ALK--EML4

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

 ALK EML4

COSMIC

The fusion gene pair ALK--EML4 information is not available in COSMIC database.

ChimerKB

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The fusion gene pair ALK--EML4 information is not available in CHIMERKB (CHIMERDB 3.0) database.

ChimerPUB

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The fusion gene pair ALK--EML4 information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
ALK_EML4- 26988569non small cell lung cancer;lung cancer FISH - Currently, several approaches are being used to detect echinoderm microtubule associated protein like 4 gene (EML4)-anaplastic lymphoma receptor tyrosine kinase gene (ALK) rearrangement, but the performance of laboratories in China is unknown. /// Reliability Assurance of Detection of EML4-ALK Rearrangement in Non-Small Cell Lung Cancer: The Results of Proficiency Testing in China.. /// "We prepared formalin-fixed, paraffin-embedded samples derived from the xenograft tumor tissue of three non-small cell lung cancer cell lines with different EML4-ALK rearrangements and used PTs to evaluate the detection performance of laboratories in China. " /// Our PT survey revealed that the performance and methodological problems of laboratories must be addressed to further increase the reproducibility and accuracy of detection of EML4-ALK rearrangement to ensure reliable results for selection of appropriate patients.. /// "To evaluate the proficiency of different laboratories in detecting EML4-ALK rearrangement, we organized a proficiency test (PT). "

ChimerSEQ

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The fusion gene pair ALK--EML4 information is not available in CHIMERSEQ (CHIMERDB 3.0) database.

ChiTaRS 2.1

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The fusion gene pair ALK--EML4 information is not available in CHITARS database.

FARE-CAFE

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The fusion gene pair ALK--EML4 information is not available in FARE-CAFE.

TicDB

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The fusion gene pair ALK--EML4 information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair ALK--EML4 information is not available in TUMOR FUSION Gene Data Portal.

FusionCancer

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The fusion gene pair ALK--EML4 information is available in FusionCancer Database.
Database_IDHead_gene_symbolHead_breakpoint_locationTail_gene_symbolTail_breakpoint_locationCancer_typeSRA
FUSC003224ALKchr2:29446394EML4chr2:42522656Lung cancerERR164608
FUSC003224ALKchr2:29446393EML4chr2:42522655Lung cancerERR164608

ConjoinG

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The fusion gene pair ALK--EML4 information is not available in ConjoinG Database.

1000Genome

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Fusion gene ALK--EML4 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene ALK--EML4 is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene ALK--EML4 is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene ALK--EML4 is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene ALK--EML4 was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair ALK--EML4 information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene ALK--EML4 is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene ALK--EML4 has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene ALK is a known oncogene according to ONGENE database.


The tail gene EML4 is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene ALK is cancer associated according to Bushman Cancer Gene database.


The tail gene EML4 is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene ALK is proto-oncogene or tumor suppresor gene according to Uniprot database.
The tail gene EML4 is not a proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene ALK--EML4 is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene ALK--EML4 is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair ALK--EML4 information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene ALK--EML4 is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene ALK--EML4 has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair ALK--EML4 information is not available in Klijn Dataset.

Fimereli_Dataset

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The fusion gene pair ALK--EML4 information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair ALK--EML4 information is not found in known fusion genelist compiled from literature.

Cortex_Dataset

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Fusion gene ALK--EML4 is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair ALK--EML4 information is not available in ChromothripsisDB database.