CLTC--ALK

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

CLTC ALK

COSMIC

The fusion gene pair CLTC--ALK information is available in COSMIC database.

Link
CLTC--ALK

ChimerKB

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The fusion gene pair CLTC--ALK information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
CLTC_ALK-/5177/ -/4080/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
CLTC_ALK-/5177+2010/ -/4080-48/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
CLTC_ALK-/5101/ -/4080-120/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
CLTC_ALK-/-/ -/-/ - hg19 lymphoid neoplasm - 10807789 Oncogene; Cosmic_nonrecurrent
CLTC_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 11485898 Oncogene; Cosmic_nonrecurrent
CLTC_ALK-/-/ -/-/ - hg19 lymphoid neoplasm - 12112524 Oncogene; Cosmic_nonrecurrent
CLTC_ALK-/-/ -/-/ - hg19 lymphoid neoplasm - 12920229 Oncogene; Cosmic_nonrecurrent
CLTC_ALK-/-/ -/-/ - hg19 lymphoid neoplasm - 12763927 Oncogene; Cosmic_nonrecurrent
CLTC_ALK-/-/ -/-/ - hg19 lymphoid neoplasm - 15852431 Oncogene; Cosmic_nonrecurrent
CLTC_ALK-/-/ -/-/ - hg19 lymphoid neoplasm - 15492998 Oncogene; Cosmic_nonrecurrent
CLTC_ALK-/-/ -/-/ - hg19 lymphoid neoplasm - 16107887 Oncogene; Cosmic_nonrecurrent
CLTC_ALK-/-/ -/-/ - hg19 lymphoid neoplasm - 16086416 Oncogene; Cosmic_nonrecurrent
CLTC_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 16984614 Oncogene; Cosmic_nonrecurrent
CLTC_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 17656252 Oncogene; Cosmic_nonrecurrent
CLTC_ALK-/-/ -/-/ - hg19 lymphoid neoplasm - 12750159 Oncogene; Cosmic_nonrecurrent
CLTC_ALK-/-/ -/-/ - hg19 lymphoid neoplasm - 18755494 Oncogene; Cosmic_nonrecurrent
CLTC_ALK-/0/ -/0/ Exonic hg18 - - - Oncogene; TICdb
CLTC_ALK-/2008/ -/1882/ Exonic hg18 - - - Oncogene; TICdb

ChimerPUB

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The fusion gene pair CLTC--ALK information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
CLTC_ALK- 24583837- FISH - Spindle tumor cells expressed ALK with a cytoplasmic granular distribution, the CLTC-ALK fusion gene was demonstrated by reverse-transcriptase polymerase chain reaction analysis, and break-apart fluorescence in situ hybridization (FISH) probes for the ALK gene showed a pathological pattern (single red signal associated with 1/2 normal fused signals) highly suggestive for combined gene fusion and deletion.
CLTC_ALKinv(2)(p23q12) / del(2) / 1p11.2 / t(2;17)(p23;q23) / 17656252- FISH - In addition, we identified the ALK fusion partner in a previously reported IMT with t(2;17)(p23;q23) as CLTC, a gene reported to be involved in four other IMTs, and showed that the breakpoint involved a novel ALK-CLTC fusion.
CLTC_ALK- 23588372B cell lymphoma;lymphoma FISH - The gene fusion product and the transcription factor STAT3 are both phosphorylated, and thereby the pathogenetic mechanism of this case shows important analogies with that of NPM-ALK and CLTC-ALK lymphomas, in which STAT3 plays a central role in the lymphomagenesis. /// " ALK-positive large B-cell lymphomas usually harbor clathrin (CLTC)-ALK rearrangement or, more rarely, nucleophosmin (NPM)-ALK fusion gene. "
CLTC_ALKt(2;17)(p23;q23) / 12750159anaplastic large cell lymphoma;B cell lymphoma;lymphoma FISH - Fluorescent in situ hybridization (FISH) and molecular studies led to the detection of a CLTC-ALK rearrangement in all 3 cases, without any evidence of full-length ALK receptor expression. /// "Although a similar CLTC-ALK aberration was previously identified in ALK-positive T-/null cell ALCL and inflammatory myofibroblastic tumor, its association with ALK-positive LBCL seems to be specific and intriguing.. " /// "Although a similar CLTC-ALK aberration was previously identified in ALK-positive T-/null cell ALCL and inflammatory myofibroblastic tumor, its association with ALK-positive LBCL seems to be specific and intriguing.." /// ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma..
CLTC_ALKt(2;17)(p23;q23) / 19521280B cell lymphoma;lymphoma FISH - While reports show detection of the unique CLTC-ALK fusion by either reverse transcription-polymerase chain reaction or fluorescence in situ hybridization, our case represents the second case in the literature to detect the t(2;17)(p23;q23) translocation by multiplex karyotyping (multiplex fluorescence in situ hybridization) and the usefulness of this technique to detect hidden translocations not seen by G-banding.
CLTC_ALK- 15852431non Hodgkin Lymphoma FISH - The clathrin gene (CLTC)-ALK fusion underlying aberrant expression of ALK in the present case was demonstrated by interphase fluorescence in situ hybridization (FISH) using break-apart rearrangement probes for ALK and CLTC.
CLTC_ALKt(2;17)(p23;q23) / / 12763927B cell lymphoma;anaplastic large cell lymphoma;lymphoma FISH - Moreover, these results demonstrate the presence of CLTC-ALK fusions in these tumors and extend the list of diseases associated with this genetic abnormality to include classical T-cell or null ALCL, ALK+ DLBCL, and inflammatory myofibroblastic tumors..
CLTC_ALKt(2;5) / 15921012anaplastic large cell lymphoma;B cell lymphoma;lymphoma FISH - Genetic studies showed that the majority of ALK+DLBCL cases are characterized by the clathrin (CLTC)-ALK fusion and in a few cases the NPM-ALK rearrangement has been found..
CLTC_ALK- 12920229B cell lymphoma;lymphoma FISH - As 2;17 translocation resulting in the fusion of clathrin heavy chain (CLTC) gene with ALK was previously reported in inflammatory myofibroblastic tumor, we performed reverse transcriptase-polymerase chain reaction and demonstrated that the lymphoma cells contained CLTC-ALK fusion transcript. /// "As 2;17 translocation resulting in the fusion of clathrin heavy chain (CLTC) gene with ALK was previously reported in inflammatory myofibroblastic tumor, we performed reverse transcriptase-polymerase chain reaction and demonstrated that the lymphoma cells contained CLTC-ALK fusion transcript."
CLTC_ALK- 21855232plasma cell myeloma FISH;PCR;RT-PCR - ALK-positive extramedullary plasmacytoma with expression of the CLTC-ALK fusion transcript.. /// Both RT-PCR and genomic DNA-PCR confirmed the CLTC-ALK fusion. /// Both RT-PCR and genomic DNA-PCR confirmed the CLTC-ALK fusion.
CLTC_ALKt(2;5)(p23;q35) / t(1;2)(q25;p23) / t(2;3)(p23;q21) / t(2;17)(p23;q23) / inv(2)(p23q35) / 15208656anaplastic large cell lymphoma;lymphoma - - Recent studies demonstrated that ALK may also be involved in variant translocations, namely, t(1;2)(q25;p23), t(2;3)(p23;q21), t(2;17)(p23;q23) and inv(2)(p23q35), which create the TPM3-ALK, TFG-ALK5, CLTC-ALK, and ATIC-ALK fusion genes, respectively. /// "We stably transfected the cDNAs coding for NPM-ALK, TPM3-ALK, TFG-ALK, CLTC-ALK or ATIC-ALK into nonmalignant NIH3T3 cells." /// "We stably transfected the cDNAs coding for NPM-ALK, TPM3-ALK, TFG-ALK, CLTC-ALK or ATIC-ALK into nonmalignant NIH3T3 cells. "
CLTC_ALKt(2;17;8)(p23;q23;p23) / 24142740acute myeloid leukemia;myeloid leukemia;leukemia - - The peripheral blood leukocytes revealed the t(2;17;8)(p23;q23;p23) translocation and a CLTC-ALK fusion gene, which have never been reported in BPDCN or in any myeloid malignancies thus far. /// "Neonatal blood spots on the patient's Guthrie card were analyzed for the presence of the CLTC-ALK fusion gene, identifying the in utero origin of the leukemic cell. " /// "This is the first report of the CLTC-ALK fusion gene being associated with a myeloid malignancy, which may give us an important clue to the origin of this rare neoplasm.. " /// "Although the leukemic cells were positive for CD4, CD56, CD123, and CD303, indicating a plasmacytoid dendritic cell phenotype, detailed analysis of the lineage distribution of CLTC-ALK revealed that part of monocytes, neutrophils, and T cells possessed the fusion gene and were involved in the leukemic clone." /// "Although the leukemic cells were positive for CD4, CD56, CD123, and CD303, indicating a plasmacytoid dendritic cell phenotype, detailed analysis of the lineage distribution of CLTC-ALK revealed that part of monocytes, neutrophils, and T cells possessed the fusion gene and were involved in the leukemic clone. " /// These results indicated that leukemic cells with CLTC-ALK originated in a multipotent hematopoietic progenitor in utero. /// CLTC-ALK fusion as a primary event in congenital blastic plasmacytoid dendritic cell neoplasm..
CLTC_ALKt(2;5)(p23;q35) / t(2;17)(p23;q25) / t(2;11;2)(p23;p15;q31) / 12112524anaplastic large cell lymphoma;lymphoma - - Our study led to the detection of the CLTC-ALK fusion in an ALCL case and to the identification of two novel fusion partners of ALK: ALO17 (KIAA1618), a gene with unknown function, which was fused to ALK in an ALCL case with a t(2;17)(p23;q25), and CARS, encoding the cysteinyl-tRNA synthetase, which was fused to ALK in an IMT case with a t(2;11;2)(p23;p15;q31). /// "While most of the ALK-positive ALCL (ALKomas) are characterized by the presence of the NPM-ALK fusion protein, the product of the t(2;5)(p23;q35), 10-20% of ALKomas contain variant ALK fusions, including ATIC-ALK, TFG-ALK, CLTC-ALK (previously designated CLTCL-ALK), TMP3-ALK, and MSN-ALK. " /// "While most of the ALK-positive ALCL (ALKomas) are characterized by the presence of the NPM-ALK fusion protein, the product of the t(2;5)(p23;q35), 10-20% of ALKomas contain variant ALK fusions, including ATIC-ALK, TFG-ALK, CLTC-ALK (previously designated CLTCL-ALK), TMP3-ALK, and MSN-ALK."
CLTC_ALKt(2;17)(p23;q23) / 22474449B cell lymphoma;lymphoma - - The most common gene rearrangement is between clathrin and ALK (t(2;17)(p23;q23)), resulting in the CLTC-ALK chimeric protein, although other fusions have been described.
CLTC_ALKt(2;17) / 21494621B cell lymphoma - - Most of them feature a t(2;17) encoding a clathrin (CLTC)-ALK fusion protein. /// These data indicate a role of CLTC-ALK in the maintenance of the malignant phenotype thereby providing a rationale therapeutic target for these otherwise refractory tumors.. /// We established and characterized the first CLTC-ALK positive DLBCL cell line (LM1).
CLTC_ALKt(2;17)(p23;q23) / 15492998B cell lymphoma;lymphoma PCR;RT-PCR - This report describes a primary gastric ALK-positive B-lineage lymphoma in which a clathrin (CLTC)-ALK fusion was identified by RT-PCR and direct sequencing of the breakpoint.
CLTC_ALK- 21134980B cell lymphoma;lymphoma - - We examined an ALK-positive large B-cell lymphoma case showing an anti-ALK immunohistochemistry pattern distinct from those of 2 known ALK fusions, CLTC-ALK and NPM-ALK, for the presence of a novel ALK fusion.
CLTC_ALK- 18458503B cell lymphoma;lymphoma ISH - [Cytomorphology and molecular characterization of CLTC-ALK rearrangement in 2 cases of ALK-positive diffuse large B-cell lymphoma with extensive bone marrow involvement].. /// Fluorescence in situ hybridization and molecular studies on the bone marrow aspirate specimens led to the detection of a clathrin (CLTC)/ALK rearrangement.

ChimerSEQ

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The fusion gene pair CLTC--ALK information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair CLTC--ALK information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair CLTC--ALK information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
CLTC-ALK Inflammatory myofibroblastic tumor FISH,G-Banding,RT-PCR [46,XX,t(2;17)(p23;q23),add(16)(q24)] PubMed:11485898

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
CLTC-ALK CLTC-ALK-Isoform1 CLTC 57768072 0 1 ALK 29446330 0 1 AAAGAAGAAGAACAAGCTACAGAGACACAACCCATTGTTTATgTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGAGCCCTGAGTACAAG 10807789 _
CLTC-ALK CLTC-ALK-Isoform2 CLTC _ _ 1 ALK 29446369 0 1 CAACCCATTGTTTATgTGTACCGCCGGAAGCACCAGGAGCTG 11485898 _
CLTC-ALK CLTC-ALK-Isoform3 CLTC 57768072 0 1 ALK 29446372 0 1 GAGACACAACCCATTGTTTATgTGTACCGCCGGAAGCACCAGGAG 12112524 _
CLTC-ALK CLTC-ALK-Isoform4 CLTC 57770082 0 1 ALK 29446375 0 1 ACACAACCCATTGTTTATGATGGGGTCTCGTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAACCTtCAAGGGCCAGGCTGCCAGGCCATGTTGCAGCTGACCACCCACCTGCAGTGTACCGCCGGAAGCACCAG 12750159 _
CLTC-ALK CLTC-ALK-Isoform5 CLTC 57770038 0 1 ALK _ 0 _ ATGTCTTTTTTTTTCCCCAAgATGGGGTCTCGTCTGTCAC 12750159 _
CLTC-ALK CLTC-ALK-Isoform6 CLTC _ _ 1 ALK 29446374 0 1 ACACAACCCATTGTTTATgTGTACCGCCGGAAGCACCAGG 12920229 _
CLTC-ALK CLTC-ALK-Isoform7 CLTC _ _ 1 ALK 29446371 0 1 GCTCCTGGTGCTTCCGGCGGTAGaCATAAACAATGGGTTGTGT 15492998 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
CLTC-ALK CLTC-ALK-Isoform1 1) Clathrin_propel
2) Clathrin-link
3) Clathrin_H_link
4) Clathrin
1) Clathrin_propel , Clathrin-link , Arrestin_C
2) Clathrin_propel , Clathrin_H_link
3) Clathrin-link
4) Clathrin , Clathrin_lg_ch
1) MAM
2) Gly_rich
1) ig , Astacin , MATH
CLTC 1) Clathrin_propel
2) Clathrin-link
3) Clathrin_H_link
4) Clathrin
1) Clathrin_propel , Clathrin-link , Arrestin_C
2) Clathrin_propel , Clathrin_H_link
3) Clathrin-link
4) Clathrin , Clathrin_lg_ch
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
- -
CLTC-ALK CLTC-ALK-Isoform2 - - 1) MAM
2) Gly_rich
1) ig , Astacin , MATH
CLTC 1) Clathrin_propel
2) Clathrin-link
3) Clathrin_H_link
4) Clathrin
1) Clathrin_propel , Clathrin-link , Arrestin_C
2) Clathrin_propel , Clathrin_H_link
3) Clathrin-link
4) Clathrin , Clathrin_lg_ch
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) Clathrin_propel
2) Clathrin-link
3) Clathrin_H_link
4) Clathrin
1) Clathrin_propel , Clathrin-link , Arrestin_C
2) Clathrin_propel , Clathrin_H_link
3) Clathrin-link
4) Clathrin , Clathrin_lg_ch
CLTC-ALK CLTC-ALK-Isoform3 1) Clathrin_propel
2) Clathrin-link
3) Clathrin_H_link
4) Clathrin
1) Clathrin_propel , Clathrin-link , Arrestin_C
2) Clathrin_propel , Clathrin_H_link
3) Clathrin-link
4) Clathrin , Clathrin_lg_ch
1) MAM
2) Gly_rich
1) ig , Astacin , MATH
CLTC 1) Clathrin_propel
2) Clathrin-link
3) Clathrin_H_link
4) Clathrin
1) Clathrin_propel , Clathrin-link , Arrestin_C
2) Clathrin_propel , Clathrin_H_link
3) Clathrin-link
4) Clathrin , Clathrin_lg_ch
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) MAM
1) ig , Astacin , MATH
CLTC-ALK CLTC-ALK-Isoform4 1) Clathrin_propel
2) Clathrin-link
3) Clathrin_H_link
4) Clathrin
1) Clathrin_propel , Clathrin-link , Arrestin_C
2) Clathrin_propel , Clathrin_H_link
3) Clathrin-link
4) Clathrin , Clathrin_lg_ch
1) MAM
2) Gly_rich
1) ig , Astacin , MATH
CLTC 1) Clathrin_propel
2) Clathrin-link
3) Clathrin_H_link
4) Clathrin
1) Clathrin_propel , Clathrin-link , Arrestin_C
2) Clathrin_propel , Clathrin_H_link
3) Clathrin-link
4) Clathrin , Clathrin_lg_ch
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) MAM
1) ig , Astacin , MATH
CLTC-ALK CLTC-ALK-Isoform5 1) Clathrin_propel
2) Clathrin-link
3) Clathrin_H_link
4) Clathrin
1) Clathrin_propel , Clathrin-link , Arrestin_C
2) Clathrin_propel , Clathrin_H_link
3) Clathrin-link
4) Clathrin , Clathrin_lg_ch
- -CLTC 1) Clathrin_propel
2) Clathrin-link
3) Clathrin_H_link
4) Clathrin
1) Clathrin_propel , Clathrin-link , Arrestin_C
2) Clathrin_propel , Clathrin_H_link
3) Clathrin-link
4) Clathrin , Clathrin_lg_ch
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
- -
CLTC-ALK CLTC-ALK-Isoform6 - - 1) MAM
2) Gly_rich
1) ig , Astacin , MATH
CLTC 1) Clathrin_propel
2) Clathrin-link
3) Clathrin_H_link
4) Clathrin
1) Clathrin_propel , Clathrin-link , Arrestin_C
2) Clathrin_propel , Clathrin_H_link
3) Clathrin-link
4) Clathrin , Clathrin_lg_ch
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) Clathrin_propel
2) Clathrin-link
3) Clathrin_H_link
4) Clathrin
1) Clathrin_propel , Clathrin-link , Arrestin_C
2) Clathrin_propel , Clathrin_H_link
3) Clathrin-link
4) Clathrin , Clathrin_lg_ch
CLTC-ALK CLTC-ALK-Isoform7 - - 1) MAM
2) Gly_rich
1) ig , Astacin , MATH
CLTC 1) Clathrin_propel
2) Clathrin-link
3) Clathrin_H_link
4) Clathrin
1) Clathrin_propel , Clathrin-link , Arrestin_C
2) Clathrin_propel , Clathrin_H_link
3) Clathrin-link
4) Clathrin , Clathrin_lg_ch
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) Clathrin_propel
2) Clathrin-link
3) Clathrin_H_link
4) Clathrin
1) Clathrin_propel , Clathrin-link , Arrestin_C
2) Clathrin_propel , Clathrin_H_link
3) Clathrin-link
4) Clathrin , Clathrin_lg_ch

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
CLTC-ALK hsa-miR-132-3p hsa-miR-155-5phsa-miR-1hsa-miR-99a-3phsa-miR-615-3phsa-miR-503-5phsa-miR-484hsa-miR-106b-5phsa-miR-92a-3phsa-miR-16-5phsa-let-7e-5phsa-miR-4326 Microarray

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
CLTC-ALK NM_001288653.1 - 1) TRIM28_HUMAN
2) MITF_HUMAN
3) STAT1_HUMAN
4) RBL2_HUMAN
5) P53_HUMAN
6) RUNX1_HUMAN
7) PRDM14_HUMAN
8) ESTROGEN RECEPTOR ALPHA_HUMAN
9) EGR1_HUMAN
10) FOS_HUMAN
11) GATA3_HUMAN
12) E2F1_HUMAN
13) SOX2_HUMAN
14) CTCF_HUMAN
15) BRG1_HUMAN
16) HNF4A_HUMAN
17) TFAP2C_HUMAN
18) FOXA1_HUMAN
19) ESR1_HUMAN
20) NR1H3_HUMAN
21) SETDB1_HUMAN
-

TicDB

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The fusion gene pair CLTC--ALK information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
CLTC ALK 10807789 AAAGAAGAAGAACAAGCTACAGAGACACAACCCATTGTTTATgTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGAGCCCTGAGTACAAG
CLTC ALK 11485898 CAACCCATTGTTTATgTGTACCGCCGGAAGCACCAGGAGCTG
CLTC ALK 12112524 GAGACACAACCCATTGTTTATgTGTACCGCCGGAAGCACCAGGAG
CLTC ALK 12750159 ACACAACCCATTGTTTATGATGGGGTCTCGTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAACCTtCAAGGGCCAGGCTGCCAGGCCATGTTGCAGCTGACCACCCACCTGCAGTGTACCGCCGGAAGCACCAG
CLTC ALK 12750159 ATGTCTTTTTTTTTCCCCAAgATGGGGTCTCGTCTGTCAC
CLTC ALK 12920229 ACACAACCCATTGTTTATgTGTACCGCCGGAAGCACCAGG
CLTC ALK 15492998 GCTCCTGGTGCTTCCGGCGGTAGaCATAAACAATGGGTTGTGT

TUMOR FUSION Gene Data Portal

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The fusion gene pair CLTC--ALK information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair CLTC--ALK information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair CLTC--ALK information is not available in ConjoinG Database.

1000Genome

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Fusion gene CLTC--ALK has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene CLTC--ALK is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene CLTC--ALK is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene CLTC--ALK is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene CLTC--ALK was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair CLTC--ALK information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene CLTC--ALK is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene CLTC--ALK has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene CLTC is not a known oncogene according to ONGENE database.


The tail gene ALK is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene CLTC is cancer associated according to Bushman Cancer Gene database.


The tail gene ALK is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene CLTC is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene ALK is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene CLTC--ALK is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene CLTC--ALK is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair CLTC--ALK information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene CLTC--ALK is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene CLTC--ALK has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair CLTC--ALK information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair CLTC--ALK information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair CLTC--ALK is found in known fusion genelist compiled from literature.

FusionGeneArticleLink
CLTC--ALKThe pathology of soft tissue sarcomas (Marta Sbaraglia and Angelo P. Dei Tos; ONCOLOGY IMAGING)https://doi.org/10.1007/s11547-018-0882-7

Cortex_Dataset

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Fusion gene CLTC--ALK is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair CLTC--ALK information is not available in ChromothripsisDB database.