CCDC6--RET

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

CCDC6 RET

COSMIC

The fusion gene pair CCDC6--RET information is available in COSMIC database.

Link
CCDC6--RET

ChimerKB

Top
The fusion gene pair CCDC6--RET information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
CCDC6_RET-/535/ -/2369/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
CCDC6_RET-/685/ -/2369/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
CCDC6_RET-/535+1111/ -/2369-807/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
CCDC6_RET-/535+1054/ -/2369-?/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
CCDC6_RET-/1462+848/ -/2237/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
CCDC6_RET-/-/ -/-/ - hg19 follicular variant papillary thyroid carcinoma - 16784981 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 17464312 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 18226854 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 - - 19744101 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 thyroid cancer - 20703476 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 20564403 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 18757433 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 21498916 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 20840674 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 lung cancer - 22327623 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 non small cell lung cancer - 23150706 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 thyroid cancer - 23436219 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 thyroid papillary carcinoma - 2406025 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 non small cell lung cancer - 24133367 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 10951397 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 12720532 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 16015630 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 11747322 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 thyroid cancer - 19495791 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 10083732 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 goitre - 11117781 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 11927965 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 goitre - 21411555 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 goitre - 21048359 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 15876154 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 10675479 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 chronic thyroiditis - 11493988 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 thyroid cancer - 8545102 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 22481925 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 18393128 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 9516913 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 9528832 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 goitre - 9466701 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 thyroid cancer - 9466701 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 11786418 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 thyroid disease - 9508203 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 10720057 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary carcinoma - 9001272 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 goitre - 9001272 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 chronic thyroiditis - 9001272 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 10946873 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 goitre - 11788677 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 thyroid cancer - 11788677 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 thyroid cancer - 15788648 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 goitre - 15788648 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 11443191 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 goitre - 11443191 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 follicular thyroid carcinoma - 14668719 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 goitre - 14668719 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 10931090 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 10773666 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 goitre - 10773666 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 goitre - 11117782 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 11117782 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 9935226 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 16595592 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 chronic thyroiditis - 16595592 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid cancer - 22745248 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 23806056 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 goitre - 12057919 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 goitre - 21173509 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 thyroid nodules - 21173509 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid cancer - 9669285 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 8634704 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 thyroid cancer - 24327398 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 non small cell lung cancer - 24346091 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 papillary thyroid carcinoma - 24417340 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 non small cell lung cancer - 24810493 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 lung adenocarcinoma - 24469108 Oncogene; Cosmic_nonrecurrent
CCDC6_RET-/-/ -/-/ - hg19 thyroid carcinoma - 25111330 Oncogene; Cosmic_nonrecurrent
CCDC6_RETchr10/61335968/ chr10/42930132/ Exonic hg18 - - - Oncogene; ChimerDB2
CCDC6_RETchr10/61336243/ chr10/42932037/ Exonic hg18 - - - Oncogene; ChimerDB2
CCDC6_RETchr10/61336223/ chr10/42932037/ Exonic hg18 - - - Oncogene; ChimerDB2
CCDC6_RET-/0/ -/0/ Exonic hg18 - - - Oncogene; TICdb
CCDC6_RET-/848/ -/3362/ Exonic hg18 - - - Oncogene; TICdb

ChimerPUB

Top
The fusion gene pair CCDC6--RET information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
CCDC6_RET- 23154560lung cancer;adenocarcinoma - - In this study, we report identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line LC-2/ad. /// "In this study, we report identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line LC-2/ad. " /// "Identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line, LC-2/ad.. "
CCDC6_RET- 20587502thyloid cancer;leukemia - - We readily identified for the first time the genomic fusion sequences of CCDC6-RET in TPC-1 cells and FGFR1OP2-FGFR1 in KG-1 cells. /// We readily identified for the first time the genomic fusion sequences of CCDC6-RET in TPC-1 cells and FGFR1OP2-FGFR1 in KG-1 cells.
CCDC6_RET- 24133367non small cell lung cancer;lung cancer;adenocarcinoma - - Two KIF5B-RET fusions and one CCDC6-RET fusion were identified.

ChimerSEQ

Top
The fusion gene pair CCDC6--RET information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
CCDC6_RETchr10/61665879/- chr10/43612031/+ 10q21.2 10q11.21 Exonic hg19 In-Frame Intra-chr LUAD TCGA-75-6203-01A Oncogene; TopHat-Fusion
CCDC6_RETchr10/61666237/ chr10/43612032/ 10q21.2 10q11.21 Exonic hg19 - Intra-chr NA D90075 Oncogene; ChiTaRs
CCDC6_RETchr10/61666217/ chr10/43612032/ 10q21.2 10q11.21 Exonic hg19 - Intra-chr NA M31213 Oncogene; ChiTaRs
CCDC6_RETchr10/61665962/ chr10/43610127/ 10q21.2 10q11.21 Exonic hg19 - Intra-chr NA AF395885 Oncogene; ChiTaRs
CCDC6_RETchr10/61666182/ chr10/43612032/ 10q21.2 10q11.21 Exonic hg19 - Intra-chr NA AB698669 Oncogene; ChiTaRs
CCDC6_RETchr10/61665880/- chr10/43612032/+ 10q21.2 10q11.21 Exonic hg19 In-frame Intra-chr THCA TCGA-BJ-A0ZJ-01A Oncogene; PRADA
CCDC6_RETchr10/61665880/- chr10/43612032/+ 10q21.2 10q11.21 Exonic hg19 In-frame Intra-chr THCA TCGA-BJ-A28Z-01A Oncogene; PRADA
CCDC6_RETchr10/61554231/- chr10/43612032/+ 10q21.2 10q11.21 Exonic hg19 In-frame Intra-chr THCA TCGA-CE-A13K-01A Oncogene; PRADA
CCDC6_RETchr10/61665880/- chr10/43612032/+ 10q21.2 10q11.21 Exonic hg19 In-frame Intra-chr THCA TCGA-DJ-A3V3-01A Oncogene; PRADA
CCDC6_RETchr10/61665880/- chr10/43612032/+ 10q21.2 10q11.21 Exonic hg19 In-frame Intra-chr THCA TCGA-DJ-A4UQ-01A Oncogene; PRADA
CCDC6_RETchr10/61665880/- chr10/43612032/+ 10q21.2 10q11.21 Exonic hg19 In-frame Intra-chr THCA TCGA-DJ-A4V5-01A Oncogene; PRADA
CCDC6_RETchr10/61665880/- chr10/43612032/+ 10q21.2 10q11.21 Exonic hg19 In-frame Intra-chr THCA TCGA-DO-A1JZ-01A Oncogene; PRADA
CCDC6_RETchr10/61665880/- chr10/43612032/+ 10q21.2 10q11.21 Exonic hg19 In-frame Intra-chr THCA TCGA-E3-A3E0-01A Oncogene; PRADA
CCDC6_RETchr10/61665880/- chr10/43612032/+ 10q21.2 10q11.21 Exonic hg19 In-frame Intra-chr THCA TCGA-EL-A3TB-01A Oncogene; PRADA
CCDC6_RETchr10/61665880/- chr10/43612032/+ 10q21.2 10q11.21 Exonic hg19 In-frame Intra-chr THCA TCGA-EL-A3ZP-01A Oncogene; PRADA
CCDC6_RETchr10/61665880/- chr10/43612032/+ 10q21.2 10q11.21 Exonic hg19 In-frame Intra-chr THCA TCGA-ET-A3DR-01A Oncogene; PRADA
CCDC6_RETchr10/61665880/- chr10/43612032/+ 10q21.2 10q11.21 Exonic hg19 In-frame Intra-chr THCA TCGA-FK-A3SE-01A Oncogene; PRADA

ChiTaRS 2.1

Top
The fusion gene pair CCDC6--RET information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human D90075CCDC6--RET CCDC610 61665879 61666237 - 1 359 100 RET10 43612032 43612133 + 359 457 99
Human M31213CCDC6--RET CCDC610 61665879 61666217 - 18 355 99.8 RET10 43612032 43625788 + 355 3639 99
Human AF395885CCDC6--RET CCDC610 61665030 61665962 - 1 143 99.4 RET10 43610127 43613919 + 143 447 99.7
Human AB698669CCDC6--RET CCDC610 61665879 61666182 - 1 304 99.7 RET10 43612032 43622202 + 304 1386 100
Human AB698668CCDC6--RET CCDC610 61665879 61666182 - 1 304 99.7 RET10 43612032 43623717 + 304 1512 100

FARE-CAFE

Top
The fusion gene pair CCDC6--RET information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
CCDC6-RET Myeloproliferative disorder PCR,DNA sequencing,Southern blot,FISH t(5;10)(q33;q21) PubMed:11389034,10910073

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
CCDC6-RET CCDC6-RET-Isoform1 CCDC6 61553437 0 0 RET 43610053 1 1 CCCGAGTAGCTGGTATTACAGGCACACGGCACCACACCTGGCTGCTTTTTGTATtATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCCGGTG 10931090 _
CCDC6-RET CCDC6-RET-Isoform2 CCDC6 61665933 1 0 RET 43612032 1 0 TGCAAGGCACTGCAGGAGGAGAACCGCGACCTGCGCAAAGCCAGCGTTACCATcGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGGGAA 2406025 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
CCDC6-RET CCDC6-RET-Isoform1 - - 1) Pkinase_Tyr
1) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
CCDC6 1) DUF2046
-RET 1) Cadherin
2) Pkinase_Tyr
1) LRR_4 , Cadherin , Lectin_C , Botulinum_HA-17 , RicinB_lectin_2
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) DUF2046
2) Cadherin
1) LRR_4 , Cadherin , Lectin_C , Botulinum_HA-17 , RicinB_lectin_2
CCDC6-RET CCDC6-RET-Isoform2 1) DUF2046
- 1) Pkinase_Tyr
1) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
CCDC6 1) DUF2046
-RET 1) Cadherin
2) Pkinase_Tyr
1) LRR_4 , Cadherin , Lectin_C , Botulinum_HA-17 , RicinB_lectin_2
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) Cadherin
1) LRR_4 , Cadherin , Lectin_C , Botulinum_HA-17 , RicinB_lectin_2

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
CCDC6-RET hsa-miR-31-5phsa-miR-29a-3phsa-miR-215-5phsa-miR-192-5p hsa-miR-128-3phsa-miR-181a-5phsa-miR-331-5phsa-miR-342-3phsa-miR-99a-5phsa-miR-92a-3p Report assay,qPCR,Microarray

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
CCDC6-RET NM_005436.4 1) TRIM28_HUMAN
2) RB1_HUMAN
3) STAT1_HUMAN
4) RBL2_HUMAN
5) E2F4_HUMAN
6) PRDM14_HUMAN
7) ESTROGEN RECEPTOR ALPHA_HUMAN
8) ETS1_HUMAN
9) EGR1_HUMAN
10) GATA3_HUMAN
11) TAL1_HUMAN
12) CTCF_HUMAN
13) BRG1_HUMAN
14) TFAP2C_HUMAN
15) FOXA1_HUMAN
16) CEBPA_HUMAN
17) ESR1_HUMAN
18) ESR2_HUMAN
19) SPI1_HUMAN
1) SOX10_HUMAN
2) MITF_HUMAN
3) ZNF263_HUMAN
4) P53_HUMAN
5) FOS_HUMAN
6) FOXP1_HUMAN
1) 17542650
2) 20385362
3) 19122651
4) 20385362
5) 21247883
6) 20953172
7) 20547749
8) 20019798
9) 20690147
10) 21878914
11) 21795385
12) 21795385
13) 19505939
14) 21572391
15) 21572391
16) 20219941
17) 21235772
18) 21235772
19) 21241896

TicDB

Top
The fusion gene pair CCDC6--RET information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
CCDC6 RET 10931090 CCCGAGTAGCTGGTATTACAGGCACACGGCACCACACCTGGCTGCTTTTTGTATtATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCCGGTG
CCDC6 RET 2406025 TGCAAGGCACTGCAGGAGGAGAACCGCGACCTGCGCAAAGCCAGCGTTACCATcGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGGGAA

TUMOR FUSION Gene Data Portal

Top
The fusion gene pair CCDC6--RET information is available in TUMOR FUSION Gene Data Portal.
CancerTCGA_barcodeFusionPairEvalue5'Gene_Junction3'Gene_JunctionTierFrameTNWGS_validation
THCA BJ-A0ZJ-01A CCDC6__RET 0.34 10:61665880/-1 10:43612032/1 tier1 In-frame 3160 NA
THCA BJ-A28Z-01A CCDC6__RET 0.34 10:61665880/-1 10:43612032/1 tier1 In-frame 3161 NA
THCA CE-A13K-01A CCDC6__RET 0.34 10:61554231/-1 10:43612032/1 tier1 In-frame 3162 NA
THCA DJ-A3V3-01A CCDC6__RET 0.34 10:61665880/-1 10:43612032/1 tier1 In-frame 3163 NA
THCA DJ-A4UQ-01A CCDC6__RET 0.34 10:61665880/-1 10:43612032/1 tier1 In-frame 3164 NA
THCA DJ-A4V5-01A CCDC6__RET 0.34 10:61665880/-1 10:43612032/1 tier1 In-frame 3165 NA
THCA DO-A1JZ-01A CCDC6__RET 0.34 10:61665880/-1 10:43612032/1 tier1 In-frame 3166 NA
THCA E3-A3E0-01A CCDC6__RET 0.34 10:61665880/-1 10:43612032/1 tier1 In-frame 3167 NA
THCA EL-A3TB-01A CCDC6__RET 0.34 10:61665880/-1 10:43612032/1 tier1 In-frame 3168 validated
THCA EL-A3ZP-01A CCDC6__RET 0.34 10:61665880/-1 10:43612032/1 tier1 In-frame 3169 NA
THCA ET-A3DR-01A CCDC6__RET 0.34 10:61665880/-1 10:43612032/1 tier1 In-frame 3170 NA
THCA FK-A3SE-01A CCDC6__RET 0.34 10:61665880/-1 10:43612032/1 tier1 In-frame 3171 validated

FusionCancer

Top
The fusion gene pair CCDC6--RET information is not available in FusionCancer Database.

ConjoinG

Top
The fusion gene pair CCDC6--RET information is not available in ConjoinG Database.

1000Genome

Top
Fusion gene CCDC6--RET has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

Top
Fusion gene CCDC6--RET is found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016)

Bodymap2

Top
Fusion gene CCDC6--RET is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

Top
Fusion gene CCDC6--RET is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

Top
Fusion gene CCDC6--RET was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

Top
The fusion gene pair CCDC6--RET information is not available in Babiceanu_Dataset.

Banned_Dataset

Top
Fusion gene CCDC6--RET is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

Top
Fusion gene CCDC6--RET has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

Top
The head gene CCDC6 is a known oncogene according to ONGENE database.


The tail gene RET is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

Top
The head gene CCDC6 is cancer associated according to Bushman Cancer Gene database.


The tail gene RET is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

Top
The head gene CCDC6 is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene RET is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

Top
Fusion gene CCDC6--RET is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

Top
Fusion gene CCDC6--RET is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

Top
The fusion gene pair CCDC6--RET information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

Top
Fusion gene CCDC6--RET is not found in pancreatic tumor dataset, published here.

GTEx

Top
Fusion gene CCDC6--RET has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

Top
The fusion gene pair CCDC6--RET information is not available in Klijn Dataset.

Fimereli_Dataset

Top
The fusion gene pair CCDC6--RET information is not found in Fimereli_Dataset.

Literature

Top
The fusion gene pair CCDC6--RET information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

Top
Fusion gene CCDC6--RET is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

Top
The fusion gene pair CCDC6--RET information is not available in ChromothripsisDB database.