BRD4--NUTM1

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

 BRD4 NUTM1

COSMIC

The fusion gene pair BRD4--NUTM1 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair BRD4--NUTM1 information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
BRD4_NUTM1-/2380/ -/172/ Exonic hg19 - - - - Cosmic_recurrent

ChimerPUB

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The fusion gene pair BRD4--NUTM1 information is not available in CHIMERPUB (CHIMERDB 3.0) database.

ChimerSEQ

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The fusion gene pair BRD4--NUTM1 information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
BRD4_NUTM1chr19/15391262/ chr15/34640165/ 19p13.12 15q14 Exonic hg19 - Inter-chr carcinoma AY166680 - ChiTaRs

ChiTaRS 2.1

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The fusion gene pair BRD4--NUTM1 information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human AY166680BRD4--NUTM1 BRD419 15364963 15391262 - 1 2380 100 NUTM115 34640165 34649933 + 2376 6004 100

FARE-CAFE

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The fusion gene pair BRD4--NUTM1 information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
BRD4-NUTM1 highly lethal cancer arises from respiratory mucosa FISH,Southern blotting t(15;19)(q13;p13.1) PubMed:11733348

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
BRD4-NUTM1 BRD4-NUTM1 BRD4 15366264 1 0 NUTM1 34640165 1 0 GGCCGCGTGGTGCACATCATCCAGTCACGGGAGCCCTCCCTGAAGAATTCCAACCCCGACGAGATTGAAATCGACTTTGAGACCCTGAAGCCGTCCACACTGCGTGAGCTGGAGCGCTATGTCACCTCCTGTTTGCGGAAGAAAAGGAAACCTCAAGCTGAGAAAGTTGATGTGATTGCCGGCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGCATCTGCATTGCCGGGACCGGATATGAGCATGAAACCTAGTGCCGCCCTGTCTCCATCCCCTGCACTTCCCTTTCTCCCACCAACTTCTGACCCACCAGACCACCCACCCAGGGAGCCACCTCCACAGCCCATCATGCCTTCAGTATTCTCTCCAGACAACCCTCTGATGCTCTCTGCTTTCCCCAGCTCACTGTTGGTGACAGGGGACGGGGGCCCTTGCCTCAGTGGGGCTGGGGCTGGCAAGGTCATTGTCAAAGTCAAGACAGAAGGGGGGTCAGCTGAGCCCTCTCA 11733348 _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
BRD4-NUTM1 BRD4-NUTM1 - - 1) NUT_N
2) NUT_C
-BRD4 1) Bromodomain
2) BET
3) BRD4_CDT
1) PHD , Bromodomain , ASF1_hist_chap , DUP902
NUTM1 1) NUT_N
2) NUT_C
- 1) Bromodomain
2) BET
3) BRD4_CDT
1) PHD , Bromodomain , ASF1_hist_chap , DUP902

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
BRD4-NUTM1 hsa-miR-335-5p, hsa-miR-423-5p hsa-miR-26b-5p, hsa-miR-2110, hsa-miR-877-3p, hsa-miR-455-3p, hsa-miR-484, hsa-miR-320a Microarray,NGS

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
BRD4-NUTM1 NM_014299.2 1) MITF_HUMAN
2) STAT1_HUMAN
3) RB1_HUMAN
4) RBL2_HUMAN
5) RUNX1_HUMAN
6) ETS1_HUMAN
7) EGR1_HUMAN
8) GATA3_HUMAN
9) E2F1_HUMAN
10) CTCF_HUMAN
11) BRG1_HUMAN
12) HNF4A_HUMAN
13) TFAP2C_HUMAN
14) FOXA1_HUMAN
15) CEBPA_HUMAN
16) NR1H3_HUMAN
17) TRIM24_HUMAN
18) VDR_HUMAN
- 1) 21258399
2) 19122651
3) 20385362
4) 20385362
5) 20019798
6) 20019798
7) 20690147
8) 21878914
9) 21310950
10) 21795385
11) 19505939
12) 21646355
13) 21572391
14) 21572391
15) 20219941
16) 22292898
17) 21164480
18) 21846776

TicDB

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The fusion gene pair BRD4--NUTM1 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair BRD4--NUTM1 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair BRD4--NUTM1 information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair BRD4--NUTM1 information is not available in ConjoinG Database.

1000Genome

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Fusion gene BRD4--NUTM1 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene BRD4--NUTM1 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene BRD4--NUTM1 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene BRD4--NUTM1 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene BRD4--NUTM1 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair BRD4--NUTM1 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene BRD4--NUTM1 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene BRD4--NUTM1 has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene BRD4 is a known oncogene according to ONGENE database.


The tail gene NUTM1 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene BRD4 is cancer associated according to Bushman Cancer Gene database.


The tail gene NUTM1 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene BRD4 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene NUTM1 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene BRD4--NUTM1 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene BRD4--NUTM1 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair BRD4--NUTM1 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene BRD4--NUTM1 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene BRD4--NUTM1 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair BRD4--NUTM1 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair BRD4--NUTM1 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair BRD4--NUTM1 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene BRD4--NUTM1 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair BRD4--NUTM1 information is not available in ChromothripsisDB database.