CDH11--USP6

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

CDH11 USP6

COSMIC

The fusion gene pair CDH11--USP6 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair CDH11--USP6 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
CDH11_USP6-/319/ -/1545/ Exonic hg19 - - - - Cosmic_recurrent
CDH11_USP6-/319/ -/1699/ Exonic hg19 - - - - Cosmic_recurrent
CDH11_USP6-/444/ -/1-3177/ Exonic hg19 - - - - Cosmic_recurrent
CDH11_USP6-/444/ -/1699/ Exonic hg19 - - - - Cosmic_recurrent
CDH11_USP6-/444/ -/1545/ Exonic hg19 - - - - Cosmic_recurrent
CDH11_USP6-/-/ -/-/ - hg19 - - 15026324 - Cosmic_nonrecurrent
CDH11_USP6-/-/ -/-/ - hg19 - - 15509545 - Cosmic_nonrecurrent
CDH11_USP6-/0/ -/1545/ Exonic hg18 - - - - TICdb
CDH11_USP6-/0/ -/0/ Exonic hg18 - - - - TICdb

ChimerPUB

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The fusion gene pair CDH11--USP6 information is not available in CHIMERPUB (CHIMERDB 3.0) database.

ChimerSEQ

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The fusion gene pair CDH11--USP6 information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
CDH11_USP6chr16/65155882/ chr17/5033229/ 16q21 17p13.2 Exonic hg19 - Inter-chr NA AY380226 - ChiTaRs
CDH11_USP6chr16/65155882/ chr17/5033659/ 16q21 17p13.2 Exonic hg19 - Inter-chr NA AY380225 - ChiTaRs
CDH11_USP6chr16/65155882/ chr17/5028508/ 16q21 17p13.2 Exonic hg19 - Inter-chr NA AY380222 - ChiTaRs
CDH11_USP6chr16/65155882/ chr17/5033660/ 16q21 17p13.2 Exonic hg19 - Inter-chr NA AY380224 - ChiTaRs

ChiTaRS 2.1

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The fusion gene pair CDH11--USP6 information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human AY380226CDH11--USP6 CDH1116 65155782 65155882 - 1 101 100 USP617 5033229 5033906 + 99 337 100
Human AY380225CDH11--USP6 CDH1116 65155782 65155882 - 1 101 100 USP617 5033659 5033906 + 98 183 100
Human AY380223CDH11--USP6 CDH1116 65087706 65155882 - 1 226 100 USP617 5033229 5033906 + 224 462 100
Human AY380222CDH11--USP6 CDH1116 65087707 65155882 - 1 225 100 USP617 5028508 5033906 + 224 520 100
Human AY380224CDH11--USP6 CDH1116 65087706 65155882 - 1 226 100 USP617 5033660 5033906 + 224 308 100

FARE-CAFE

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The fusion gene pair CDH11--USP6 information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
CDH11-USP6 Aneurysmal bone cyst FISH,RT-PCR t(16;17)(q22;p13) PubMed:15026324

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
CDH11-USP6 CDH11-USP6-Isoform1 CDH11 65087791 1 0 USP6 5033229 1 1 TTCGTGTTGTCATTTGTTGAGTGACCAATCAGATGGGTGGAGTGTGTTACAGAAATTGGCAGCAAGTATCCAATGGGTGAAGAAGGAAACTGGGCATCTCTGTGGCCCTGAACATCCCAGGAGGCCGATCGTACAGAGACCTCTGGTGCCTGACCGCAGTTCACATCCACATCCCTGGAATAGACCATCACAGGCTCTTCACCCTTGGCA _ AY380223
CDH11-USP6 CDH11-USP6-Isoform2 CDH11 65087791 1 0 USP6 5033660 1 0 TTCGTGTTGTCATTTGTTGAGTGACCAATCAGATGGGTGGAGTGTGTTACAGAAATTGGCAGCAAGTATCCAATGGGTGAAGAAGGATGGACATGGTAGAGAATGCAGATAGTTTGCAGGCACAGGAGCGGAAGGACATACTTATGAAGTATGACAAGGGACACCGAG _ AY380224
CDH11-USP6 CDH11-USP6-Isoform3 CDH11 65155882 0 0 USP6 5033229 1 1 GTGAATGGGACCGGGACTGGGGCCGGGACTGACACCGCAGCGCTTGCCCTGCGCCAGGGACTGGCGGCTCGGAGGTTGCGTCCACCCTCAAGGGCCCCAGGAAACTGGGCATCTCTGTGGCCCTGAACATCCCAGGAGGCCGATCGTACAGAGACCTCTGGTGCCTGACCGCAGTTCACATCCACATCCCTGGAATAGACCATCACAGGC _ AY380226

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
CDH11-USP6 CDH11-USP6-Isoform1 1) Cadherin
1) LRR_4 , Cadherin , Lectin_C , Botulinum_HA-17 , RicinB_lectin_2
1) RabGAP-TBC
2) UCH
1) Ras , RabGAP-TBC
2) ubiquitin , UCH , EnY2 , Sgf11
CDH11 1) Cadherin
2) Cadherin_C
1) LRR_4 , Cadherin , Lectin_C , Botulinum_HA-17 , RicinB_lectin_2
2) Arm
USP6 1) RabGAP-TBC
2) UCH
1) Ras , RabGAP-TBC
2) ubiquitin , UCH , EnY2 , Sgf11
1) Cadherin_C
1) Arm
CDH11-USP6 CDH11-USP6-Isoform2 1) Cadherin
1) LRR_4 , Cadherin , Lectin_C , Botulinum_HA-17 , RicinB_lectin_2
1) RabGAP-TBC
2) UCH
1) Ras , RabGAP-TBC
2) ubiquitin , UCH , EnY2 , Sgf11
CDH11 1) Cadherin
2) Cadherin_C
1) LRR_4 , Cadherin , Lectin_C , Botulinum_HA-17 , RicinB_lectin_2
2) Arm
USP6 1) RabGAP-TBC
2) UCH
1) Ras , RabGAP-TBC
2) ubiquitin , UCH , EnY2 , Sgf11
1) Cadherin_C
1) Arm
CDH11-USP6 CDH11-USP6-Isoform3 1) Cadherin
1) LRR_4 , Cadherin , Lectin_C , Botulinum_HA-17 , RicinB_lectin_2
1) RabGAP-TBC
2) UCH
1) Ras , RabGAP-TBC
2) ubiquitin , UCH , EnY2 , Sgf11
CDH11 1) Cadherin
2) Cadherin_C
1) LRR_4 , Cadherin , Lectin_C , Botulinum_HA-17 , RicinB_lectin_2
2) Arm
USP6 1) RabGAP-TBC
2) UCH
1) Ras , RabGAP-TBC
2) ubiquitin , UCH , EnY2 , Sgf11
1) Cadherin_C
1) Arm

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
CDH11-USP6 hsa-miR-26b-5phsa-miR-423-5p hsa-miR-335-5phsa-miR-124-3phsa-miR-204-5p Microarray,NGS

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
CDH11-USP6 NM_001797.2 1) TRIM28_HUMAN
2) MITF_HUMAN
3) RBL2_HUMAN
4) STAT1_HUMAN
5) P53_HUMAN
6) RUNX1_HUMAN
7) PRDM14_HUMAN
8) ESTROGEN RECEPTOR ALPHA_HUMAN
9) EGR1_HUMAN
10) FOS_HUMAN
11) GATA2_HUMAN
12) GATA3_HUMAN
13) SOX2_HUMAN
14) E2F1_HUMAN
15) TAL1_HUMAN
16) CTCF_HUMAN
17) ESR1_HUMAN
18) ESR2_HUMAN
19) SETDB1_HUMAN
20) TRIM24_HUMAN
21) BRG1_HUMAN
22) HIF1A_HUMAN
23) HNF4A_HUMAN
24) TFAP2C_HUMAN
25) FOXA1_HUMAN A
26) CEBPA_HUMAN A
27) CTCF_HUMAN
- 1) 17542650
2) 21258399
3) 20385362
4) 19122651
5) 21394211
6) 20019798
7) 20953172
8) 20547749
9) 20690147
10) 20139302
11) 21808000
12) 21878914
13) 21211035
14) 21310950
15) 21795385
16) 21795385
17) 21235772
18) 21430779
19) 21164480
20) 19505939
21) 21447827
22) 21646355
23) 21572391
24) 21572391 A
25) 20219941 A
26) 20219941

TicDB

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The fusion gene pair CDH11--USP6 information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
CDH11 USP6 AY380223 TTCGTGTTGTCATTTGTTGAGTGACCAATCAGATGGGTGGAGTGTGTTACAGAAATTGGCAGCAAGTATCCAATGGGTGAAGAAGGAAACTGGGCATCTCTGTGGCCCTGAACATCCCAGGAGGCCGATCGTACAGAGACCTCTGGTGCCTGACCGCAGTTCACATCCACATCCCTGGAATAGACCATCACAGGCTCTTCACCCTTGGCA
CDH11 USP6 AY380224 TTCGTGTTGTCATTTGTTGAGTGACCAATCAGATGGGTGGAGTGTGTTACAGAAATTGGCAGCAAGTATCCAATGGGTGAAGAAGGATGGACATGGTAGAGAATGCAGATAGTTTGCAGGCACAGGAGCGGAAGGACATACTTATGAAGTATGACAAGGGACACCGAG
CDH11 USP6 AY380226 GTGAATGGGACCGGGACTGGGGCCGGGACTGACACCGCAGCGCTTGCCCTGCGCCAGGGACTGGCGGCTCGGAGGTTGCGTCCACCCTCAAGGGCCCCAGGAAACTGGGCATCTCTGTGGCCCTGAACATCCCAGGAGGCCGATCGTACAGAGACCTCTGGTGCCTGACCGCAGTTCACATCCACATCCCTGGAATAGACCATCACAGGC

TUMOR FUSION Gene Data Portal

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The fusion gene pair CDH11--USP6 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair CDH11--USP6 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair CDH11--USP6 information is not available in ConjoinG Database.

1000Genome

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Fusion gene CDH11--USP6 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene CDH11--USP6 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene CDH11--USP6 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene CDH11--USP6 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene CDH11--USP6 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair CDH11--USP6 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene CDH11--USP6 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene CDH11--USP6 has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene CDH11 is not a known oncogene according to ONGENE database.


The tail gene USP6 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene CDH11 is cancer associated according to Bushman Cancer Gene database.


The tail gene USP6 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene CDH11 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene USP6 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene CDH11--USP6 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene CDH11--USP6 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair CDH11--USP6 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene CDH11--USP6 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene CDH11--USP6 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair CDH11--USP6 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair CDH11--USP6 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair CDH11--USP6 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene CDH11--USP6 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair CDH11--USP6 information is not available in ChromothripsisDB database.