DCTN1--ALK

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

 DCTN1 ALK

COSMIC

The fusion gene pair DCTN1--ALK information is available in COSMIC database.

Link
DCTN1--ALK

ChimerKB

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The fusion gene pair DCTN1--ALK information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
DCTN1_ALK-/3514/ -/4080/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
DCTN1_ALK-/2172/ -/4080/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
DCTN1_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 22658521 Oncogene; Cosmic_nonrecurrent
DCTN1_ALK-/-/ -/-/ - hg19 - - 24445538 Oncogene; Cosmic_nonrecurrent

ChimerPUB

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The fusion gene pair DCTN1--ALK information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
DCTN1_ALK- 25813404non small cell lung cancer;lung cancer FISH;PCR - furthermore, the DCTN1/ALK fusion was also found in another NSCLC sample with unbalanced 5'/3'-end ALK expression, indicating a recurrent nature of this translocation.
DCTN1_ALK- 26062823smooth muscle tumor - - Immunostains showed diffuse positivity for ALK1 expression and comprehensive genomic profiling identified an in frame DCTN1-ALK gene fusion. /// "To our knowledge, this case represents the first report of clinical response to targeted therapy in a tumor harboring a DCTN1-ALK fusion protein. "

ChimerSEQ

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The fusion gene pair DCTN1--ALK information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
DCTN1_ALKchr2/74596332/ chr2/29445266/ 2p13.1 2p23.2 Exonic hg19 - Intra-chr inflammatory myofibroblastic tumor;myofibroblastic sarcoma HQ993071 Oncogene; ChiTaRs

ChiTaRS 2.1

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The fusion gene pair DCTN1--ALK information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human HQ993071DCTN1--ALK DCTN12 74595911 74596332 - 1 205 100 ALK2 29445266 29446397 - 203 492 100

FARE-CAFE

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The fusion gene pair DCTN1--ALK information is not available in FARE-CAFE.

TicDB

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The fusion gene pair DCTN1--ALK information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair DCTN1--ALK information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair DCTN1--ALK information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair DCTN1--ALK information is not available in ConjoinG Database.

1000Genome

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Fusion gene DCTN1--ALK has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene DCTN1--ALK is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene DCTN1--ALK is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene DCTN1--ALK is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene DCTN1--ALK was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair DCTN1--ALK information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene DCTN1--ALK is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene DCTN1--ALK has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene DCTN1 is not a known oncogene according to ONGENE database.


The tail gene ALK is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene DCTN1 is not cancer associated according to Bushman Cancer Gene database.


The tail gene ALK is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene DCTN1 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene ALK is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene DCTN1--ALK is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene DCTN1--ALK is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair DCTN1--ALK information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene DCTN1--ALK is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene DCTN1--ALK has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair DCTN1--ALK information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair DCTN1--ALK information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair DCTN1--ALK information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene DCTN1--ALK is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair DCTN1--ALK information is not available in ChromothripsisDB database.