| ATIC_ALK | inv(2)(p23q35) / t(2;5)(p23;q35) / t(1;2)(q25;p23) / t(2;5) / |
10702393 | non Hodgkin Lymphoma |
FISH |
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ATIC-ALK: A novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35).. /// ATIC-ALK fusion resulting from the inv(2)(p23q35) thus provides a third mechanism of ALK activation in ALK+ ALCL.. /// The ATIC-ALK fusion was confirmed in Case 1 and also identified in Case 2 by conventional reverse transcriptase-polymerase chain reaction using ATIC forward and ALK reverse primers.
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| ATIC_ALK | t(2;5)(p23;q35) / inv(2)(p23q35) / t(2;17)(p23;q25) / |
11395396 | anaplastic large cell lymphoma;lymphoma |
FISH;PCR;RT-PCR |
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The NPM-ALK and the ATIC-ALK fusion genes can be detected in non-neoplastic cells.. /// "The aims of the present study were to investigate the presence of NPM-ALK and ATIC-ALK fusion genes in ALCL, using a real-time 5' exonuclease-based reverse-transcription polymerase chain reaction (RT-PCR). " /// "The aims of the present study were to investigate the presence of NPM-ALK and ATIC-ALK fusion genes in ALCL, using a real-time 5' exonuclease-based reverse-transcription polymerase chain reaction (RT-PCR)." /// "Other rearrangements involving the ALK gene have recently been shown to be associated with ALCL, among which the ATIC-ALK rearrangement resulting from the inv(2)(p23q35) translocation is probably the most recurrent. " /// "Our findings demonstrate that NPM-ALK and ATIC-ALK fusion transcripts may be detected in conditions other than ALK-positive ALCL including reactive lymphoid tissues, although at low levels, suggesting the presence of the transcripts in normal (bystander) cells. " /// "Similarly, out of the three strongly positive ATIC-ALK cases, one case was positive for the NPM-ALK fusion, at low levels. " /// "Finally, the NPM-ALK and the ATIC-ALK fusions were detected, at equally low levels, respectively in 13 and 5 ALK-negative ALCL cases, in 11 and 5 Hodgkin's disease cases and in 20 and 1 non-neoplastic lymphoid tissues. " /// RT-PCR detected the NPM-ALK and ATIC-ALK fusions at high levels in 8 and 3 of a total of 13 ALK-positive ALCL cases. /// "In addition, of the eight ALK-positive ALCL cases that were strongly positive for the NPM-ALK fusion, three cases also showed the presence of the ATIC-ALK fusion, although at much lower levels. "
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| ATIC_ALK | t(2;5)(p23;q35) / t(2;5) / t(2;5) / t(2;19)(p23;p13) / inv(2) / |
15080301 | anaplastic large cell lymphoma;lymphoma |
FISH |
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Among 6 variant gene rearrangements, 1 had TPM4-ALK/t(2;19)(p23;p13) and 2 had inv(2) with the breakpoint proximate to ATIC-ALK and an unknown partner gene separately.
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| ATIC_ALK | - |
14631806 | anaplastic large cell lymphoma;anaplastic large cell lymphoma;lymphoma |
FISH;PCR |
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The morphological investigations are supplemented by karyotyping and/or by a demonstration of breakpoint at 2p23 harboring ALK gene (FISH), and by molecular detection of chimeric genes characteristic of ALK+ lymphomas (NPM-ALK, ATIC-ALK, TPM3-ALK, TFG-ALK, and some even rarer rearrangements). /// "The morphological investigations are supplemented by karyotyping and/or by a demonstration of breakpoint at 2p23 harboring ALK gene (FISH), and by molecular detection of chimeric genes characteristic of ALK+ lymphomas (NPM-ALK, ATIC-ALK, TPM3-ALK, TFG-ALK, and some even rarer rearrangements). "
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| ATIC_ALK | - |
25501114 | acute myeloid leukemia;anaplastic large cell lymphoma;myeloid leukemia;leukemia;lymphoma |
FISH;PCR |
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We subsequently confirmed ATIC-ALK and TRAF1-ALK fusions by reverse transcriptase PCR and nucleotide sequencing. /// We subsequently confirmed ATIC-ALK and TRAF1-ALK fusions by reverse transcriptase PCR and nucleotide sequencing.
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| ATIC_ALK | t(2;5)(p23;q35) / t(1;2)(q25;p23) / t(2;3)(p23;q21) / t(2;17)(p23;q23) / inv(2)(p23q35) / |
15208656 | anaplastic large cell lymphoma;lymphoma |
- |
- |
Recent studies demonstrated that ALK may also be involved in variant translocations, namely, t(1;2)(q25;p23), t(2;3)(p23;q21), t(2;17)(p23;q23) and inv(2)(p23q35), which create the TPM3-ALK, TFG-ALK5, CLTC-ALK, and ATIC-ALK fusion genes, respectively. /// "We stably transfected the cDNAs coding for NPM-ALK, TPM3-ALK, TFG-ALK, CLTC-ALK or ATIC-ALK into nonmalignant NIH3T3 cells. "
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| ATIC_ALK | t(2;5)(p23;q35) / t(2;17)(p23;q25) / t(2;11;2)(p23;p15;q31) / |
12112524 | anaplastic large cell lymphoma;lymphoma |
- |
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While most of the ALK-positive ALCL (ALKomas) are characterized by the presence of the NPM-ALK fusion protein, the product of the t(2;5)(p23;q35), 10-20% of ALKomas contain variant ALK fusions, including ATIC-ALK, TFG-ALK, CLTC-ALK (previously designated CLTCL-ALK), TMP3-ALK, and MSN-ALK.
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| ATIC_ALK | p23;q35 / t(2;5) / |
10994999 | anaplastic large cell lymphoma;non Hodgkin lymphoma;B cell lymphoma;lymphoma |
PCR;RT-PCR |
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in some instances, the breakpoints have been cloned and the genes forming a new fusion gene with ALK have been identified: ATIC-ALK, TFG-ALK and TPM3-ALK.
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| ATIC_ALK | - |
12939746 | - |
FISH;PCR;RT-PCR |
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Subsequent FISH and RT-PCR analysis confirmed the ALK-ATIC chimeric fusion in tumor cells. /// ALK-ATIC fusion in urinary bladder inflammatory myofibroblastic tumor..
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| ATIC_ALK | t(2;5)(p23;q35) / / |
10706887 | non Hodgkin lymphoma;anaplastic large cell lymphoma;lymphoma |
PCR;RT-PCR |
- |
Our studies demonstrate an alternative mechanism for ALK involvement in the genesis of NHL and suggest that ATIC-ALK activation results from ATIC-mediated homodimerization.
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| ATIC_ALK | - |
17464320 | anaplastic large cell lymphoma;lymphoma |
PCR;RT-PCR |
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The 5' RACE assay detected ATIC-ALK fusion in the remaining case.
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| ATIC_ALK | - |
10706082 | anaplastic large cell lymphoma;lymphoma |
- |
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Expression of full-length ATIC-ALK cDNA in mouse fibroblasts revealed that the fusion protein (a) possesses constitutive tyrosine kinase activity; (b) forms stable complexes with the signaling proteins Grb2 and Shc; (c) induces tyrosine-phosphorylation of Shc; and (d) provokes oncogenic transformation. /// Nucleotide sequence analysis of ALK transcripts isolated by 5'-rapid amplification of cDNA ends revealed a chimeric mRNA corresponding to an ATIC-ALK in-frame fusion.
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| ATIC_ALK | - |
18572809 | anaplastic large cell lymphoma;lymphoma |
- |
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ATIC-ALK chimeric transcripts were detected by reverse transcriptase polymerase chain reaction.
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