CCNB1--CDK1

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

CCNB1 CDK1

COSMIC

The fusion gene pair CCNB1--CDK1 information is not available in COSMIC database.

ChimerKB

Top
The fusion gene pair CCNB1--CDK1 information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

Top
The fusion gene pair CCNB1--CDK1 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
CCNB1_CDK1- 17472438- - - Importantly, we discovered that cytoplasmic cyclin B1-Cdk1 activity can be maintained even when cyclin B1 translocates to the nucleus in prophase. /// "By quantifying both dephosphorylation of Cdk1 and phosphorylation of the Cdk1 target anaphase-promoting complex/cyclosome 3, we disclose how cyclin B1-Cdk1 continues to be activated after centrosome separation. " /// "These experimental data are fitted into a model describing cyclin B1-Cdk1 activation in human cells, revealing a striking resemblance to a bistable circuit. " /// "In line with the observed kinetics, cyclin B1-Cdk1 levels required to enter mitosis are lower than the amount of cyclin B1-Cdk1 needed for mitotic progression. " /// " Activation of cyclin B1-cyclin-dependent kinase 1 (Cdk1), triggered by a positive feedback loop at the end of G2, is the key event that initiates mitotic entry. " /// We propose that gradually increasing cyclin B1-Cdk1 activity after centrosome separation is critical to coordinate mitotic progression.. /// We use a novel approach to determine the temporal development of cyclin B1-Cdk1 activity in single cells. /// Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression..
CCNB1_CDK1- 11063929- - - Nuclear events of mitosis are initiated when the protein kinase cyclin-B1-Cdk1 is translocated into the nucleus during prophase. /// Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C.. /// Recent work has unveiled many of the mechanisms that govern the localization of cyclin-B1-Cdk1 and its regulator Cdc25C.
CCNB1_CDK1- 22726437- - - Mitosis is triggered by the activation of Cdk1-cyclin B1 and its translocation from the cytoplasm to the nucleus. /// "Interfering with the abruptness of Cdk1-cyclin B1 translocation affects the timing and synchronicity of subsequent mitotic events, underscoring the functional importance of this feedback. " /// We used chemical biology approaches and live-cell microscopy to show that nuclear Cdk1-cyclin B1 promotes the translocation of Cdk1-cyclin B1 to the nucleus. /// Positive feedback loops regulate the activation of Cdk1-cyclin B1 and help make the process irreversible and all-or-none in character. /// "Here we examine whether an analogous process, spatial positive feedback, regulates Cdk1-cyclin B1 redistribution. "

ChimerSEQ

Top
The fusion gene pair CCNB1--CDK1 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

Top
The fusion gene pair CCNB1--CDK1 information is not available in CHITARS database.

FARE-CAFE

Top
The fusion gene pair CCNB1--CDK1 information is not available in FARE-CAFE.

TicDB

Top
The fusion gene pair CCNB1--CDK1 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

Top
The fusion gene pair CCNB1--CDK1 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

Top
The fusion gene pair CCNB1--CDK1 information is not available in FusionCancer Database.

ConjoinG

Top
The fusion gene pair CCNB1--CDK1 information is not available in ConjoinG Database.

1000Genome

Top
Fusion gene CCNB1--CDK1 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

Top
Fusion gene CCNB1--CDK1 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

Top
Fusion gene CCNB1--CDK1 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

Top
Fusion gene CCNB1--CDK1 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

Top
Fusion gene CCNB1--CDK1 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

Top
The fusion gene pair CCNB1--CDK1 information is not available in Babiceanu_Dataset.

Banned_Dataset

Top
Fusion gene CCNB1--CDK1 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

Top
Fusion gene CCNB1--CDK1 has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

Top
The head gene CCNB1 is a known oncogene according to ONGENE database.


The tail gene CDK1 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

Top
The head gene CCNB1 is cancer associated according to Bushman Cancer Gene database.


The tail gene CDK1 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

Top
The head gene CCNB1 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene CDK1 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

Top
Fusion gene CCNB1--CDK1 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

Top
Fusion gene CCNB1--CDK1 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

Top
The fusion gene pair CCNB1--CDK1 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

Top
Fusion gene CCNB1--CDK1 is not found in pancreatic tumor dataset, published here.

GTEx

Top
Fusion gene CCNB1--CDK1 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

Top
The fusion gene pair CCNB1--CDK1 information is not available in Klijn Dataset.

Fimereli_Dataset

Top
The fusion gene pair CCNB1--CDK1 information is not found in Fimereli_Dataset.

Literature

Top
The fusion gene pair CCNB1--CDK1 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

Top
Fusion gene CCNB1--CDK1 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

Top
The fusion gene pair CCNB1--CDK1 information is not available in ChromothripsisDB database.