CARS--ALK

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

 CARS ALK

COSMIC

The fusion gene pair CARS--ALK information is available in COSMIC database.

Link
CARS--ALK

ChimerKB

 Top
The fusion gene pair CARS--ALK information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
CARS_ALK-/2065+1117/ -/4080-229/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
CARS_ALK-/2065/ -/4080/ Exonic hg19 - - - Oncogene; Cosmic_recurrent
CARS_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 12112524 Oncogene; Cosmic_nonrecurrent
CARS_ALK-/-/ -/-/ - hg19 inflammatory myofibroblastic tumour - 13679433 Oncogene; Cosmic_nonrecurrent
CARS_ALK-/0/ -/0/ Exonic hg18 - - - Oncogene; TICdb
CARS_ALK-/1116/ -/1703/ Exonic hg18 - - - Oncogene; TICdb

ChimerPUB

 Top
The fusion gene pair CARS--ALK information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
CARS_ALK- 13679433- FISH - Identification of CARS-ALK fusion in primary and metastatic lesions of an inflammatory myofibroblastic tumor..

ChimerSEQ

 Top
The fusion gene pair CARS--ALK information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

 Top
The fusion gene pair CARS--ALK information is not available in CHITARS database.

FARE-CAFE

 		Top
The fusion gene pair CARS--ALK information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
CARS-ALK Inflammatory myofibroblastic tumors FISH,G-Banding,RT-PCR t(2;11;2)(p23;p15;q31) PubMed: 12112524

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
CARS-ALK CARS-ALK-Isoform1 CARS 3033446 1 0 ALK 29446372 0 1 AAGATTGCCCGAGAGCAAAAAgTGTACCGCCGGAAGCACCAGGAG 12112524 _
CARS-ALK CARS-ALK-Isoform2 CARS _ _ 0 ALK 29446369 0 1 GTGCGGAAGATTGCCCAGAGCAAAAAgTGTACCGCCGGAAGCACCAGGCGCTG 13679433 _
CARS-ALK CARS-ALK-Isoform3 CARS 3032336 0 0 ALK 29446597 0 0 TGCCCACTGCTTTCTGCACATTGCCTCatAATTATTTTCCATATATCTGATTTTTA 13679433 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
CARS-ALK CARS-ALK-Isoform1 - - 1) MAM
2) Gly_rich
1) ig , Astacin , MATH
CARS 1) tRNA-synt_1e
1) DALR_2 , tRNA-synt_1e
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) tRNA-synt_1e
1) DALR_2 , tRNA-synt_1e
CARS-ALK CARS-ALK-Isoform2 - - 1) MAM
2) Gly_rich
1) ig , Astacin , MATH
CARS 1) tRNA-synt_1e
1) DALR_2 , tRNA-synt_1e
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) tRNA-synt_1e
1) DALR_2 , tRNA-synt_1e
CARS-ALK CARS-ALK-Isoform3 - - 1) MAM
2) Gly_rich
1) ig , Astacin , MATH
CARS 1) tRNA-synt_1e
1) DALR_2 , tRNA-synt_1e
ALK 1) MAM
2) Gly_rich
3) Pkinase_Tyr
1) ig , Astacin , MATH
2) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
1) tRNA-synt_1e
1) DALR_2 , tRNA-synt_1e

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
CARS-ALK hsa-miR-132-3p hsa-miR-155-5p, hsa-miR-652-3p, hsa-miR-92a-3p, hsa-miR-30a-5p Microarray

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
CARS-ALK NM_001014437.2 1) RBL2_HUMAN
2) E2F4_HUMAN
3) ESTROGEN RECEPTOR ALPHA_HUMAN
4) ETS1_HUMAN
5) EGR1_HUMAN
6) RB1_HUMAN
7) STAT1_HUMAN
8) MITF_HUMAN
9) FOS_HUMAN
10) GATA3_HUMAN
11) CTCF_HUMAN
12) HNF4A_HUMAN
13) TFAP2C_HUMAN
14) FOXA1_HUMAN
15) CEBPA_HUMAN
16) ESR1_HUMAN
17) NR1H3_HUMAN
18) SETDB1_HUMAN
1) TRIM28_HUMAN
2) P53_HUMAN
3) RUNX1_HUMAN
4) PRDM14_HUMAN
5) E2F1_HUMAN
6) SOX2_HUMAN
7) BRG1_HUMAN
1) 20385362
2) 21247883
3) 20547749
4) 20019798
5) 20690147
6) 20385362
7) 19122651
8) 21258399
9) 20139302
10) 21878914
11) 21795385
12) 21646355
13) 21572391
14) 21572391
15) 20219941
16) 21566084
17) 22292898
18) 21430779

TicDB

 		Top
The fusion gene pair CARS--ALK information is available in TICDB.
HeadGeneTailGenePubmedIDSequence
CARS ALK 12112524 AAGATTGCCCGAGAGCAAAAAgTGTACCGCCGGAAGCACCAGGAG
CARS ALK 13679433 GTGCGGAAGATTGCCCAGAGCAAAAAgTGTACCGCCGGAAGCACCAGGCGCTG
CARS ALK 13679433 TGCCCACTGCTTTCTGCACATTGCCTCatAATTATTTTCCATATATCTGATTTTTA

TUMOR FUSION Gene Data Portal

 		Top
The fusion gene pair CARS--ALK information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

 		Top
The fusion gene pair CARS--ALK information is not available in FusionCancer Database.

ConjoinG

 		Top
The fusion gene pair CARS--ALK information is not available in ConjoinG Database.

1000Genome

 		Top
Fusion gene CARS--ALK has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

 		Top
Fusion gene CARS--ALK is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

 		Top
Fusion gene CARS--ALK is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

 		Top
Fusion gene CARS--ALK is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

 		Top
Fusion gene CARS--ALK was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

 		Top
The fusion gene pair CARS--ALK information is not available in Babiceanu_Dataset.

Banned_Dataset

 		Top
Fusion gene CARS--ALK is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

 		Top
Fusion gene CARS--ALK has not been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. The list has been manually curated by FusionCatcher software. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

 		Top
The head gene CARS is not a known oncogene according to ONGENE database.


The tail gene ALK is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

 		Top
The head gene CARS is cancer associated according to Bushman Cancer Gene database.


The tail gene ALK is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

 		Top
The head gene CARS is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene ALK is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

 		Top
Fusion gene CARS--ALK is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

 		Top
Fusion gene CARS--ALK is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

 		Top
The fusion gene pair CARS--ALK information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

 		Top
Fusion gene CARS--ALK is not found in pancreatic tumor dataset, published here.

GTEx

 		Top
Fusion gene CARS--ALK has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

 		Top
The fusion gene pair CARS--ALK information is not available in Klijn Dataset.

Fimereli_Dataset

 		Top
The fusion gene pair CARS--ALK information is not found in Fimereli_Dataset.

Literature

 Top
The fusion gene pair CARS--ALK is found in known fusion genelist compiled from literature.

FusionGeneArticleLink
CARS--ALKThe pathology of soft tissue sarcomas (Marta Sbaraglia and Angelo P. Dei Tos; ONCOLOGY IMAGING)https://doi.org/10.1007/s11547-018-0882-7

Cortex_Dataset

 		Top
Fusion gene CARS--ALK is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

 		Top
The fusion gene pair CARS--ALK information is not available in ChromothripsisDB database.