CDKN2B--CDKN2A

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

CDKN2B CDKN2A

COSMIC

The fusion gene pair CDKN2B--CDKN2A information is not available in COSMIC database.

ChimerKB

Top
The fusion gene pair CDKN2B--CDKN2A information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

Top
The fusion gene pair CDKN2B--CDKN2A information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
CDKN2B_CDKN2A9p21.3 / 12p13.2 / 7p12.2 / 21900200- FISH - Complete or partial chromosomal losses largely outnumbered the gains, with common deleted regions involving 9p21.3 (CDKN2A/CDKN2B), 13q13.1-q14.3 (RB1), 12p13.2-p13.1 (CDKN1B), 13q11-q12 (LATS2), and 7p12.2 (IKZF1) regions. /// CDKN2A/CDKN2B deletion was confirmed by FISH. /// "We suggest that, in the absence of reliable parameters for predicting prognosis in BPDCN other than age, tumor stage, and/or clinical presentation, simple methods, such as FISH for CDKN2A/CDKN2B, could help to identify the most aggressive cases.. "
CDKN2B_CDKN2A- 10644453melanoma FISH - Double-color fiber FISH mapping confirmed the location of PLAA centromeric to D9S171 and CDKN2A/CDKN2B. /// Yeast artificial chromosome (YAC) mapping localized PLAA proximal to the CDKN2A/CDKN2B genes and to a region flanked by D9S171 and INFA commonly deleted in many neoplasms.
CDKN2B_CDKN2A7p15.2 / 18332873adenoid cystic carcinoma FISH - The minimal common regions of deletions contained the CDKN2A/CDKN2B, TP53, and LIMA1 tumor suppressor genes.
CDKN2B_CDKN2A9p21.3 / 21713760glioblastoma multiforme - - To obtain a comprehensive view of these events, we leveraged the wide-spectrum GBM data available from The Cancer Genome Atlas project and performed an integrated analysis by systematically evaluating 9p21.3-related germline single-nucleotide polymorphisms, somatic copy number alterations (CNAs), DNA methylation, and microRNAs (miRNAs) with regard to CDKN2A/CDKN2B expression and patient prognosis in GBM. /// "A variety of germline and somatic, genetic and epigenetic alterations at 9p21.3, which encode CDKN2A/CDKN2B tumor suppressor genes, have been isolatedly reported to be associated with GBM risk and prognosis. "
CDKN2B_CDKN2A9p21.3 / 19887491gastrointestinal stromal tumor - - MTAP and/or CDKN2A/CDKN2B at 9p21.3 were deleted in one intermediate-risk (11%) and seven high-risk (70%) GISTs with two cases homozygously codeleted at both loci.
CDKN2B_CDKN2Adel(3) / del(9) / t(9;12) / t(12;19) / t(17;19) / t(10;20) / 9p24.3 / 10p15.3 / 22002331chordoma - - MUG-Chor1 is karyotypically, <2n>43-47,XX,del(3)(q1?)[11], +7,del(9)(p1?),der(9;15)(q10;q10),-10,+der(12)t(9;12)(p2?;q1?),der (12)t(12;19)(p;p)t(17;19)(q;q),-15,der(17;21)(q10;q10),der(20)t(10;20) (q25?26?;q11?12?),-21,-22[20]/idemx2[5] and displays known, chordoma-typical genetic changes, such as chromosomal gains at T/brachyury locus (6q27), losses at 9p24.3-p13.1 (includes the CDKN2a/CDKN2b locus), 10p15.3-q23.32 (includes the PTEN locus) and losses of 10q25.2 (includes the PDCD4 locus).
CDKN2B_CDKN2A5p15.33 / 9p21.3 / 20847058- - - Genome-wide association studies have recently identified single-nucleotide polymorphisms (SNP) in five loci at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A/CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1) to be associated with glioma risk.
CDKN2B_CDKN2A9p21.3 / 20364137- - - OR = 1.28, P = 1.3 x 10(-12)) and CDKN2A-CDKN2B (9p21.3.
CDKN2B_CDKN2A5p15.33 / 9p21.3 / 7p11.2 / 21825990- - - Seven independent chromosomal loci have robustly been associated with glioma risk: 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1), and two loci at 7p11.2 (rs11979158 and rs2252586, EGFR).
CDKN2B_CDKN2A5p15.33 / 9p21.3 / 19578367primary brain tumor - - P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B.
CDKN2B_CDKN2A5p15.33 / 9p21.3 / 20462933asthma - - Genome-wide association data have identified common genetic variants at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 11q23.3 (rs498872, PHLDB1), and 20q13.33 (rs6010620, RTEL1) as determinants of glioma risk.
CDKN2B_CDKN2A5p15.33 / 9p21.3 / 23115063- - - In analyses including glioma cases with a family history of brain tumours (n = 104) and control subjects free of glioma at baseline, three of seven SNPs were associated with glioma risk: rs2736100 (5p15.33, TERT), rs4977756 (9p21.3, CDKN2A-CDKN2B) and rs6010620 (20q13.33, RTEL1).
CDKN2B_CDKN2At(11;14)(q13;q32) / 16258956mantle cell lymphoma;mantle cell lymphoma;lymphoma PCR - In addition, alterations of other cell-cycle-regulating signal pathways (CDKN2B/CDKN2A-CCND1 and ARF-MDM2-TP53) are frequently observed.
CDKN2B_CDKN2At(1;19)(q10;p10) / 22789312pilocytic astrocytoma - - Single nucleotide polymorphisms in TERT,CCDC26, CDKN2A/CDKN2B, RTEL, EGFR and PHLDB1 confer an inherited susceptibility to glial tumors..
CDKN2B_CDKN2A1p31.1 / 26089329- - - Four of 7 previously reported ischemic stroke loci (PITX2, HDAC9, CDKN2A/CDKN2B, and ZFHX3) were nominally associated (P<0.05) with stroke in COMPASS.
CDKN2B_CDKN2A9p21.3 / 23101500neurofibroma - - ANRIL directly binds to the SUZ12 protein, an essential component of polycomb repressive complex 2, and is required for SUZ12 occupancy of the CDKN2A/CDKN2B tumour suppressor genes as well as for their epigenetic silencing.
CDKN2B_CDKN2A1p36.3 / 5p15.3 / 21281820mesothelioma - - Alteration of the 9p21 human region, often by biallelic deletion, was the most frequent alteration in both species, in agreement with the CDKN2A/CDKN2B locus deletion in human disease and murine models.
CDKN2B_CDKN2A- 18237450- PCR - Homozygous deletions were identified at 10 different genomic locations, most frequently affecting CDKN2A/CDKN2B in 9p21 (32%).
CDKN2B_CDKN2A- 19643034sarcoma PCR - Microsatellite markers on a paired tumour and blood DNA pointed to loss of heterozygosity on chromosome 11 in the CDKN2B-CDKN2A tumour suppressor gene cluster region.
CDKN2B_CDKN2A9p21.3 / 19214202aggressive periodontitis - - The two associated linkage disequilibrium regions map to the sequence of the large antisense noncoding RNA ANRIL, which partly overlaps regulatory and coding sequences of CDKN2A/CDKN2B.
CDKN2B_CDKN2A- 21889780astrocytoma;neurofibroma;tuberous sclerosis - - TERT, CCDC26, PHLDB1, RTEL1 and CDKN2A/CDKN2B).

ChimerSEQ

Top
The fusion gene pair CDKN2B--CDKN2A information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

Top
The fusion gene pair CDKN2B--CDKN2A information is not available in CHITARS database.

FARE-CAFE

Top
The fusion gene pair CDKN2B--CDKN2A information is not available in FARE-CAFE.

TicDB

Top
The fusion gene pair CDKN2B--CDKN2A information is not available in TicDB.

TUMOR FUSION Gene Data Portal

Top
The fusion gene pair CDKN2B--CDKN2A information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

Top
The fusion gene pair CDKN2B--CDKN2A information is not available in FusionCancer Database.

ConjoinG

Top
The fusion gene pair CDKN2B--CDKN2A information is not available in ConjoinG Database.

1000Genome

Top
Fusion gene CDKN2B--CDKN2A has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

Top
Fusion gene CDKN2B--CDKN2A is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

Top
Fusion gene CDKN2B--CDKN2A is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

Top
Fusion gene CDKN2B--CDKN2A is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

Top
Fusion gene CDKN2B--CDKN2A was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

Top
The fusion gene pair CDKN2B--CDKN2A information is not available in Babiceanu_Dataset.

Banned_Dataset

Top
Fusion gene CDKN2B--CDKN2A is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

Top
Fusion gene CDKN2B--CDKN2A has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

Top
The head gene CDKN2B is not a known oncogene according to ONGENE database.
The tail gene CDKN2A is not a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

Top
The head gene CDKN2B is cancer associated according to Bushman Cancer Gene database.


The tail gene CDKN2A is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

Top
The head gene CDKN2B is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene CDKN2A is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

Top
Fusion gene CDKN2B--CDKN2A is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

Top
Fusion gene CDKN2B--CDKN2A is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

Top
The fusion gene pair CDKN2B--CDKN2A information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

Top
Fusion gene CDKN2B--CDKN2A is not found in pancreatic tumor dataset, published here.

GTEx

Top
Fusion gene CDKN2B--CDKN2A has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

Top
The fusion gene pair CDKN2B--CDKN2A information is not available in Klijn Dataset.

Fimereli_Dataset

Top
The fusion gene pair CDKN2B--CDKN2A information is not found in Fimereli_Dataset.

Literature

Top
The fusion gene pair CDKN2B--CDKN2A information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

Top
Fusion gene CDKN2B--CDKN2A is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

Top
The fusion gene pair CDKN2B--CDKN2A information is not available in ChromothripsisDB database.