ERBB2--EGFR

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

 ERBB2 EGFR

COSMIC

The fusion gene pair ERBB2--EGFR information is not available in COSMIC database.

ChimerKB

 Top
The fusion gene pair ERBB2--EGFR information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

 Top
The fusion gene pair ERBB2--EGFR information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
ERBB2_EGFR- 18182111ovarian cancer FISH - EGFR/HER2-neu targeted therapies should be investigated prospectively and specifically in that subset of patients..
ERBB2_EGFR- 24199682non small cell lung cancer;lung cancer - - Crizotinib+erlotinib (reversible EGFR TKI) and crizotinib+afatinib (irreversible EGFR/ERBB2 TKI) were able to inhibit the growth of H3122 CR clones, confirming EGFR activation as a mechanism of resistance.
ERBB2_EGFR- 24835218adenocarcinoma - - Based on these results, a dual EGFR/ERBB2 inhibitor, afatinib, was chosen for treatment.
ERBB2_EGFR- 25603171- - - Here we took advantage of these conformational probes to reveal the existence of tethered EGFR in EGFR/ErbB2 predimers. /// Conformational nanobodies reveal tethered epidermal growth factor receptor involved in EGFR/ErbB2 predimers..

ChimerSEQ

 Top
The fusion gene pair ERBB2--EGFR information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

 Top
The fusion gene pair ERBB2--EGFR information is not available in CHITARS database.

FARE-CAFE

 		Top
The fusion gene pair ERBB2--EGFR information is not available in FARE-CAFE.

TicDB

 		Top
The fusion gene pair ERBB2--EGFR information is not available in TicDB.

TUMOR FUSION Gene Data Portal

 		Top
The fusion gene pair ERBB2--EGFR information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

 		Top
The fusion gene pair ERBB2--EGFR information is not available in FusionCancer Database.

ConjoinG

 		Top
The fusion gene pair ERBB2--EGFR information is not available in ConjoinG Database.

1000Genome

 		Top
Fusion gene ERBB2--EGFR has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

 		Top
Fusion gene ERBB2--EGFR is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

 		Top
Fusion gene ERBB2--EGFR is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

 		Top
Fusion gene ERBB2--EGFR is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

 		Top
Fusion gene ERBB2--EGFR was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

 		Top
The fusion gene pair ERBB2--EGFR information is not available in Babiceanu_Dataset.

Banned_Dataset

 		Top
Fusion gene ERBB2--EGFR is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

 		Top
Fusion gene ERBB2--EGFR has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

 		Top
The head gene ERBB2 is a known oncogene according to ONGENE database.


The tail gene EGFR is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

 		Top
The head gene ERBB2 is cancer associated according to Bushman Cancer Gene database.


The tail gene EGFR is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

 		Top
The head gene ERBB2 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene EGFR is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

 		Top
Fusion gene ERBB2--EGFR is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

 		Top
Fusion gene ERBB2--EGFR is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

 		Top
The fusion gene pair ERBB2--EGFR information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

 		Top
Fusion gene ERBB2--EGFR is not found in pancreatic tumor dataset, published here.

GTEx

 		Top
Fusion gene ERBB2--EGFR has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

 		Top
The fusion gene pair ERBB2--EGFR information is not available in Klijn Dataset.

Fimereli_Dataset

 		Top
The fusion gene pair ERBB2--EGFR information is not found in Fimereli_Dataset.

Literature

 Top
The fusion gene pair ERBB2--EGFR information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

 		Top
Fusion gene ERBB2--EGFR is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

 		Top
The fusion gene pair ERBB2--EGFR information is not available in ChromothripsisDB database.