Domain View (BED format as Input)
Visualization is an important aspect of data interpretation. In FusionHub server, we provide three different ways of fusion gene visualization: Circular view, Domain architecture view and Fusion gene network view.
Fusion translocation breakpoints in cancer are known to be non-random and mostly biased towards preservation of reading frame and functional viability of fusion protein. Studying different ways by which head/tail genes fused together and maintain domain integrity is useful to understand the driving force behind gene fusion events.
The domain architecture view will display graphically all known fusion breakpoint locations, exonic structures of wild type head/tail gene and fusion genes, the protein domains which are part of fusion genes. We use AGFusion for this.
It takes fusion information as 4 column bed format with information such as Head gene, Tail gene, Head gene breakpoint, Tail gene breakpoint. Chromosome information are automatically fetched from human genome annotation file (hg38/hg19).
HeadGene TailGene 5'Junction 3'Junction
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