CCND1--CDK4

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

CCND1 CDK4

COSMIC

The fusion gene pair CCND1--CDK4 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair CCND1--CDK4 information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair CCND1--CDK4 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
CCND1_CDK4- 12148857squamous cell carcinoma;retinoblastoma FISH - The p16 gene regulates cyclin D1-CDK4 activity and prevents retinoblastoma tumor suppressor gene phosphorylation, thereby downregulating cellular proliferation.
CCND1_CDK4- 10597234- - - Utilizing a tet-regulated gene expression system, we have shown that proliferation of stably transfected primary REFs in vitro and in vivo is dependent on the continued expression of the cyclin D1-cdk4 fusion gene. /// Conditional transformation of rat embryo fibroblast cells by a cyclin D1-cdk4 fusion gene..
CCND1_CDK411p15.5 / 23318451- - - Thus, we conclude that TRIM3 is a tumor suppressor mapping to chromosome 11p15.5 and that it might block tumor growth by sequestering p21 and preventing it from facilitating the accumulation of cyclin D1-cdk4.
CCND1_CDK4t(11;14)(q13;q32) / 9001420neuroectodermal tumor;non Hodgkin Lymphoma - - Cyclin D1 was dominant among the D-type cyclins, formed abundant complexes with cyclin-dependent kinase (Cdk) Cdk4 rather than Cdk6, and the immunoprecipitated cyclin D1/Cdk4 holoenzyme was active as a pRB kinase.
CCND1_CDK4- 8957087melanoma - - In contrast to observations in other cell types, there was an increased association of both p21Cip1/WAF1 and p27Kip1 with cyclin D1/cdk4 and with cyclin E/cdk2 during TGF-beta mediated arrest of asynchronously growing cells. /// "It has been proposed that in TGF-beta arrested epithelial cells, up-regulation of p15INK4B and of p15INK4B binding to cdk4 serves to destabilize the association of p27Kip1 with cyclin D1/cdk4, promoting p27Kip1 binding and inhibition of cyclin E/cdk2. "
CCND1_CDK4- 15474160adenocarcinoma;retinoblastoma - - Loss of heterozygosity abnormalities in RB1 and CKDN2A coexisted with altered cyclin D1-cdk4 complex immunoreactivity only in 2 patients, both less than 50 years of age.
CCND1_CDK4- 16293976- PCR - Disruptions at p16INK4A and/or cdk4/cyclin D1 concomitantly occurring with TP53 LOH may participate in the development of a subset of endometrioid-type ECs.. /// "p16INK4A alterations (LOH and gene deletion) occurred concomitantly, with 3 tumors showing the TP53 allelic loss, whereas the cyclin D1/cdk4 complex was overexpressed in a case with TP53 LOH. "

ChimerSEQ

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The fusion gene pair CCND1--CDK4 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair CCND1--CDK4 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair CCND1--CDK4 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair CCND1--CDK4 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair CCND1--CDK4 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair CCND1--CDK4 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair CCND1--CDK4 information is not available in ConjoinG Database.

1000Genome

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Fusion gene CCND1--CDK4 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene CCND1--CDK4 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene CCND1--CDK4 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene CCND1--CDK4 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene CCND1--CDK4 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair CCND1--CDK4 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene CCND1--CDK4 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene CCND1--CDK4 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene CCND1 is a known oncogene according to ONGENE database.


The tail gene CDK4 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene CCND1 is cancer associated according to Bushman Cancer Gene database.


The tail gene CDK4 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene CCND1 is proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene CDK4 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene CCND1--CDK4 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene CCND1--CDK4 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair CCND1--CDK4 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene CCND1--CDK4 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene CCND1--CDK4 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair CCND1--CDK4 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair CCND1--CDK4 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair CCND1--CDK4 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene CCND1--CDK4 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair CCND1--CDK4 information is not available in ChromothripsisDB database.