ABL1--BCR

Hyperlinks to databases below
COSMIC CHIMERKB CHIMERPUB CHIMERSEQ CHITARS
FARE-CAFE TICDB TUMOR_FUSION_GDPFusionCancerConjoinG
1000Genome18CancersBodymap2HPANon_Tumor_Cells
Babiceanu_DatasetBanned_DatasetKnown_FusionsONGene DatabaseBushman Cancer Gene Database
Tumor Gene Set By UniprotOesophagus_DatasetGliomas_DatasetProstate_DatasetPancreases_Dataset
GTExKlijn_DatasetFimereli_Dataset Literature Cortex_Dataset
ChromothripsisDB

Link to Genecards:

ABL1 BCR

COSMIC

The fusion gene pair ABL1--BCR information is not available in COSMIC database.

ChimerKB

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The fusion gene pair ABL1--BCR information is available in CHIMERKB (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)Breakpoint_TypeGenome_BuildDiseaseValidationPMIDGene TypeSource
ABL1_BCR-/-/ -/-/ - hg18 chronic myelogenous leukemia - 6584200 Kinase; Oncogene; OMIM
ABL1_BCR-/-/ -/-/ - hg18 acute lymphocytic leukemia - 3513189 Kinase; Oncogene; OMIM
ABL1_BCR-/-/ -/-/ - hg18 chronic myelogenous leukemia - 7665185 Kinase; Oncogene; OMIM
ABL1_BCR-/-/ -/-/ - hg18 acute lymphocytic leukemia - 7665185 Kinase; Oncogene; OMIM

ChimerPUB

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The fusion gene pair ABL1--BCR information is available in CHIMERPUB (CHIMERDB 3.0) database.

Fusion_pairTranslocationPMIDDiseaseValidationGene TypeSentence_highlight
ABL1_BCR- 17130661chronic myeloid leukemia;myeloid leukemia;leukemia FISH - In addition, some rearrangements are complex, and do not yield the ABL/BCR fusion due to the involvement of a third chromosome in the rearrangement. /// "In the process of generating BCR-ABL fusion, the deletion of residual BCR or ABL occurs in 15-30 percent of CML patients. " /// Patients enrolled in our prospective study of prognostic significance will be followed up for disease free and overall survival in correlation with ABL-BCR deletion status..
ABL1_BCRt(9;22) / 22058195leukemia - - The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia chromosome.
ABL1_BCRt(1;19) / 22023462chronic myeloid leukemia;myeloid leukemia;leukemia - - Unique to this patient was the evidence of both breakpoint cluster region-c-abl oncogene 1 (BCR-ABL1) fusions as well as an additional unbalanced t(1;19) translocation.
ABL1_BCR- 23471097chronic myeloid leukemia;myeloid leukemia;leukemia PCR - Current guidelines for managing Philadelphia-positive chronic myeloid leukemia include monitoring the expression of the BCR-ABL1 (breakpoint cluster region/c-abl oncogene 1, non-receptor tyrosine kinase) fusion gene by quantitative reverse-transcription PCR (RT-qPCR). /// Our goal was to establish and validate reference panels to mitigate the interlaboratory imprecision of quantitative BCR-ABL1 measurements and to facilitate global standardization on the international scale (IS). /// Establishment and validation of analytical reference panels for the standardization of quantitative BCR-ABL1 measurements on the international scale.. /// "For most methods, percent ratios for BCR-ABL1 e13a2 and e14a2 relative to ABL1 or BCR were robust at 4 different levels and linear over 3 logarithms, from 10% to 0.01% on the IS. " /// "The synthetic calibrator panels are robust, reproducibly manufactured, analytically calibrated to the WHO primary standards, and compatible with most BCR-ABL1 RT-qPCR assay designs. " /// "The broad availability of secondary reference reagents will further facilitate interlaboratory comparative studies and independent quality assessment programs, which are of paramount importance for worldwide standardization of BCR-ABL1 monitoring results and the optimization of current and new therapeutic approaches for chronic myeloid leukemia.. "

ChimerSEQ

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The fusion gene pair ABL1--BCR information is available in CHIMERSEQ (CHIMERDB 3.0) database.

Fusion_pair5'Gene Junction (Chr/Position/Strand)3'Gene Junction (Chr/Position/Strand)5'Gene_locus3'Gene_locusBreakpoint_TypeGenome_BuildFrameChr_infoCancertype_or_diseaseBarcodeIDGene TypeSource
ABL1_BCRchr9/133589842/+ chr22/23634727/+ 9q34.12 22q11.23 Exonic hg19 In-Frame Inter-chr LAML TCGA-AB-2901-03A Kinase; Oncogene; FusionScan
ABL1_BCRchr9/133589842/+ chr22/23634727/+ 9q34.12 22q11.23 Exonic hg19 In-Frame Inter-chr LAML TCGA-AB-2941-03A Kinase; Oncogene; FusionScan
ABL1_BCRchr9/133609600/ chr22/23633410/ 9q34.12 22q11.23 Exonic hg19 - Inter-chr NA JQ425243 Kinase; Oncogene; ChiTaRs
ABL1_BCRchr9/133611321/ chr22/23632429/ 9q34.12 22q11.23 Exonic hg19 - Inter-chr NA JQ425252 Kinase; Oncogene; ChiTaRs
ABL1_BCRchr9/133651594/ chr22/23633431/ 9q34.12 22q11.23 Exonic hg19 - Inter-chr NA JQ425250 Kinase; Oncogene; ChiTaRs
ABL1_BCRchr9/133715193/ chr22/23632419/ 9q34.12 22q11.23 Exonic hg19 - Inter-chr NA JQ425248 Kinase; Oncogene; ChiTaRs
ABL1_BCRchr9/133614221/ chr22/23632569/ 9q34.12 22q11.23 Exonic hg19 - Inter-chr NA JQ425245 Kinase; Oncogene; ChiTaRs
ABL1_BCRchr9/133686164/ chr22/23632728/ 9q34.12 22q11.23 Exonic hg19 - Inter-chr NA JQ425240 Kinase; Oncogene; ChiTaRs
ABL1_BCRchr9/133589842/+ chr22/23595986/+ 9q34.12 22q11.23 Exonic hg19 In-frame Inter-chr LAML TCGA-AB-2817-03A Kinase; Oncogene; PRADA
ABL1_BCRchr9/133589842/+ chr22/23634728/+ 9q34.12 22q11.23 Exonic hg19 In-frame Inter-chr LAML TCGA-AB-2901-03A Kinase; Oncogene; PRADA
ABL1_BCRchr9/133589842/+ chr22/23634728/+ 9q34.12 22q11.23 Exonic hg19 In-frame Inter-chr LAML TCGA-AB-2941-03A Kinase; Oncogene; PRADA

ChiTaRS 2.1

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The fusion gene pair ABL1--BCR information is available in CHITARS database.

OrganismChimeraIDFusion genepairHead geneTail gene
GeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%IdentGeneChromosomeGenomic_startGenomic_stopStrandFusiongene_startposFusiongene_endpos%Ident
Human JQ425243ABL1--BCR ABL19 133609456 133609600 + 1 145 100 BCR22 23633410 23633491 + 144 225 100
Human JQ425252ABL1--BCR ABL19 133611244 133611321 + 1 78 100 BCR22 23632429 23632575 + 79 225 100
Human JQ425250ABL1--BCR ABL19 133651520 133651594 + 1 75 100 BCR22 23633431 23633580 + 76 225 100
Human JQ425248ABL1--BCR ABL19 133715072 133715193 + 1 122 99.2 BCR22 23632419 23632522 + 122 225 100
Human JQ425245ABL1--BCR ABL19 133614085 133614221 + 1 137 100 BCR22 23632569 23632656 + 138 225 100
Human JQ425240ABL1--BCR ABL19 133686036 133686164 + 1 129 100 BCR22 23632728 23632823 + 130 225 100

FARE-CAFE

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The fusion gene pair ABL1--BCR information is available in FARE-CAFE.

Cancer Information
Fusion_ProteinCancer_TypeFP_Experimental_MethodFP_KaryotypeFP_Reference
ABL1-BCR Chronic Myeloid Leukemia,Acute Lymphoblastic Leukemia,Acute Myelocytic Leukemia,Chronic Neutrophilic Leukemia,Erythro leukaemia PCR,FISH,Western blot,RT-PCR,Southern blot,DNA sequencing,G-Banding,Cyclesequencing,PFGE t(9;22)(q34;q11) PubMed:17268511

Genomic Information
Fusion_ProteinFusion_Protein_Isoforms5'_ProteinF_B_PFBP_in_Exon/Intron5'_Protein_on_Positive/Negative_Strands3'_ProteinS_B_P3'_Protein_on_Positive/Negative_StrandsSBP_in_Exon/IntronFusion_Protein_mRNA_sequenceFusion_Protein_ReferenceFusion_Protein_GenbankID
ABL1-BCR ABL1-BCR-Isoform1 ABL1 _ _ 1 BCR _ 1 _ _ _ _
ABL1-BCR ABL1-BCR-Isoform2 ABL1 133705847 0 1 BCR 23632592 1 1 _ _ _
ABL1-BCR ABL1-BCR-Isoform3 ABL1 133622350 0 1 BCR 23603225 1 1 _ _ _
ABL1-BCR ABL1-BCR-Isoform4 ABL1 _ _ 1 BCR 23631801 1 1 _ _ _

Domains and DDI Information
Fusion_ProteinFusion_Protein_IsoformsDomains_in_5'PartnerDDIs_for_Domains_in_5'PartnerDomains_in_3'PartnerDDIs_for_Domains_in_3'Partner5'_Protein5'P_Domains5'P_Domains_DDI_partners3'_Protein3'P_Domains3'P_Domains_DDI_partnersMissing_FP_DomainsMissing_FP_Domains_DDI
ABL1-BCR ABL1-BCR-Isoform1 - - - -ABL1 1) SH3_1
2) SH2
3) Pkinase_Tyr
4) F_actin_bind
1) SH3_1 , Ank_2 , P53 , ubiquitin , Asp , PB1 , SH3_2 , F-protein , Pkinase_Tyr , Trypsin , Guanylate_kin , SH2 , p47_phox_C
2) C1_1 , PI3Ka , SH3_1 , Y_phosphatase , C2 , PI3_PI4_kinase , SH3_2 , fn3 , PAG , Pkinase_Tyr , SOCS_box , PI3K_C2 , SH2 , STAT_bind
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
BCR 1) Bcr-Abl_Oligo
2) RhoGEF
3) PH
4) C2
5) RhoGAP
1) Bcr-Abl_Oligo
2) C1_1 , G-alpha , Histone , PH , PH_5 , RGS , Ras , RasGEF_N , RhoGEF , SH3_9
3) Arf , BTK , C1_1 , CAMSAP_CH , Dynamin_M , IRS , PH , Pkinase , RA , Ras , RhoGEF , SH3_9 , Sif , WD40
4) C2 , PI-PLC-X , S_100 , EF-hand_10 , PI-PLC-Y , EF-hand_like , PLA2_B , FGF , SH2
5) Ras , C1_1 , RhoGAP
1) SH3_1
2) SH2
3) Pkinase_Tyr
4) F_actin_bind
5) Bcr-Abl_Oligo
6) RhoGEF
7) PH
8) C2
9) RhoGAP
1) SH3_1 , Ank_2 , P53 , ubiquitin , Asp , PB1 , SH3_2 , F-protein , Pkinase_Tyr , Trypsin , Guanylate_kin , SH2 , p47_phox_C
2) C1_1 , PI3Ka , SH3_1 , Y_phosphatase , C2 , PI3_PI4_kinase , SH3_2 , fn3 , PAG , Pkinase_Tyr , SOCS_box , PI3K_C2 , SH2 , STAT_bind
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
4) Bcr-Abl_Oligo
5) C1_1 , G-alpha , Histone , PH , PH_5 , RGS , Ras , RasGEF_N , RhoGEF , SH3_9
6) Arf , BTK , C1_1 , CAMSAP_CH , Dynamin_M , IRS , PH , Pkinase , RA , Ras , RhoGEF , SH3_9 , Sif , WD40
7) C2 , PI-PLC-X , S_100 , EF-hand_10 , PI-PLC-Y , EF-hand_like , PLA2_B , FGF , SH2
8) Ras , C1_1 , RhoGAP
ABL1-BCR ABL1-BCR-Isoform2 - - 1) RhoGEF
2) PH
1) C1_1 , G-alpha , Histone , PH , PH_5 , RGS , Ras , RasGEF_N , RhoGEF , SH3_9
2) Arf , BTK , C1_1 , CAMSAP_CH , Dynamin_M , IRS , PH , Pkinase , RA , Ras , RhoGEF , SH3_9 , Sif , WD40
ABL1 1) SH3_1
2) SH2
3) Pkinase_Tyr
4) F_actin_bind
1) SH3_1 , Ank_2 , P53 , ubiquitin , Asp , PB1 , SH3_2 , F-protein , Pkinase_Tyr , Trypsin , Guanylate_kin , SH2 , p47_phox_C
2) C1_1 , PI3Ka , SH3_1 , Y_phosphatase , C2 , PI3_PI4_kinase , SH3_2 , fn3 , PAG , Pkinase_Tyr , SOCS_box , PI3K_C2 , SH2 , STAT_bind
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
BCR 1) Bcr-Abl_Oligo
2) RhoGEF
3) PH
4) C2
5) RhoGAP
1) Bcr-Abl_Oligo
2) C1_1 , G-alpha , Histone , PH , PH_5 , RGS , Ras , RasGEF_N , RhoGEF , SH3_9
3) Arf , BTK , C1_1 , CAMSAP_CH , Dynamin_M , IRS , PH , Pkinase , RA , Ras , RhoGEF , SH3_9 , Sif , WD40
4) C2 , PI-PLC-X , S_100 , EF-hand_10 , PI-PLC-Y , EF-hand_like , PLA2_B , FGF , SH2
5) Ras , C1_1 , RhoGAP
1) SH3_1
2) SH2
3) Pkinase_Tyr
4) F_actin_bind
5) Bcr-Abl_Oligo
1) SH3_1 , Ank_2 , P53 , ubiquitin , Asp , PB1 , SH3_2 , F-protein , Pkinase_Tyr , Trypsin , Guanylate_kin , SH2 , p47_phox_C
2) C1_1 , PI3Ka , SH3_1 , Y_phosphatase , C2 , PI3_PI4_kinase , SH3_2 , fn3 , PAG , Pkinase_Tyr , SOCS_box , PI3K_C2 , SH2 , STAT_bind
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
4) Bcr-Abl_Oligo
ABL1-BCR ABL1-BCR-Isoform3 - - 1) RhoGEF
2) PH
3) C2
4) RhoGAP
1) C1_1 , G-alpha , Histone , PH , PH_5 , RGS , Ras , RasGEF_N , RhoGEF , SH3_9
2) Arf , BTK , C1_1 , CAMSAP_CH , Dynamin_M , IRS , PH , Pkinase , RA , Ras , RhoGEF , SH3_9 , Sif , WD40
3) C2 , PI-PLC-X , S_100 , EF-hand_10 , PI-PLC-Y , EF-hand_like , PLA2_B , FGF , SH2
4) Ras , C1_1 , RhoGAP
ABL1 1) SH3_1
2) SH2
3) Pkinase_Tyr
4) F_actin_bind
1) SH3_1 , Ank_2 , P53 , ubiquitin , Asp , PB1 , SH3_2 , F-protein , Pkinase_Tyr , Trypsin , Guanylate_kin , SH2 , p47_phox_C
2) C1_1 , PI3Ka , SH3_1 , Y_phosphatase , C2 , PI3_PI4_kinase , SH3_2 , fn3 , PAG , Pkinase_Tyr , SOCS_box , PI3K_C2 , SH2 , STAT_bind
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
BCR 1) Bcr-Abl_Oligo
2) RhoGEF
3) PH
4) C2
5) RhoGAP
1) Bcr-Abl_Oligo
2) C1_1 , G-alpha , Histone , PH , PH_5 , RGS , Ras , RasGEF_N , RhoGEF , SH3_9
3) Arf , BTK , C1_1 , CAMSAP_CH , Dynamin_M , IRS , PH , Pkinase , RA , Ras , RhoGEF , SH3_9 , Sif , WD40
4) C2 , PI-PLC-X , S_100 , EF-hand_10 , PI-PLC-Y , EF-hand_like , PLA2_B , FGF , SH2
5) Ras , C1_1 , RhoGAP
1) SH3_1
2) SH2
3) Pkinase_Tyr
4) F_actin_bind
5) Bcr-Abl_Oligo
1) SH3_1 , Ank_2 , P53 , ubiquitin , Asp , PB1 , SH3_2 , F-protein , Pkinase_Tyr , Trypsin , Guanylate_kin , SH2 , p47_phox_C
2) C1_1 , PI3Ka , SH3_1 , Y_phosphatase , C2 , PI3_PI4_kinase , SH3_2 , fn3 , PAG , Pkinase_Tyr , SOCS_box , PI3K_C2 , SH2 , STAT_bind
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
4) Bcr-Abl_Oligo
ABL1-BCR ABL1-BCR-Isoform4 - - 1) Bcr-Abl_Oligo
2) RhoGEF
3) PH
1) Bcr-Abl_Oligo
2) C1_1 , G-alpha , Histone , PH , PH_5 , RGS , Ras , RasGEF_N , RhoGEF , SH3_9
3) Arf , BTK , C1_1 , CAMSAP_CH , Dynamin_M , IRS , PH , Pkinase , RA , Ras , RhoGEF , SH3_9 , Sif , WD40
ABL1 1) SH3_1
2) SH2
3) Pkinase_Tyr
4) F_actin_bind
1) SH3_1 , Ank_2 , P53 , ubiquitin , Asp , PB1 , SH3_2 , F-protein , Pkinase_Tyr , Trypsin , Guanylate_kin , SH2 , p47_phox_C
2) C1_1 , PI3Ka , SH3_1 , Y_phosphatase , C2 , PI3_PI4_kinase , SH3_2 , fn3 , PAG , Pkinase_Tyr , SOCS_box , PI3K_C2 , SH2 , STAT_bind
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2
BCR 1) Bcr-Abl_Oligo
2) RhoGEF
3) PH
4) C2
5) RhoGAP
1) Bcr-Abl_Oligo
2) C1_1 , G-alpha , Histone , PH , PH_5 , RGS , Ras , RasGEF_N , RhoGEF , SH3_9
3) Arf , BTK , C1_1 , CAMSAP_CH , Dynamin_M , IRS , PH , Pkinase , RA , Ras , RhoGEF , SH3_9 , Sif , WD40
4) C2 , PI-PLC-X , S_100 , EF-hand_10 , PI-PLC-Y , EF-hand_like , PLA2_B , FGF , SH2
5) Ras , C1_1 , RhoGAP
1) SH3_1
2) SH2
3) Pkinase_Tyr
4) F_actin_bind
1) SH3_1 , Ank_2 , P53 , ubiquitin , Asp , PB1 , SH3_2 , F-protein , Pkinase_Tyr , Trypsin , Guanylate_kin , SH2 , p47_phox_C
2) C1_1 , PI3Ka , SH3_1 , Y_phosphatase , C2 , PI3_PI4_kinase , SH3_2 , fn3 , PAG , Pkinase_Tyr , SOCS_box , PI3K_C2 , SH2 , STAT_bind
3) Inhibitor_Mig-6 , Y_phosphatase , Pkinase_Tyr , SH3_9 , EphA2_TM , CH , SH3_1 , Pkinase , BPS , AvrPto , FERM_M , SH2

miRNA Information
Fusion_ProteinmiRNAs_Targets_Fusion_proteinMissing_MiRNAs_Targets_Fusion_proteinFP_miRNA_Validation_method
ABL1-BCR hsa-miR-744-5phsa-miR-10a-5phsa-miR-197-3p hsa-miR-203ahsa-miR-29a-3phsa-miR-30a-5phsa-miR-484hsa-miR-342-3phsa-miR-149-5phsa-miR-125b-5phsa-let-7b-5p NGS

Transcription Factors Information
Fusion_Protein5'P_Ref_mRNA_seqIDFP_Transcription_factorsFP_Missing_TFsFP_TF_Reference
ABL1-BCR NM_005157.4 1) MITF_HUMAN
2) RB1_HUMAN
3) STAT1_HUMAN
4) RBL2_HUMAN
5) ZNF263_HUMAN
6) E2F4_HUMAN
7) P53_HUMAN
8) RUNX1_HUMAN
9) ETS1_HUMAN
10) EGR1_HUMAN
11) FOS_HUMAN
12) GATA2_HUMAN
13) GATA3_HUMAN
14) E2F1_HUMAN
15) SOX2_HUMAN
16) CTCF_HUMAN
17) BRG1_HUMAN
18) HNF4A_HUMAN
19) TFAP2C_HUMAN
20) CEBPA_HUMAN
21) ESR1_HUMAN
22) SETDB1_HUMAN
23) TRIM24_HUMAN
24) VDR_HUMAN
1) ESTROGEN RECEPTOR ALPHA_HUMAN
2) TAL1_HUMAN
3) FOXA1_HUMAN
4) STAT6_HUMAN
5) ESR2_HUMAN
6) MEIS1_HUMAN
7) FOXP1_HUMAN
8) NR1H3_HUMAN
9) SPI1_HUMAN
1) 21258399
2) 20385362
3) 19122651
4) 20385362
5) 19887448
6) 21247883
7) 21394211
8) 20019798
9) 20019798
10) 20690147
11) 20139302
12) 21808000
13) 21878914
14) 21310950
15) 21211035
16) 21795385
17) 19505939
18) 21646355
19) 21572391
20) 20219941
21) 21566084
22) 21430779
23) 21164480
24) 21846776

TicDB

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The fusion gene pair ABL1--BCR information is not available in TicDB.

TUMOR FUSION Gene Data Portal

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The fusion gene pair ABL1--BCR information is available in TUMOR FUSION Gene Data Portal.
CancerTCGA_barcodeFusionPairEvalue5'Gene_Junction3'Gene_JunctionTierFrameTNWGS_validation
LAML AB-2817-03A ABL1__BCR 0.035 9:133589842/1 22:23595986/1 tier1 In-frame 105 NA
LAML AB-2901-03A ABL1__BCR 0.035 9:133589842/1 22:23634728/1 tier1 In-frame 106 NA
LAML AB-2941-03A ABL1__BCR 0.035 9:133589842/1 22:23634728/1 tier1 In-frame 107 NA

FusionCancer

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The fusion gene pair ABL1--BCR information is not available in FusionCancer Database.

ConjoinG

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The fusion gene pair ABL1--BCR information is not available in ConjoinG Database.

1000Genome

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Fusion gene ABL1--BCR has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

18Cancers

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Fusion gene ABL1--BCR is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016 )

Bodymap2

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Fusion gene ABL1--BCR is not found in the list of known false positive fusion genes. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

HPA

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Fusion gene ABL1--BCR is not found in a healthy sample (RNA-seq database of 27 healthy tissues from 95 human individuals). A candidate fusion gene found in this dataset has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Non_Tumor_Cells

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Fusion gene ABL1--BCR was not found among the fusion genes which have been previously reported/found in non-tumor cell lines, like for example HEK293. The genes which are observed in those list can be considered as non-somatic mutation. [Fusion gene List compiled from FusionCatcher]

Babiceanu_Dataset

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The fusion gene pair ABL1--BCR information is not available in Babiceanu_Dataset.

Banned_Dataset

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Fusion gene ABL1--BCR is not found in the list of known false positive fusion genes. A candidate fusion gene found in this list has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Known_Fusions

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Fusion gene ABL1--BCR has been found in the list of fusions previously reported or published in scientific articles/reports/books/abstracts/databases, indexed by Google, Google Scholar, PubMed, etc. This label has only the role to answer with YES or NO the question "has ever before a given (candidate) fusion gene been published or reported?". This label does not have in anyway the role to provide the original references to the original scientific articles/reports/books/abstracts/databases for a given fusion gene.[Fusion gene List compiled from FusionCatcher]

ONGene Database

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The head gene ABL1 is a known oncogene according to ONGENE database.


The tail gene BCR is a known oncogene according to ONGENE database.

Bushman Cancer Gene Database

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The head gene ABL1 is cancer associated according to Bushman Cancer Gene database.


The tail gene BCR is cancer associated according to Bushman Cancer Gene database.

Tumor Gene Set By Uniprot

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The head gene ABL1 is proto-oncogene or tumor suppresor gene according to Uniprot database.


The tail gene BCR is proto-oncogene or tumor suppresor gene according to Uniprot database.

Oesophagus_Dataset

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Fusion gene ABL1--BCR is not found in oesophageal tumors from TCGA samples, which are published here.

Gliomas_Dataset

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Fusion gene ABL1--BCR is not found in the RNA-seq dataset of 272 glioblastomas, published here.

Prostate_Dataset

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The fusion gene pair ABL1--BCR information is not available in Prostate Dataset (150 prostate tumor RNAs, Robison et al, Integrative Clinical Genomics of Advanced Prostate Cancer, Cell, Vol. 161, May 2015, http://dx.doi.org/10.1016/j.cell.2015.05.001).

Pancreases_Dataset

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Fusion gene ABL1--BCR is not found in pancreatic tumor dataset, published here.

GTEx

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Fusion gene ABL1--BCR has not been found in a healthy sample (GTEx database of healthy tissues (thru FusionAnnotator)). A candidate fusion gene found in this set has a very high probability of being a false positive. [Fusion gene List compiled from FusionCatcher]

Klijin_Dataset

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The fusion gene pair ABL1--BCR information is available in Klijn Dataset.

Cell lineGene 5'Gene 3'Read evidenceKinaseChromosome 5'Position 5'Chromosome 3'Position 3'Fusion type DNAFusion type RNAFusion protein lengthTissueKnown Fusion
KU812ABL1BCR36Y91335898422223634728TranslocinFrame389Lymphoid5-prime known
SUP-B15ABL1BCR9Y91335898422223595986TranslocinFrame890Lymphoid5-prime known
HNT-34ABL1BCR31Y91335898422223634728TranslocinFrame389Lymphoid5-prime known

Fimereli_Dataset

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The fusion gene pair ABL1--BCR information is not found in Fimereli_Dataset.

Literature

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The fusion gene pair ABL1--BCR is found in known fusion genelist compiled from literature.

FusionGeneArticleLink
ABL1--BCRDevelopment and Verification of an RNA Sequencing (RNA-Seq) Assay for the Detection of Gene Fusions in Tumorshttps://doi.org/10.1016/j.jmoldx.2018.03.007

Cortex_Dataset

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Fusion gene ABL1--BCR is not found in Cortex_Dataset (Fusion genes found in healthy human brains (BA9 prefrontal cortex)) . A candidate fusion gene found in this dataset has a very high probability of being a false positive.

ChromothripsisDB

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The fusion gene pair ABL1--BCR information is not available in ChromothripsisDB database.