Circos View
Gene pair as Input

Domain View
Gene pair as Input
BED format as Input

Network View
Gene as Input
GenePair as Input

Domain View (Gene pair as Input)

Visualization is an important aspect of data interpretation. In FusionHub server, we provide three different ways of fusion gene visualization: Circular view, Domain architecture view and Fusion gene network view.

Fusion translocation breakpoints in cancer are known to be non-random and mostly biased towards preservation of reading frame and functional viability of fusion protein. Studying different ways by which head/tail genes fused together and maintain domain integrity is useful to understand the driving force behind gene fusion events.

The domain architecture view will display graphically all known fusion breakpoint locations, exonic structures of wild type head/tail gene and fusion genes, the protein domains which are part of fusion genes. We use AGFusion for this.

It takes fusion gene pairs as input, in the format of Headgene--Tailgene. User can input one or more fusion gene pairs, one pair per line, allowing for batch visualization.

Domain View

No domain image

Input Example

No domain image

Search by Fusion gene pair

Enter fusion gene pair (Each pair in one line)    

Example   Clear

Note: At present we rely on ChimerSeq database to fetch breakpoint information. If the given fusion is not found in ChimerSeq database, no domain image can be shown. In that case, you can use the second mode of running the job where you provide the breakpoint location manually in BED format.