CD74--ROS1

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

CD74 ROS1

COSMIC

The fusion gene pair CD74--ROS1 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair CD74--ROS1 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
CD74_ROS1-/627/ -/5757/ Exonic hg19 - - - Kinase; Oncogene; Cosmic_recurrent
CD74_ROS1-/627/ -/5448/ Exonic hg19 - - - Kinase; Oncogene; Cosmic_recurrent
CD74_ROS1-/-/ -/-/ - hg19 non small cell lung cancer - 18083107 Kinase; Oncogene; Cosmic_nonrecurrent
CD74_ROS1-/-/ -/-/ - hg19 lung adenocarcinoma - 22140546 Kinase; Oncogene; Cosmic_nonrecurrent
CD74_ROS1-/-/ -/-/ - hg19 non small cell lung cancer - 22215748 Kinase; Oncogene; Cosmic_nonrecurrent
CD74_ROS1-/-/ -/-/ - hg19 lung cancer - 22327623 Kinase; Oncogene; Cosmic_nonrecurrent
CD74_ROS1-/-/ -/-/ - hg19 non small cell lung cancer - 22661537 Kinase; Oncogene; Cosmic_nonrecurrent
CD74_ROS1-/-/ -/-/ - hg19 lung adenocarcinoma - 23788756 Kinase; Oncogene; Cosmic_nonrecurrent
CD74_ROS1-/-/ -/-/ - hg19 lung adenocarcinoma - 23724914 Kinase; Oncogene; Cosmic_nonrecurrent
CD74_ROS1-/-/ -/-/ - hg19 lung adenocarcinoma - 24700479 Kinase; Oncogene; Cosmic_nonrecurrent
CD74_ROS1-/-/ -/-/ - hg19 non small cell lung cancer - 24810493 Kinase; Oncogene; Cosmic_nonrecurrent
CD74_ROS1-/-/ -/-/ - hg19 lung adenocarcinoma - 24469108 Kinase; Oncogene; Cosmic_nonrecurrent
CD74_ROS1-/-/ -/-/ - hg19 lung adenocarcinoma - 25157770 Kinase; Oncogene; Cosmic_nonrecurrent
CD74_ROS1-/-/ -/-/ - hg19 non small cell lung cancer - 23877438 Kinase; Oncogene; Cosmic_nonrecurrent

ChimerPUB

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The fusion gene pair CD74--ROS1 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
CD74_ROS1- 25567305non small cell lung cancer;lung cancer;adenocarcinoma FISH - Among these positive cases, 15 were CD74-ROS1, 13 were SLC34A2-ROS1, 13 were SDC4-ROS1 and 12 were TPM3-ROS1. /// "Among these positive cases, 15 were CD74-ROS1, 13 were SLC34A2-ROS1, 13 were SDC4-ROS1 and 12 were TPM3-ROS1. "
CD74_ROS1- 22919003non small cell lung cancer;lung cancer FISH;PCR - The patient and one TMA sample displayed expression of the recently identified SDC4-ROS1 fusion, whereas two TMA samples expressed the CD74-ROS1 fusion and two others expressed the SLC34A2-ROS1 fusion. /// "The patient and one TMA sample displayed expression of the recently identified SDC4-ROS1 fusion, whereas two TMA samples expressed the CD74-ROS1 fusion and two others expressed the SLC34A2-ROS1 fusion. "
CD74_ROS1- 24759083lung cancer - - Here we report the application of CRISPR/Cas technology to successfully generate several types of chromosomal rearrangements implicated as driver events in lung cancer, including the CD74-ROS1 translocation event and the EML4-ALK and KIF5B-RET inversion events. /// "Here we report the application of CRISPR/Cas technology to successfully generate several types of chromosomal rearrangements implicated as driver events in lung cancer, including the CD74-ROS1 translocation event and the EML4-ALK and KIF5B-RET inversion events. "
CD74_ROS1- 25733882non small cell lung cancer;lung cancer - - In vivo, PF-06463922 showed marked antitumor activity in tumor models expressing FIG-ROS1, CD74-ROS1, and the CD74-ROS1(G2032R) mutation. /// "In vivo, PF-06463922 showed marked antitumor activity in tumor models expressing FIG-ROS1, CD74-ROS1, and the CD74-ROS1(G2032R) mutation. "

ChimerSEQ

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The fusion gene pair CD74--ROS1 information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
CD74_ROS1chr5/149784242/- chr6/117647577/- 5q32 6q22.1 Exonic hg19 In-Frame Inter-chr LUAD TCGA-86-8278-01A Kinase; Oncogene; FusionScan
CD74_ROS1chr5/149784242/- chr6/117645578/- 5q32 6q22.1 Exonic hg19 In-Frame Inter-chr LUAD TCGA-64-1680-01A Kinase; Oncogene; FusionScan
CD74_ROS1chr5/149784242/- chr6/117645578/- 5q32 6q22.1 Exonic hg19 In-Frame Inter-chr LUAD TCGA-86-8278-01A Kinase; Oncogene; FusionScan
CD74_ROS1chr5/149784242/- chr6/117645577/- 5q32 6q22.1 Exonic hg19 In-Frame Inter-chr LUAD TCGA-64-1680-01A Kinase; Oncogene; TopHat-Fusion
CD74_ROS1chr5/149784242/- chr6/117645577/- 5q32 6q22.1 Exonic hg19 In-Frame Inter-chr LUAD TCGA-86-8278-01A Kinase; Oncogene; TopHat-Fusion
CD74_ROS1chr5/149792312/ chr6/117609655/ 5q32 6q22.1 Exonic hg19 - Inter-chr NA EU236945 Kinase; Oncogene; ChiTaRs
CD74_ROS1chr5/149792317/ chr6/117609626/ 5q32 6q22.1 Exonic hg19 - Inter-chr non small cell lung cancer AB795245 Kinase; Oncogene; ChiTaRs

ChiTaRS 2.1

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The fusion gene pair CD74--ROS1 information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human EU236945CD74--ROS1 CD745 149784243 149792312 - 1 625 100 ROS16 117609655 117645580 - 624 2112 100
Human AB795245CD74--ROS1 CD745 149784243 149792317 - 1 630 100 ROS16 117609626 117645580 - 629 2146 100

FARE-CAFE

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The fusion gene pair CD74--ROS1 information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
CD74-ROS1 lung cancer RT-PCR,5′ RACE PubMed:18083107

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
CD74-ROS1 CD74-ROS1 CD74 149784267 0 0 ROS1 117645544 0 1 aagcccactgacgctccaccgaaagAtgatttttggataccagaaacaagtttcatactt 18083107 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
CD74-ROS1 CD74-ROS1 - - 1) fn3
1) RGM_N , SH2 , CH , HH_signal , IL12p40_C , IL6Ra-bind , Lipocalin , EPO_TPO , Hormone_1 , IL2 , IL7 , PDZ , Rad60-SLD , V-set , EpoR_lig-bind , Hormone_recep , IL4 , Ig_2 , Pkinase , Recep_L_domain , fn3 , Glyco_hydro_28 , I-set , IL6 , Lectin_C , RGM_C , SBP_bac_1
CD74 1) MHC2-interact
-ROS1 1) fn3
2) Pkinase_Tyr
1) RGM_N , SH2 , CH , HH_signal , IL12p40_C , IL6Ra-bind , Lipocalin , EPO_TPO , Hormone_1 , IL2 , IL7 , PDZ , Rad60-SLD , V-set , EpoR_lig-bind , Hormone_recep , IL4 , Ig_2 , Pkinase , Recep_L_domain , fn3 , Glyco_hydro_28 , I-set , IL6 , Lectin_C , RGM_C , SBP_bac_1
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) MHC2-interact
-

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
CD74-ROS1 hsa-miR-26b-5p _ Microarray

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
CD74-ROS1 NM_001025158.2 1) HNF4A_HUMAN
2) NR1H3_HUMAN
3) MITF_HUMAN
4) FOS_HUMAN
5) TAL1_HUMAN
6) BRG1_HUMAN
1) EGR1_HUMAN
2) FOXA1_HUMAN
3) CTCF_HUMAN
4) AR_HUMAN
1) 21646355
2) 22292898
3) 21258399
4) 20139302
5) 21795385
6) 19505939

TicDB

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The fusion gene pair CD74--ROS1 information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
CD74 ROS1 18083107 aagcccactgacgctccaccgaaagAtgatttttggataccagaaacaagtttcatactt

TUMOR FUSION Gene Data Portal

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The fusion gene pair CD74--ROS1 information is available in TUMOR FUSION Gene Data Portal.
CancerTCGA_barcodeFusionPairEvalue5'Gene_Junction3'Gene_JunctionTierFrameTNWGS_validation
LUAD 64-1680-01A CD74__ROS1 1.6 5:149784243/-1 6:117645578/-1 tier1 In-frame 3294 validated
LUAD 86-8278-01A CD74__ROS1 1.6 5:149784243/-1 6:117645578/-1 tier1 In-frame 3295 NA

FusionCancer

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The fusion gene pair CD74--ROS1 information is available in FusionCancer Database.
Database_IDHead_gene_symbolHead_breakpoint_locationTail_gene_symbolTail_breakpoint_locationCancer_typeSRA
FUSC003425CD74chr5:149792498ROS1chr6:117609529Lung cancerERR164621
FUSC003425CD74chr5:149784243ROS1chr6:117645578Lung cancerERR164621
FUSC003425CD74chr5:149784243ROS1chr6:117645578Lung cancerERR164621

ConjoinG

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The fusion gene pair CD74--ROS1 information is not available in ConjoinG Database.

1000Genome

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Fusion gene CD74--ROS1 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene CD74--ROS1 is found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016)

Bodymap2

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Fusion gene CD74--ROS1 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene CD74--ROS1 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene CD74--ROS1 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair CD74--ROS1 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene CD74--ROS1 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene CD74--ROS1 has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene CD74 is not a known oncogene according to ONGENE database.


The tail gene ROS1 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene CD74 is cancer associated according to Bushman Cancer Gene database.


The tail gene ROS1 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene CD74 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene ROS1 is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene CD74--ROS1 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene CD74--ROS1 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair CD74--ROS1 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene CD74--ROS1 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene CD74--ROS1 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair CD74--ROS1 information is available in Klijn Dataset.

Cell lineGene 5'Gene 3'Read evidenceKinaseChromosome 5'Position 5'Chromosome 3'Position 3'Fusion type DNAFusion type RNAFusion protein lengthTissueKnown Fusion
HCC1493CD74ROS159Y51497842436117645578TranslocinFrame703BreastFull fusion known

Fimereli_Dataset

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The fusion gene pair CD74--ROS1 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair CD74--ROS1 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene CD74--ROS1 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair CD74--ROS1 information is not available in ChromothripsisDB database.