4) F_actin_bind
1) SH3_1 , Ank_2 , P53 , ubiquitin , Asp , PB1 , SH3_2 , F-protein , Pkinase_Tyr , Trypsin , Guanylate_kin , SH2 , p47_phox_C
2) C1_1 , PI3Ka , SH3_1 , Y_phosphatase , C2 , PI3_PI4_kinase , SH3_2 , fn3 , PAG , Pkinase_Tyr , SOCS_box , PI3K_C2 , SH2 , STAT_bind
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) Ets
2) SH_1
3) SH2
4) Pkinase_Tyr
5) F_actin_bind
1) SRF-TF , Ank_2 , PAX , Ets
2) SH3_1 , Ank_2 , P53 , ubiquitin , Asp , PB1 , SH3_2 , F-protein , Pkinase_Tyr , Trypsin , Guanylate_kin , SH2 , p47_phox_C
3) C1_1 , PI3Ka , SH3_1 , Y_phosphatase , C2 , PI3_PI4_kinase , SH3_2 , fn3 , PAG , Pkinase_Tyr , SOCS_box , PI3K_C2 , SH2 , STAT_bind
4) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
ETV6-ABL2 hsa-miR-140-3phsa-miR-103a-3phsa-miR-16-5phsa-miR-92a-3p hsa-miR-129-5phsa-miR-296-3phsa-miR-99b-5phsa-miR-92a-3p NGS

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
ETV6-ABL2 NM_001987.4 1) TRIM28_HUMAN
2) MITF_HUMAN
3) STAT1_HUMAN
4) RBL2_HUMAN
5) P53_HUMAN
6) RUNX1_HUMAN
7) PRDM14_HUMAN
8) ETS1_HUMAN
9) EGR1_HUMAN
10) GATA2_HUMAN
11) GATA3_HUMAN
12) SOX2_HUMAN
13) TAL1_HUMAN
14) CTCF_HUMAN
15) BRG1_HUMAN
16) HNF4A_HUMAN
17) FOXA1_HUMAN
18) CEBPA_HUMAN
19) CTCF_HUMAN
20) ESR1_HUMAN
21) SETDB1_HUMAN
22) SPI1_HUMAN
23) TRIM24_HUMAN
- 1) 17542650
2) 21258399
3) 19122651
4) 20385362
5) 21394211
6) 20019798
7) 20953172
8) 20019798
9) 20690147
10) 21808000
11) 21878914
12) 21211035
13) 21795385
14) 21795385
15) 19505939
16) 21646355
17) 21572391
18) 20219941
19) 20219941
20) 21235772
21) 21430779
22) 21241896
23) 21164480

TicDB

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The fusion gene pair ETV6--ABL2 information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
ETV6 ABL2 10706884 CCTGAAGAGCACGCCATGCCCATTGGGAGAATAGCAgATCACTTTGCCAGCTGTGTGGAGGATGGATTTGAG

TUMOR FUSION Gene Data Portal

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The fusion gene pair ETV6--ABL2 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair ETV6--ABL2 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair ETV6--ABL2 information is not available in ConjoinG Database.

1000Genome

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Fusion gene ETV6--ABL2 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene ETV6--ABL2 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene ETV6--ABL2 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene ETV6--ABL2 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene ETV6--ABL2 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair ETV6--ABL2 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene ETV6--ABL2 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene ETV6--ABL2 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene ETV6 is a known oncogene according to ONGENE database.


The tail gene ABL2 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene ETV6 is cancer associated according to Bushman Cancer Gene database.


The tail gene ABL2 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene ETV6 is proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene ABL2 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene ETV6--ABL2 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene ETV6--ABL2 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair ETV6--ABL2 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene ETV6--ABL2 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene ETV6--ABL2 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair ETV6--ABL2 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair ETV6--ABL2 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair ETV6--ABL2 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene ETV6--ABL2 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair ETV6--ABL2 information is not available in ChromothripsisDB database.